Scientist, Mass Spectrometry
2 weeks ago
Parvus Therapeutics Inc. is a privately held biopharmaceutical company developing Navacims™, a platform technology based on foundational research published in 2016 (Nature 530:434), to treat autoimmune diseases. Parvus’ mission is to shift the treatment paradigm toward Navacim™-directed immune regulation, avoiding non-specific immune suppression associated with current therapies. Parvus’ innovative approach has the potential to benefit millions of patients suffering from debilitating autoimmune diseases and other chronic inflammatory conditions. Parvus is advancing a pipeline of proprietary drug candidates for multiple autoimmune indications through preclinical development and into the clinic. Parvus’ leadership team is experienced in successful drug discovery, development, manufacturing, regulatory approval, and commercialization.
About Navacims™
Navacims™ are a novel first-in-class nanomedicine designed to treat autoimmune disease by selectively modulating disease-specific cellular responses without impairing normal immunity. Navacims™ specifically target and act only on disease causing effector T cells, delivering a signal that programs effector T cells to differentiate into regulatory T (Treg) cells specific for self-antigens relevant to the patient’s disease. These disease- or tissue-specific Treg cells induce immunological tolerance to block undesired immune responses to self-antigens, while maintaining normal immune surveillance and activity.
The Position
We are seeking a Scientist to join the Protein Sciences and Process Development Group. The ideal candidate will conduct protein characterization mass spectrometry activities to support our pre-clinical and clinical programs with the Parvus technology platform. The individual should have extensive experience with protein characterization mass spectrometry, preferably peptide mapping, glycan analysis, glycobiology, and related protein post-translational modifications. Experience with in-vitro ELISA or activity assays is a plus.
Primary Responsibilities:
- Primary contributor with protein characterizing mass spectrometry experiments, including maintaining the instrument, developing and performing experiments with an emphasis on intact mass, glycan analysis and peptide mapping studies.
- Learn, develop, and perform in vitro protein and nanoparticle biophysical and binding characterization assays.
- Prepare technical documents for transfer to contract manufacturers.
- Work collaboratively in multi-functional groups to test drug substance critical quality attributes.
- Contribute scientifically to the growing knowledge base of the Parvus technology platform.
- Develop and execute detailed SOP’s that can be readily transferred to outside partners and document experiments in a lab notebook.
- Present at team meetings, across Parvus, and with our business partners as needed to drive studies and provide analytical support to material production and manufacturing.
- Ph.D. in biochemistry, chemistry, or a related discipline
- 0-1 year of hands-on experience in industry. Experience with mass spectrometry, with an emphasis on glycan analysis and post-translational modification characterizations.
- Expertise setting up, maintaining, and running LC/MS equipment independently or with minimal assistance is required.
- Expert at solving technical challenges in protein characterization and assay development.
- Experience with ELISAs is a plus.
- Analytical problem solving and organizational skills are required to identify and resolve technical challenges.
- Ability to work independently in the laboratory and in cross-functional teams.
- Comfortable working collaboratively in a small, fast-paced environment.
- Ability to quickly adjust to shifting project demands and priorities.
- Good oral, written communication, and presentation skills.
Powered by JazzHR
Y8BuCaahfP
-
South San Francisco, United States The Fountain Group LLC Full timePay Range: $61-$101/hour Job Description: 12-month contract with the possibility of converting to permanent based on company needs and worker's performance. The Translational Medicine department informs clinical development of Client personalized therapeutics through establishment of biomarker strategies aimed to study biological pathways driving...
-
Senior/Principal Scientist in Translational Medicine Mass Spectrometry
Found in: Talent US C2 - 2 weeks ago
South San Francisco, United States Compass Consulting Full timeOur client is a leading biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. Job Overview: Our client's Translational...
-
South San Francisco, United States Planet Pharma Full timeThe Translational Medicine department informs clinical development of novel personalized therapeutics through establishment of biomarker strategies aimed to study biological pathways driving disease and by characterizing the mechanism of action of novel therapeutics. As a key member of the biomarker mass spectrometry laboratory, the ideal candidate will...
-
Senior/Principal Scientist in Translational Medicine Mass Spectrometry
Found in: Appcast Linkedin GBL C2 - 2 weeks ago
South San Francisco, United States Compass Consulting Full timeOur client is a leading biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multiple products on the market and a promising development pipeline. Job Overview:Our client's Translational...
-
South San Francisco, United States HonorVet Technologies Full timeThe Translational Medicine department at Genentech informs clinical development of Client personalized therapeutics through establishment of biomarker strategies aimed to study biological pathways driving disease and by characterizing the mechanism of action of Client therapeutics. As a key member of the biomarker mass spectrometry laboratory, the ideal...
-
South San Francisco, United States Compass Consulting Group Full timeOur client is a leading biotechnology company that discovers, develops, manufactures, and commercializes medicines to treat patients with serious or life-threatening medical conditions. They are among the world's leading biotech companies, with multi Spectrometry, Medicine, Scientist, Principal, Technology, Staffing
-
Senior/Principal Scientist
2 days ago
San Francisco, United States R&D Partners Full timeR&D Partners is seeking to hire a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Contractor) in San Franciscon, CA. Your main responsibilities as a Senior/ Principal Scientist in Translational Medicine Mass Spectrometry (Con Scientist, Principal, Clinical Research, Spectrometry, Chemistry, Staffing
-
Senior Principal Scientist
2 weeks ago
South San Francisco, United States Magnit Full timeTitle: Senior/Principal Scientist in Translational Medicine Mass SpectrometryLocation: South San Francisco, CA - ONSITEDuration: 12+ Months contract role Job description:Description:The Translational Medicine department at Genentech informs clinical development of novel personalized therapeutics through establishment of biomarker strategies aimed to study...
-
Senior Principal Scientist
Found in: Appcast US C2 - 2 weeks ago
South San Francisco, United States Magnit Full timeTitle: Senior/Principal Scientist in Translational Medicine Mass SpectrometryLocation: South San Francisco, CA - ONSITEDuration: 12+ Months contract role Job description:Description:The Translational Medicine department at Genentech informs clinical development of novel personalized therapeutics through establishment of biomarker strategies aimed to study...
-
Senior Principal Scientist
Found in: Appcast Linkedin GBL C2 - 2 weeks ago
South San Francisco, United States Magnit Full timeTitle: Senior/Principal Scientist in Translational Medicine Mass SpectrometryLocation: South San Francisco, CA - ONSITEDuration: 12+ Months contract role Job description:Description:The Translational Medicine department at Genentech informs clinical development of novel personalized therapeutics through establishment of biomarker strategies aimed to study...
-
Associate Scientist II
Found in: beBee jobs US - 2 weeks ago
South San Francisco, California, United States Collabera Full timeOperate and maintain analytical and preparative scale HPLC instrumentation.Purification of samples from medicinal chemistry projects on a milligram to gram scale by preparative HPLC.Maintain and troubleshoot NMR spectrometer under the guidance of senior scientists.Hands-on experience with analytical HPLC, preparative HPLC, mass spectrometry, and/or...
-
Data Scientist
Found in: beBee jobs US - 3 weeks ago
San Francisco, California, United States Calico Full timePosition Description:Calico is seeking an expert data scientist or computational biologist to join our multidisciplinary team of mass spectrometrists, biologists and computer scientists to become an integral part of our solution for proteomics.At Calico we are generating large quantities of proteomics data both from large, unique cohort studies as well as...
-
Research Associate
2 days ago
South San Francisco, United States Aequor Technologies LLC Full timeJob Title: Research Associate Location: South San Francisco, CA Duration: 1 year contract Note: The hiring manager's target would be for someone in level I-II, but they could stretch to level III depending on their experience and skill set. This is considered a high-risk position. Responsibilities: We are seeking a talented and motivated individual keen...
-
Research Associate
Found in: Talent US C2 - 2 weeks ago
South San Francisco, United States Innova Solutions Full timeInnova Solutions is immediately hiring for a Research AssociatePosition type: Full time ContractDuration: 12 months Location: South San Francisco, CAAs a Research Associate, you will: Job Description:Responsibilities:We are seeking a talented and motivated individual keen on utilizing structural mass spectrometry, specifically hydrogen-deuterium exchange (HX...
-
Associate Scientist II
2 weeks ago
South San Francisco, United States Collabera Full timeJob DescriptionJob DescriptionOperate and maintain analytical and preparative scale HPLC instrumentation.Support and troubleshoot walk-up analytical LC-MS instrumentation.Purification of samples from medicinal chemistry projects on a milligram to gram scale by preparative HPLC.Maintain and troubleshoot NMR spectrometer under the guidance of senior...
-
Postdoctoral Fellow, In Vivo Metabolism
2 days ago
San Francisco, United States California Life Company Full timePosition description: Calico is seeking a Postdoctoral Fellow who is excited to be part of a scientific team dedicated to unraveling the fundamentals of the aging process. We are looking for a scientist with a strong background in cellular and in vivo metabolism interested in applying this training to advance our understanding of the molecular mechanisms by...
-
Bioinformatics Data Scientist
7 days ago
San Mateo, United States Theery Full timeDescription of roleThis is a hybrid work position with expectations of being onsite several times a week.Duties:Analyze molecular assay data spanning genomics to proteomics to uncover disease-specific signals from liquid biopsies.Develop molecular assay data processing pipelines.Evaluate, research and develop analysis methods for molecular assay data and...
-
Bioinformatics Data Scientist
Found in: Appcast Linkedin GBL C2 - 7 days ago
San Mateo, United States Theery Full timeDescription of roleThis is a hybrid work position with expectations of being onsite several times a week.Duties:Analyze molecular assay data spanning genomics to proteomics to uncover disease-specific signals from liquid biopsies.Develop molecular assay data processing pipelines.Evaluate, research and develop analysis methods for molecular assay data and...
-
Bioinformatics Data Scientist
Found in: Appcast US C2 - 7 days ago
San Mateo, United States Theery Full timeDescription of roleThis is a hybrid work position with expectations of being onsite several times a week.Duties:Analyze molecular assay data spanning genomics to proteomics to uncover disease-specific signals from liquid biopsies.Develop molecular assay data processing pipelines.Evaluate, research and develop analysis methods for molecular assay data and...
-
Staff Research Associate II
Found in: beBee S US - 2 weeks ago
San Francisco, United States University of California - San Francisco Full timeThe BCMM is focused on human microbiome research, with a particular interest in accelerating discovery and translation in the fields of early life microbiome and therapeutic development.The Center supports multiple collaborative technology hubs that facilitate microbiome research projects led by researchers across UCSF.Metabolomics: Sample preparation for...