Stablix- Senior Scientist, Medicinal Chemistry

Found in: Appcast Linkedin GBL C2 - 2 weeks ago

Boston, United States Stablix, Inc. Full time

Stablix- Senior Scientist, Medicinal Chemistry


The company

Stablix is a venture-backed preclinical stage drug discovery company, pioneering an entirely new field of targeted deubiquitination therapeutics to bring transformative medicines to patients with high unmet medical need. Our platform generates novel bifunctional molecules that selectively recruit deubiquitinases (DUBs) to target proteins to precisely remove ubiquitin for therapeutic advantage. We are a creative and multidisciplinary team of scientists, innovators and leaders dedicated to changing the drug discovery and development paradigm. Stablix has labs and offices in Boston MA and NYC, NY.


The position

Stablix offers the opportunity to work at a big concept biotechnology company. We are seeking motivated, collaborative, and experienced individuals to join the medicinal chemistry team. Equipped with a broad background in synthetic organic chemistry, the successful candidate will have a strong knowledge of hit-to-lead optimization to clinical candidate, and the ability to be dynamic working across multiple projects. This position will be in person in our Boston office.


Duties/Responsibilities:

Contribute to medicinal chemistry strategy that aligned with project goals

Analyze structure-activity relationships to design compounds for lead optimization of biological activity, molecular properties and pharmacokinetic parameters

Work in close collaboration with internal and external chemistry teams to efficiently progress compound optimization and scale up campaign

Collaborate with colleagues across multiple disciplines to rapidly progress leads towards clinical candidates

Communicate medicinal chemistry strategy, objectives, progress & challenges to key stakeholders



Qualifications / Education / Experience


Advanced degree in synthetic/organic/medicinal chemistry

3 to 5+ years of experience in drug discovery and development in a biotech or pharmaceutical setting

Experience working with heterobifunctional molecules desirable

Highly creative and productive with excellent knowledge of synthetic chemistry methodologies

Strong medicinal chemistry and drug design knowledge with a solid understanding of ADME/PK, biology, and pharmacology principles

Experience working with external CRO chemistry teams

Experience being the chemistry lead on multidisciplinary project teams, driving compound progression through hit optimization to development candidates.

Highly collaborative team player with effective communication skills

Proven record of working efficiently in a fast-paced environment with a strong sense of urgency

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