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Senior Research Associate, Process Development

3 months ago

Cambridge, United States Thymmune Therapeutics Full time
Job DescriptionJob Description

About Us

Thymmune Therapeutics is a preclinical biotechnology company based in Cambridge, MA applying proprietary insights in thymic engineering to develop and commercialize immune cell therapy products addressing significant opportunities with unmet clinical need across immunology. Building on work from leading labs, Thymmune has strong IP positioning and is backed by early investors and founders of successful high-profile biotechnology companies.

Role Description

Our innovation and value-driven organization seeks to hire a Senior Research Associate with industry experience to join our rapidly growing Process Development team. The role will assist in developing and transferring robust and scalable processes for cell therapy projects, as well as supporting the efficient operation of the laboratory and the performance of scientific studies. The candidate should have extensive knowledge of aseptic cell culture techniques, stem cell differentiation, and statistical data analysis.  Experience with multicolor flow cytometry and/or real-time PCR is required. Experience with design-of-experiment (DOE), result-database development, and JMP statistical data analysis is preferred.

Key Responsibilities

  • Maintain stem cell, stem cell-derived, and primary tissue cultures in a variety of experimental conditions.
  • Support execution of process development experiments to develop processes for iPSC expansion, differentiation, formulation, fill-finish, and cryopreservation.
  • Independently conduct molecular biology procedures, such as FACS, biomarker screening, real-time PCR, and immunocytochemistry.

·       Participate in the design and modification and troubleshooting of development protocols.

  • Develop and maintain experimental result databases.
  • Conduct data analysis using appropriate statistical tests.
  • Prepare and contribute to technical reports, SOPs, batch records, internal presentations, and technology transfer initiatives.
  • Maintain and order tissue culture, molecular biology, and equipment supplies.
  • Coordinate laboratory compliance and procedures in the areas of safety, environmental, and infection control.
  • Supervise the orientation and training of new laboratory staff and interns.

Required Qualifications and Skills

  • Bachelor’s degree with 2+ years of experience or Master’s degree with 1+ years of experience, ideally in fields such as pluripotent stem cell-based regenerative medicine, bioengineering, or a related discipline.
  • Basic knowledge of process development and cGMP principles. Prior hands-on experience with cell therapy process equipment is preferred.
  • Experience with design-of-experiments (DOE), result-database management, and JMP statistical data analysis is preferred.
  • Experience with PCR and flow cytometry is required.
  • Proficiency in aseptic tissue culture techniques is required.
  • High degree of computer literacy, analytical, and organizational skills.
  • Excellent oral and written communication skills.
  • Knowledge of ELN maintenance.
  • Must be able to structure tasks and set priorities logically and effectively.
  • Highly motivated and able to perform experiments independently.
  • Ability to identify potential problems and troubleshoot solutions.
  • Must have a broad knowledge of scientific principles, biological structures, and laboratory techniques.
  • Must have sound interpersonal skills and the ability to collaborate with other team members and senior management.
  • Occasional weekend work is required.

 

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