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Upstream Process Development scientist

2 months ago

Germantown, United States uBriGene Biosciences Full time
Job DescriptionJob Description

Summary:

We are looking for an experienced RA/Scientist whose work will focus on upstream process development at our Process Development Department. The incumbent is expected to possess comprehensive, hands-on experiences with cell culture, small scale bioreactors and fermenters. Experience with molecular and cellular analysis is also highly desired.

RESPONSIBILITIES:

  • Design and execution upstream experiments across various volumes
  • Identify and optimize process parameters to support and control the growth of a mammalian or microbial cell line in a production bioreactor
  • Develop and evaluate novel media compositions, supplementation, and feeding strategies to optimize our development process
  • Maintain bench-scale bioreactors and prepare media, buffers, and chemical solutions
  • Product sampling and chemical/microbiological analysis
  • Bioreactor and laboratory material cleaning and sterilization
  • Analyze, interpret, and present results to project teams, and write technical reports.
  • Help and participate in manufacturing processes
  • Support the scale-up of upstream/downstream processes and technology transfer to the cGMP manufacturing and quality control (QC) groups for clinical material production/analysis.
  • Maintain domain expertise in new technologies and scientific literature.
QUALIFICATIONS:
  • B.S. with 3+ years, M.S. with 1+ years of relevant experience in industry, or PhD in Chemical Engineering/Biological engineering/Cell Biology/Biochemistry/Biology or related scientific subject areas with 0-2 years of proven experience.
  • Experience with aspects of process development such as scale up, upstream and downstream processes.
  • Ability to design, organize and execute complex experiments
  • Ability to work independently while being a team player
  • Able to prepare and make comprehensive presentations
  • Exposure to industrial cell culture process development
  • Hands on experience with small-scale bioreactor set-up and operations, along with flasks.
  • Proficient laboratory skills, including quantitative sample transfer, consistent and reproducible media preparation and familiarity with measurement of pH and conductivity.
  • Experience with writing technical documents such as tech transfer documents, SOPs, and progress reports.

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