Scientist/Senior Scientist Immunology

3 weeks ago

Boston, United States Hillstar Bio Full time
Job DescriptionJob Description

About the Company

Hillstar Bio, is a precision immunology company that recently completed a sizable Series A financing with a syndicate of blue-chip investors (Droia, Frazier, Novo, LifeArc).

Hillstar aspires to build a portfolio of programs against autoimmune diseases with unmet or underserved medical needs. Its lead program is an antibody designed to selectively target a root cause of Cold Agglutinin Disease (CAD) and Systemic Lupus Erythematosus (SLE). CAD is a chronic, rare (incidence 15/million) but debilitating condition with high morbidity (anemia, fatigue, cold-induced circulatory symptoms). SLE on the other hand, affects an estimated 3 million adults worldwide, with symptoms affecting various organs including joints, kidneys, blood cells, brain, heart, and lungs. Existing treatment options for CAD and SLE have limited effectiveness, carry considerable safety risks, and fail to address key disease symptoms in a large proportion of patients, leading to significant chronic morbidity and excess mortality. By bringing this new precision modality to patients, Hillstar aims to improve on safety and efficacy, as well as durability of response, setting a new gold standard for the management of CAD, SLE, and potentially other serious autoimmune conditions with a common biological origin.

Job Description

Join Hillstar Bio as a Scientist/Senior Scientist Immunology overseeing the design and execution of in vitro and in vivo mechanistic, proof-of-concept and safety studies, provide scientific and technical expertise in immune cell biology, and support regulatory filing with authoring of technical reports.

This pivotal role offers a chance to shape our company culture, make a meaningful impact on patient care, and contribute to the growth of a pioneering organization. We seek a passionate, hands-on scientist with a collaborative spirit, ready to thrive in a dynamic, close-knit team environment.

Requirements

Essential Duties and Responsibilities

  • Design, execute, and analyze in vitro and in vivo experiments to investigate disease-causing mechanisms and generate proof-of-concept studies.
  • Create and execute in vitro and in vivo models of autoimmune diseases.
  • Develop and perform biochemical and biological assay (ELISA, flow cytometry, immunofluorescence)
  • Provide scientific guidance to external academic collaborations, vendors, CROs.
  • Assist in authoring technical reports for regulatory filing.
  • Catalyze emerging scientific breakthroughs in precision immunology into new discovery programs.
  • Play a key team role in building and fostering Hillstar’s culture and contribute to its growth.
  • Collaborate on various aspects of general business and people operations, as needed.

Qualifications

  • PhD in Immunology or related field.
  • A minimum of 5 years of experience in drug development in biotech or pharma setting, with a focus on autoimmune diseases.
  • Demonstrated experience in humoral and cell-mediated immunology, experience with B-cell depleting therapies is highly preferred.
  • Demonstrated experience with biochemical and cell-based assays (flow cytometry and microscopy is required).
  • Relevant experience is reflected by a track record of patents and high impact publications.
  • Self-motivated, collaborative, excellent time management and interpersonal skills.
  • Experience with antibody development is a plus.

Benefits

Compensation and Benefits

Hillstar Bio offers a competitive compensation and benefits package that includes unlimited vacation and market-leading parental leave.

Additional Information

This is a full-time position located in our Boston, MA office. Hillstar is committed to creating a diverse work culture and we are seeking individuals of all backgrounds, orientations, and identities. We are an equal opportunity employer and do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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