Scientist, Downstream Process Development
4 weeks ago
We are seeking an Associate Scientist to join our Downstream Process Development Department – Process Sciences in Gaithersburg, MD. This a six month contract position. Qualified individuals will play role in downstream process development; scale up, and technical support of cGMP manufacturing for protein-based vaccines. The candidate will ensure scientifically sound design and scalable purification processes are created. The candidate will also be responsible for generating materials for developmental studies. The candidate is expected to be highly self-motivated, well organized, and very productive.
Responsibilities include but are not limited to:
- Support the development of purification process by reviewing and compiling relevant literature data
- Perform scale-up of processes to deliver materials for pre-clinical and clinical studies
- Execute optimization experiments to demonstrate that the process is robust with high purity, yield, and scalable for clinical stage manufacturing of vaccine and other biologic product candidates
- Design experimental work with supervision of senior scientists
- Ability to process complex data and clearly communicate the implications of the results
- Generate, manage, evaluate, and maintain critical data in a highly organized manner and provide assessment reports
- Provide reagents and other supplies for various projects and departments
- Support process characterization studies, process validation and tech transfer process as needed
- Maintaining inventory of lab supplies and ordering lab consumables as needed
- Responsible for preparation of buffers and column packing at different scales
- Performs testing of in-process samples such as SDS-PAGE, Western blot, A280 (Nanodrop), BCA, DNA, and host cell protein ELISA assays
- Operates the glass washing instruments and autoclaves as needed
- This position is expected to be hands on in the laboratory and scale-up operation
Minimum requirements:
- MS in relevant scientific discipline with 0-2 years of directly relevant experience
- BS in relevant scientific discipline with 4-5+ years of directly relevant experience
- Hands-on Downstream purification experience is required
Preferred qualifications:
- Knowledge in purification of vaccines/biologics; Experience in various chromatography methods, filtration, and TFF unit operations at bench scale and/or pilot scale is a plus
- Capable of performing multiple functions in a fast-paced environment. Strong technical protocol/report writing, and good organization skills are required
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