Research Scientist I

4 weeks ago

Watertown, United States C4 Therapeutics Inc Full time
Job DescriptionJob Description

Our Opportunity:

C4 Therapeutics is seeking an enthusiastic, scientifically-motivated Research Scientist to join our Biology team. The candidate will play a significant role in the design and execution of in vitro and in vivo studies to characterize and differentiate the biological consequences of our small molecule therapeutics to advance drug discovery programs. The ideal candidate will possess a background in cancer biology and experience in a drug discovery setting. In addition, the successful candidate will have a strong commitment to team success, an ability to work effectively as part of a team, and the ability to work on multiple projects simultaneously. This position seeks individuals who are comfortable in a fast-paced environment and are interested in and committed to laboratory-based research and innovation. This position will provide many opportunities for high impact work and the chance to influence the direction of a project in a data-driven manner. C4 Therapeutics is committed to investing in all our employees by providing strong and compassionate leadership, defined career growth opportunities, exposure to state-of-the-art techniques, generous employee benefits packages, and a positive and supportive workplace environment filled with highly talented and collaborative colleagues.

Key Responsibilities:

  • Design and execute cell-based studies to support identification, validation, and differentiation of small molecule protein degraders, implementing a wide variety of laboratory techniques including mammalian cell culture, Western blotting, CRISPR, RNAi, phenotypic assays, flow cytometry, etc.
  • Act as the Biology Lead in efforts to advance drug discovery projects in a multidisciplinary, collaborative project team setting: perform cell-based studies and design and manage the execution of in vivo studies at CROs to achieve project goals, interpret and communicate results, and recommend next steps to the project teams.
  • Build a deep understanding of our targets as they progress through the phases of drug discovery towards the clinic.
  • Manage CROs for outsourced work, including in vitro and in vivo studies (no vivarium on site).
  • Understand and integrate the current literature surrounding TPD and specific targets of interest
  • Maintain written records of laboratory experiments, data, conclusions, and communicate results in a clear/concise manner.
  • Contribute to collaborative problem solving with cross functional teamwork.

Your Background:

  • Ph.D. in Biology or other relevant discipline, M.S. with 2+ years of experience working in an industry setting, or BS with 5+ years of experience working in an industry setting.
  • Strong record of success in critical thinking and scientific creativity demonstrated by publications and/or drug discovery experience.
  • Demonstrated hands-on experience in independent experimental design, execution, data analysis and troubleshooting.
  • Background in cancer biology is preferred.
  • Demonstrated proficiency with mammalian cell culture techniques is preferred.
  • Self-motivated, willingness to learn, strong work ethic, attention to detail, organizational skills, and excellent communication skills.
  • Proficiency in utilizing software such as Microsoft Office, GraphPad Prism, etc.
  • Works well in a collaborative team-oriented environment and is capable of multi-tasking in an exciting, fast-paced environment.

C4 Therapeutics is an Equal Opportunity Employer.

  • Scientific Programmer

    6 days ago

    Watertown, United States Convergent Research Full time

    Parallel Squared Technology Institute (PTI) is a non-profit research institute aiming to catalyze a leap in protein analysis technology and use it to explore new biological frontiers. PTI supports open research and educational opportunities supporting rapid career development for scientists, engineers, and mathematicians. Why? Protein dysfunctions directly...

  • Application Scientist

    4 days ago

    Watertown, United States SYNCELL INC. Full time

    Job Summary: As an application scientist you will be at the forefront of applying cutting-edge microscopy technologies for human disease research, drug discovery assays, and disease relevant biomarker study. You will be collaborating with customers to carry out exciting cell and tissue proteomics studies. This position is an onsite position that is based in...

  • Application Scientist

    4 days ago

    Watertown, United States SYNCELL INC. Full time

    Job Summary: As an application scientist you will be at the forefront of applying cutting-edge microscopy technologies for human disease research, drug discovery assays, and disease relevant biomarker study. You will be collaborating with customers to carry out exciting cell and tissue proteomics studies. This position is an onsite position that is based in...

  • RA/Associate Scientist

    1 day ago

    Watertown, United States ClinLab Staffing Full time

    Research Associate/Associate scientist, Oligonucleotides About the jobA new, ambitious, stealth biotech company has been launched and successfully funded by one of the top venture firms in the industry. This Boston-based company has a new delivery platform technology for novel, targeted and ground-breaking therapeutics for various indications.Job...

  • RA/Associate Scientist

    1 day ago

    Watertown, United States ClinLab Staffing Full time

    Research Associate/Associate scientist, Oligonucleotides About the jobA new, ambitious, stealth biotech company has been launched and successfully funded by one of the top venture firms in the industry. This Boston-based company has a new delivery platform technology for novel, targeted and ground-breaking therapeutics for various indications.Job...

  • RA/Associate Scientist

    20 hours ago

    Watertown, United States ClinLab Staffing Full time

    Research Associate/Associate scientist, Oligonucleotides About the jobA new, ambitious, stealth biotech company has been launched and successfully funded by one of the top venture firms in the industry. This Boston-based company has a new delivery platform technology for novel, targeted and ground-breaking therapeutics for various indications.Job...

  • Senior Scientist, Product Sciences

    4 weeks ago

    Watertown, United States Affini-T Full time

    Job DescriptionJob DescriptionAbout Affini-T TherapeuticsAffini-T Therapeutics is an emerging biotechnology company focused on targeting oncogenic driver mutations with a “best-in-class” TCR therapy platform. Our innovative method of discovering high affinity TCRs specific to oncogenic driver mutations is used to develop therapies against malignant...

  • Scientist (Bioanalysis)

    1 week ago

    Watertown, United States TotalMed, Inc. Full time

    Job Title: Bioanalysis Scientist Industry/Sector: Biopharmaceutical ManufacturingLocation: Watertown, MA 02472Schedule: Monday-Friday 8:00am – 5:00pm; 4-5 days On-Site per weekPay: $55-$60/hr + Benefits: Med/Den/Vis, 401kJob Description: Report directly to the Associate Director, Bioanalysis This individual will be part of research focused on discovering...

  • Field Application Scientist

    2 weeks ago

    Watertown, United States SYNCELL INC. Full time

    Job Summary: As a Field Application Scientist specializing in Advanced Microscopy Applications for Cell and Tissue Biology, you will be at the forefront of translating cutting-edge microscopy technologies into impactful solutions for researchers in life sciences. Your role involves providing technical expertise, conducting in-depth training sessions, and...

  • Field Application Scientist

    4 weeks ago

    Watertown, United States SYNCELL INC. Full time

    Job Summary: As a Field Application Scientist specializing in Advanced Microscopy Applications for Cell and Tissue Biology, you will be at the forefront of translating cutting-edge microscopy technologies into impactful solutions for researchers in life sciences. Your role involves providing technical expertise, conducting in-depth training sessions, and...

  • Field Application Scientist

    1 month ago

    Watertown, United States SYNCELL INC. Full time

    Job Summary: As a Field Application Scientist specializing in Advanced Microscopy Applications for Cell and Tissue Biology, you will be at the forefront of translating cutting-edge microscopy technologies into impactful solutions for researchers in life sciences. Your role involves providing technical expertise, conducting in-depth training sessions, and...

  • Clinical Research Coordinator

    4 weeks ago

    Watertown, United States Adams Clinical Full time

    Job DescriptionJob DescriptionAbout Adams Clinical and the Clinical Research Coordinator Position:Adams Clinical, a research site specializing in late-phase psychiatric and neurological drug testing, is seeking entry level applicants for a clinical research coordinator (CRC) position. Adams Clinical has locations in Watertown, MA and Boston, MA and provides...

  • Bioanalytical Scientist

    1 week ago

    Watertown, United States Talent Groups Full time

    Position Summary:The individual will be part of Research focused on discovering novel treatments for ocular and neurologic diseases by targeting the complement cascade. The primary responsibility of this lab-based position is to support the bioanalytical throughput and execution of in vitro and ex vivo pharmacokinetic and pharmacology oligonucleotide...

  • Bioanalytical Scientist

    7 days ago

    Watertown, United States Talent Groups Full time

    Position Summary:The individual will be part of Research focused on discovering novel treatments for ocular and neurologic diseases by targeting the complement cascade. The primary responsibility of this lab-based position is to support the bioanalytical throughput and execution of in vitro and ex vivo pharmacokinetic and pharmacology oligonucleotide...

  • Senior Research Associate, LNP Formulations

    2 weeks ago

    Watertown, United States Tome Biosciences Full time

    At Tome, we are developing the next generation of programmable genomic integration technology. Our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are building an exceptional team and a work environment that is diverse, innovative, rewarding, and fun. We have an opportunity to re-write the patient story,...

  • Associate Director, Drug Product, Process Development

    2 weeks ago

    Watertown, United States Tome Biosciences Full time

    At Tome, we are developing the next generation of programmable genomic integration technology. Our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are building an exceptional team and a work environment that is diverse, innovative, rewarding, and fun. We have an opportunity to re-write the patient story,...

  • Associate Director, Bioinformatics

    4 weeks ago

    Watertown, United States Remix Therapeutics Full time

    Remix launched with a vision to transform patient's lives through modulation of RNA processing. Our breakthrough science provides a path to identify small molecules that impact the expression of disease driving mRNAs and proteins. We take on the challenge of addressing drug targets in diseases of high unmet medical need to bring new therapeutic options to...

  • Associate Director Machine Learning Platform

    3 weeks ago

    Watertown, United States Boston Dynamics Full time

    As Associate Director ML Platform on the Central Software team, you'll spearhead development and expansion of machine learning (ML) capabilities at Boston Dynamics. You'll oversee the design, implementation, and operations of infrastructure, and pipelines that unify how our many product ML/RL engineers and researchers get stuff done. If you are passionate...

  • Quality Control Analyst I/II

    20 hours ago

    Watertown, United States Mariana Oncology Full time

    Job DescriptionJob DescriptionSalary: Reporting:Associate Director, Quality Control Description:Mariana Oncology is focused on an extremely exciting field of oncology of precision radiopharmaceuticals to treat unmet need in solid tumors.  We are at the vanguard in developing best-in-class alpha- and beta-emitting radioligands that target cancer, while...

  • AI Financial Analyst

    7 days ago

    Watertown, United States SS&C Technologies Full time

    SS&C is a global provider of investment and financial services and software for the financial services and healthcare industries. Named to Fortune 1000 list as top U.S. company based on revenue, SS&C is headquartered in Windsor, Connecticut and has 20,000+ employees in over 90 offices in 35 countries. Some 18,000 financial services and healthcare...