Scientist/Senior Scientist Histology and Imaging

2 weeks ago

Cambridge, United States Editas Medicine Full time
Job DescriptionJob Description

At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing.

We believe our people are at the core of everything we do, and we’re committed to cultivating a culture where every individual feels valued and included. To do this, we strive to integrate belonging, inclusivity, diversity, and equity into every aspect of our organization.

Together, we are leading the way towards a healthier and more equitable future.

Position Summary

Editas Medicine is seeking a highly motivated, energetic and collaborative scientist to join our DMPK, Nonclinical Safety and Translational Sciences team (DSTS). In this highly technical role, the successful individual will apply histology and imaging knowledge to support both preclinical and clinical programs at Editas. This individual will be responsible for contributing to our scientific strategy, designing preclinical studies, establishing new capabilities in-house as well as working with contract research organizations (CROs) when appropriate to support our gene editing programs. The ideal candidate will have strong technical skills, a broad understanding of drug discovery and development, strong foundational knowledge and ability to work collaboratively with key partners in a matrix team structure. In addition, the candidate should possess qualities such as creative and independent thinking, a positive and team-centered attitude, and an ability to thrive in a fast-paced environment. Prior experience with lipid nanoparticle based (LNP) delivery systems and nucleic acid therapeutics is a plus. The individual in this role will have the opportunity to interact with the discovery/platform team as well as the clinical team, to bring life changing therapies to patients with genetic disorders.

Key Responsibilities:

  • As the Scientist/Senior Scientist Histology and Imaging, you will be responsible for:
  • Independently design, execute, and analyze histopathological experiments (i.e. H&E, IHC, IF, multiplex staining, ISH and other tissue section-based assays) manually and/or with automation.
  • Advise and assist with tissue collection and preparation methods to support the planned analyses.
  • Develop, trouble shoot and optimize assays, and bring new technologies in-house to support various projects.
  • Collaborate as part of a cross-functional team on multiple parallel projects to develop tissue-based assays to support target identification, mechanisms of action, pharmacodynamic and efficacy readouts, toxicity, and biomarker development.
  • Collect imaging datasets using automated whole slide scanners and/or confocal or fluorescence microscopy. Manage instruments and data management systems.
  • Perform imaging analysis using slide scanner software, HALO, or other quantitative image analysis software.
  • Interpret results, write up reports, and present data within the organization and at conferences.
  • Responsible for CRO management for activities aligned with the Imaging work.
  • Maintain records including electronic lab notebook.

Requirements

Required Qualifications:

The ideal candidate will possess:

  • PhD with 2+ years Or Master’s with 5+ years of relevant experience, preferably in an industry setting
  • Prior experience in setting up histology lab.
  • Core expertise in histology, the development and validation of histology-based assays and techniques including H&E, IHC, IF, multiplex staining and ISH.
  • Must have experience with major tissues from rodent and non-rodent species.
  • Must have experience with automatic staining machines and scanners, imaging systems, and image analysis software.
  • Experience with gene editing or gene delivery technologies and lipid nanoparticle delivery is highly desired.
  • Outstanding communication skills, both written and oral, and an ability to work in a team-oriented, multidisciplinary environment.
  • Desirable personal attributes including strong organization skills and attention to detail.
  • Experience mentoring research associates.
  • Proven track record of collaborating with cross-functional teams to meet shared objectives.

Benefits

Benefits Summary:

Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings Account, Dental and Vision Insurance, Life and Disability Insurance, Dependent Care Account, Tuition Reimbursement, 401(k) plan with company match, Employee Stock Purchase Plan, Employee Assistance Plan, Wellness Programs, and a flexible Paid Time Off policy.

If you are a results-focused and collaborative professional with a passion for advancing transformative therapies, we invite you to apply. Join us at the forefront of genetic innovation and be a key contributor to Editas Medicine's mission of redefining healthcare through cutting-edge genetic technologies.

Fostering Belonging. Fueling Innovation. Transforming Lives.

  • Scientist/Senior Scientist Histology and Imaging

    2 weeks ago

    Cambridge, United States Editas Medicine, Inc. Full time

    At Editas, we're driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at...

  • Scientist/Senior Scientist Histology and Imaging

    4 weeks ago

    Cambridge, Massachusetts, United States Editas Medicine Full time

    At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at...

  • Senior Scientist, Technical Development

    3 weeks ago

    Cambridge, Massachusetts, United States Biogen Full time

    Job Description About This Role Biogen is searching for a biophysicist to fill a Senior Scientist position within the Analytical Development (AD) – Biologics/Advanced Therapies & Medicinal Products (ATMP) department in Cambridge, MA. This key technical leadership role will lead the biophysical and higher-order-structure characterization for biologics...

  • Research Scientist

    2 weeks ago

    Cambridge, United States Massachusetts Institute of Technology Full time

    Information on MITs COVID-19 vaccination requirement can be found at the bottom of this posting. RESEARCH SCIENTIST, Brain and Cognitive Sciences / Quest for Intelligence/ Computer Science and Artificial Intelligence Lab--Probabilistic Computing Pro Research Scientist, Research, Software Engineer, Scientist, Computer Science, Technology, Education, Program

  • Scientist or Senior Scientist, Pluripotent Stem Cells

    17 hours ago

    Cambridge, United States Garuda Therapeutics Full time

    Garuda Therapeutics is pioneering the development of off-the-shelf hematopoietic stem cell (HSC)-based cellular therapies for treating patients with blood, bone marrow, immune, and metabolic disorders. The company uses state-of-the-art technologies in developmental biology, gene-editing, stem cells, and mechanobiology to engineer safe, compatible HSCs in...

  • Scientist or Senior Scientist, Pluripotent Stem Cells

    22 hours ago

    Cambridge, United States Garuda Therapeutics Full time

    Garuda Therapeutics is pioneering the development of off-the-shelf hematopoietic stem cell (HSC)-based cellular therapies for treating patients with blood, bone marrow, immune, and metabolic disorders. The company uses state-of-the-art technologies in developmental biology, gene-editing, stem cells, and mechanobiology to engineer safe, compatible HSCs in...

  • Clinical Scientist III

    1 month ago

    Cambridge, United States Randstad Life Sciences US Full time

    This position is anticipated to open within the next couple of months** We are seeking a PhD, PharmD, or MD Clinical Scientist for our Global Pharmaceutical Client in Cambridge, MA. Very attractive pay rate!This role will support a director in the medical scientific contribution to the clinical study (protocol development, validation of study data, review of...

  • Clinical Scientist III

    4 weeks ago

    Cambridge, United States Randstad Life Sciences US Full time

    This position is anticipated to open within the next couple of months** We are seeking a PhD, PharmD, or MD Clinical Scientist for our Global Pharmaceutical Client in Cambridge, MA. Very attractive pay rate!This role will support a director in the medical scientific contribution to the clinical study (protocol development, validation of study data, review of...

  • Clinical Scientist III

    4 weeks ago

    Cambridge, United States Randstad Life Sciences US Full time

    This position is anticipated to open within the next couple of months** We are seeking a PhD, PharmD, or MD Clinical Scientist for our Global Pharmaceutical Client in Cambridge, MA. Very attractive pay rate!This role will support a director in the medical scientific contribution to the clinical study (protocol development, validation of study data, review of...

  • Principal Scientist

    1 month ago

    Cambridge, Massachusetts, United States Nuvalent Inc Full time

    We are seeking an entrepreneurial Medicinal Chemist with strong technical and problem-solving skills in organic and medicinal chemistry.The scientist in this position will work with the Nuvalent team, including the scientific founder, and will be responsible for leading medicinal chemistry efforts on at least one early-stage project operating under a...

  • Sr. Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States MOMA Therapeutics Full time

    MOMA Therapeutics is looking for an experienced Sr. Scientist/Principal Scientist, Computational ChemistryUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity, and collaboration; and...

  • Sr. Scientist

    4 weeks ago

    Cambridge, Massachusetts, United States Momatx Full time

    Sr. Scientist/Principal Scientist, Computational ChemistryUnlocking a new target class in drug discovery is no small task: it requires computation to transform data into insights; it requires scientific and technological excellence; it demands a culture of focus, resilience, creativity, and collaboration; and it requires youis looking to expand our expertise...

  • Research Scientist, Part-Time

    2 weeks ago

    Cambridge, United States Massachusetts Institute of Technology Full time

    RESEARCH SCIENTIST 3, Computer Science and Artificial Intelligence Laboratory (CSAIL) (part-time, 30%), to work with Dr. Neil Thompson as part of the Future. Tech research project. Will be responsible for working collaboratively on projects that unco Research Scientist, Research, Part-Time, Computer Science, Computer Scientist, Scientist, Technology,...

  • Scientist, In Vivo Biology

    4 weeks ago

    Cambridge, United States GC Therapeutics Full time

    Company Overview GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer in synthetic biology,...

  • Scientist, In Vivo Biology

    4 weeks ago

    Cambridge, United States GC Therapeutics Full time

    Company Overview GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent stem cell differentiation technology platform TFome™ was developed in Professor George Church’s lab, a pioneer in synthetic biology,...

  • Research Scientist, Analytical

    2 weeks ago

    Cambridge, United States Waters Corporation Full time

    Come and join our diverse research team in the heart of Cambridge and help us in this new era of innovation! Participate in collaborations across departments, sites and more broadly with the scientific and technical community world-wide. Waters Globa Research Scientist, Analytical, Research, Technical Support, Scientist, Chemistry, Manufacturing, Technology

  • Senior Associate Scientist, Translational In Vivo Sciences

    4 weeks ago

    Cambridge, Massachusetts, United States Biogen Full time

    Job Description About This Role Translational In Vivo Sciences (TIVS) at Biogen is seeking a Senior Associate Scientist to join a cross-functional research effort to enhance the delivery of Biogen’s therapeutics to the central nervous system (CNS) and muscle. These efforts will be applied across multiple therapeutic areas in the neurological and...

  • Scientist/Sr. Scientist, Potency Analytical Development

    1 week ago

    Cambridge, Massachusetts, United States Beam Therapeutics Full time

    Position OverviewWe are seeking a motivated Scientist/Sr. Scientist to join our Analytical Research and Development team and perform method development and qualification for lot release and characterization of cell and gene therapy products and critical materials. S/he will work with a Beam's Analytical Development team to enable the rapid advancement of...

  • Clinical Investigator/Research Scientist

    1 week ago

    Cambridge, United States Massachusetts Institute of Technology Full time

    CLINICAL INVESTIGATOR/ RESEARCH SCIENTIST, Koch Institute for Integrative Cancer Research, to join the Charles W. (1955) and Jennifer C. Johnson Clinical Investigator program. This unique program is designed to create the next generation of physician Research Scientist, Clinical, Investigator, Research, Scientist, Technology, Education, IT

  • Senior Principal Cyber/EW Research Scientist

    1 week ago

    Cambridge, United States Raytheon Technologies Corporation Full time

    Date Posted:2024-04-03 Country:United States of America. Location:MA 105: BBN Headquarters 10 Moulton Street , Cambridge, MA, 02138 USA - Position Role Type:Onsite. At Raytheon, the foundation of everything we do is rooted in our values and a highe Research Scientist, Research, Business Development, Principal, Scientist, Cybersecurity, Manufacturing,...