Scientist - cell line generation, assay and technology development
2 months ago
Immediate opportunity for a Scientist to support cell line generation, assay and technology development for therapeutic drug targets. This role is working with a growing team at one of the world's leading biotechnnology companies located in Thousand Oaks, CA. Interested in learning more? Apply today
Schedule/Shift: 1st shift, Mon.-Fri.
Position Type: Contract position for 1 year (through August 2025), extension possible.
Essential Duties and Responsibilities:
- The development and optimization of novel cell-based assays ensure successful implementation and routine execution of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets.
- Design and implement laboratory experiments, generate & interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents
- Design, implement, and optimize gene-editing workflows in a manner that enables development and evaluation of cell-based functional assays supporting therapeutic target screening or lead optimization studies.
- Investigate, identify, develop, and optimize new methods/techniques to generate reliable and reproducible data promptly.
- Semi-independently plan and implement experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem resolution skills.
- Maintain proficiency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in group discussions.
- Adherence to good laboratory conduct, documentation practices, and safety guideline
Qualifications:
- PhD or MS with 0-2 years' relevant experience
- Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays (e.g., TR-FRET, BRET, AlphaLISA, HCS, luminescence and fluorescence-based reporter and/or label-free assays)
- Track record of developing, implementing, and performing novel cell-based screening assays in microtiter plates to support early drug discovery research
- Ability to design and implement gene editing (CRISPR knock out/in) workflows enabling the development of targets specific and disease-relevant cell-based assays
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