Senior Research Associate, Preclinical Pharmacology

1 week ago

Boston, United States Verve Therapeutics, Inc. Full time
Job DescriptionJob DescriptionThe Company

Verve is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company's initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2023, Verve was named a Top Place to Work by The Boston Globe for the third consecutive year. Verve is headquartered in Boston, Massachusetts.

The Position

Verve is seeking an in vivo Senior Research Associate to join its growing preclinical pharmacology team. This individual will be focused on developing molecular therapies to address genetic risk factors for cardiovascular disease. The senior research associate will be required to plan and perform in vivo studies to advance Verve's preclinical research.

Job Responsibilities
  • Execute in vivo studies in rodents such as dose administration, blood collection, anesthesia, dissection and tissue collection
  • Develop and run quantitative or semi-quantitative assays to analyze collected samples using molecular biology techniques such as NGS, dPCR or ELISA
  • Compile, graph and statistically analyze data from in vivo studies in mice and rats using graphing software
  • Record all observations in a highly organized manner following good documentation practices within an electronic lab notebook
  • Identify and optimize techniques to evaluate novel LNPs and gene editors in rodent models
  • Troubleshoot scientific and technical challenges and contribute to their resolution
  • Present data and research findings in internal company meetings
  • Support crossfunctional collaboration relationships and projects through in vivo studies
  • Other duties as assigned
Qualifications
  • Bachelor's degree in biology, molecular biology or a similar scientific discipline
  • 3+ years of hands-on in vivo experience using rodent models in a research setting demonstrating proficiency in pharmacology or toxicology studies involving rats, including intravenous and oral dosing, collecting blood samples for hematology assessments, processing blood into serum or plasma, necropsies with blood and tissue collection
  • Prior experience analyzing large data sets with GraphPad Prism, Sigmaplot
  • Prior experience with Microsoft office
  • Experience designing, conducting, and analyzing data from in vivo pharmacology studies
  • Surgical experience in rodent models is a plus
  • Experience with high-throughput genomic DNA extraction and next generation sequencing preferred
  • Excellent verbal and written communication skills and the ability to work effectively across functions

Don't check off every box in the requirements listed above? Please consider applying anyway. We want the best candidates for the job, and those candidates don't always meet 100% of the qualifications listed. At Verve, we are dedicated to building diverse and inclusive teams who embody the values we share: grit, spirit, drive, and passion. We look forward to learning more about your unique background.

EEO Statement

Verve Therapeutics is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. If you have a disability or special need that requires accommodation, please let us know.

Recruitment & Staffing Agencies

Verve Therapeutics does not accept agency resumes unless contacted directly by internal Verve Talent Acquisition. Please do not forward resumes to Verve employees or any other company location; Verve Therapeutics is not responsible for any fees related to unsolicited resumes.

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