Preclinical/Translational Pharmacologist

2 weeks ago

Boston, United States Kojin Therapeutics Full time

We are seeking a preclinical/translational pharmacologist with experience in developing oncology small-molecule therapeutics. The ideal candidate would have solid experience in designing and conducting preclinical/translational pharmacology studies and be knowledgeable in molecular pathways involved in cell death and survival and experienced in conducting studies to elucidate the mechanisms of action of drug candidates. Prior experience in contributing to INDs and leading IND-enabling preclinical programs is highly desirable. You will conduct research to advance small-molecule therapeutics that work through novel ferroptosis mechanisms, and you will also be able to collaborate and communicate with medicinal chemists, biologists, DMPK and biomarker scientists, and nuclear medicine specialists to enable integration of knowledge across functions to effectively advance our pipeline.


The ideal candidate for this role will have demonstrated success in these responsibilities:

  • Interfacing with biologists, chemists, and DMPK scientists to design and conduct preclinical pharmacology studies as part of a project team, incorporating appropriate PK/PD and biomarker assessments as necessary at the appropriate stage of the program to enable development candidate selection and IND preparation, and to inform early clinical development.
  • Designing, conducting, and overseeing the execution of in vivo pharmacology and efficacy studies to support the IND (both in-house and at CROs). Providing oversight to a small team of scientists who are involved in conducting these studies.
  • Serving as the primary lead for IND enabling pharmacology package and working in collaboration with other project team members.
  • Help manage day-to-day operations of pharmacology lab and vivarium.
  • Initiating collaborations with external KOLs/ leaders in the field to generate human translational evidence to support the clinical programs.
  • Working with internal and external collaborators for indication expansion, collaborating with team members to generate data from preclinical studies to inform subsequent clinical development.
  • Authoring appropriate sections of regulatory documents and review documents such as IND, IB, CSRs.
  • Providing input into appropriate sections of clinical-protocol design, providing input to clinical development plan, and serving as member of clinical sub-team when needed.
  • Developing and providing input into biomarker strategy to enable successful clinical development as a part of the IDP including biomarkers to assess target engagement, pharmacodynamics, disease biomarkers and novel endpoints as appropriate for indication.
  • Incorporating metabolic imaging studies (e.g., PET/SPECT, MRI/MRS) into preclinical and clinical programs.


The ideal candidate for this role will have the following qualifications:

  • Ph.D. degree in cancer biology or related field of science.
  • At least 8 years of experience supporting discovery/development stage programs in oncology or related areas of science, ideally in biotech/pharma industry or CRO.
  • Experience working with cross-functional teams, writing, and authoring scientific and regulatory documents, protocols, reports, and IND filings.
  • Experience supporting and engaging with clinical development-stage programs, ability to approach and design projects from a preclinical to clinical translational perspective.
  • Demonstrated ability to collaborate with cross-functional colleagues, working with CROs, external collaborators/KOLs required.
  • Effective written and oral communications skills.
  • Demonstrated ability in taking initiative to develop relationships with internal and external collaborators.
  • Ability to collaborate in a multidisciplinary and dynamic environment and experience in mentoring and leading scientific programs.


Preferred qualifications but not required:

  • Clinical translational orientation, understanding of I/O and drug resistance mechanisms and models, biomarker considerations to enable patient selection/study design, and experience extrapolating relevant information from the preclinical program to the clinical-program design.
  • Previous regulatory interaction experience.
  • Experience in other diseases areas beyond oncology.


About Us

Kojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class, oral treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the Japanese deity that tamed fire for the good of humanity, Kojin is located in Boston's Seaport biotech neighborhood. We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis -- a newly discovered form of programmed cell death. Kojin is backed by a strong syndicate of top-tier investors, led by an experienced biotechnology and pharmaceutical-industry leadership team, and driven by creative dedicated professionals.


We accept submission of CVs directly from candidates but not from any third-party recruitment or staffing agencies.

  • Preclinical/Translational Pharmacologist

    3 weeks ago

    Boston, United States Kojin Therapeutics Full time

    We are seeking a preclinical/translational pharmacologist with experience in developing oncology small-molecule therapeutics. The ideal candidate would have solid experience in designing and conducting preclinical/translational pharmacology studies and be knowledgeable in molecular pathways involved in cell death and survival and experienced in conducting...

  • Molecular Pharmacologist

    3 weeks ago

    Boston, United States Kojin Therapeutics Full time

    We are seeking an initiative-taking, creative, and curious scientist to join our growing preclinical pharmacology team. The ideal candidate will have solid molecular pharmacology background related to cancer or other diseases, demonstrated experience in studying mechanisms involved in pathologies, drug mechanism of action, proficient in laboratory skills...

  • Molecular Pharmacologist

    3 weeks ago

    Boston, United States Kojin Therapeutics Full time

    We are seeking an initiative-taking, creative, and curious scientist to join our growing preclinical pharmacology team. The ideal candidate will have solid molecular pharmacology background related to cancer or other diseases, demonstrated experience in studying mechanisms involved in pathologies, drug mechanism of action, proficient in laboratory skills...

  • Associate Director, Translational Medicine

    2 days ago

    Boston, United States X4lifesciences Full time

    Job Title: Associate Director, Translational Medicine Company Overview: Join a dynamic and innovative clinical stage biotechnology company dedicated to developing novel small molecule therapeutics for oncology and immunology targets. Position Overview: We are seeking a highly motivated and experienced Associate Director, Translational Medicine to lead...

  • Associate Director, Translational Medicine

    5 days ago

    Boston, United States X4 Life Sciences Full time

    Job Title: Associate Director, Translational MedicineCompany Overview: Join a dynamic and innovative clinical stage biotechnology company dedicated to developing novel small molecule therapeutics for oncology and immunology targets.Position Overview: We are seeking a highly motivated and experienced Associate Director, Translational Medicine to lead...

  • Associate Director, Translational Medicine

    4 days ago

    Boston, United States X4 Life Sciences Full time

    Job Title: Associate Director, Translational MedicineCompany Overview: Join a dynamic and innovative clinical stage biotechnology company dedicated to developing novel small molecule therapeutics for oncology and immunology targets.Position Overview: We are seeking a highly motivated and experienced Associate Director, Translational Medicine to lead...

  • Research Fellow, Translational Optical Molecular Imaging

    3 weeks ago

    Boston, United States Mass General Brigham Full time

    Research Fellow, Translational Optical Molecular Imaging (Kumar Research)-(3273156) Description Research Fellow Positions Translational Optical Molecular Imaging Laboratory Mike Toth Research CenterMassachusetts Eye and Ear- Department of Otolaryngology-Head and Neck Surgery Harvard Medical School Boston MA Two research fellow...

  • Research Fellow, Translational Optical Molecular Imaging

    2 weeks ago

    Boston, United States Partners Healthcare System Full time

    Research Fellow Positions Translational Optical Molecular Imaging Laboratory Mike Toth Research Center Massachusetts Eye and Ear - Department of Otolaryngology-Head and Neck Surgery Harvard Medical School Boston MA Two research fellow positions are available in the translational optical molecular imaging Laboratory at the Toth Center, Department of...

  • Director/Senior Director, Clinical Pharmacology

    2 weeks ago

    Boston, United States Third Rock Ventures Full time

    As our clinical development portfolio evolves, Tango has an exciting new opportunity to join our team as a Director/Senior Director, Clinical Pharmacology. Reporting to our SVP, Pharmaceutical Sciences, you will be responsible for the design and implementation of clinical pharmacology aspects of patient trials and NDA-enabling clinical pharmacology studies....

  • Director/Senior Director, Clinical Pharmacology

    2 weeks ago

    Boston, United States Tango Therapeutics Full time

    Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at...

  • US Site Head

    3 weeks ago

    Boston, United States A fomous CRO Full time

    • Global management of preclinical pharmacology and translational pharmacology • Responsible for pre-clinical pharmacology and translational pharmacology research for drug discovery and development for immune oncology, immune / autoimmune disease and metabolic disease therapeutic areas to advance drug candidates from preclinical discovery to clinical...

  • US Site Head

    3 weeks ago

    Boston, United States A fomous CRO Full time

    • Global management of preclinical pharmacology and translational pharmacology • Responsible for pre-clinical pharmacology and translational pharmacology research for drug discovery and development for immune oncology, immune / autoimmune disease and metabolic disease therapeutic areas to advance drug candidates from preclinical discovery to clinical...

  • US Site Head

    3 weeks ago

    Boston, United States A fomous CRO Full time

    Global management of preclinical pharmacology and translational pharmacology Responsible for pre-clinical pharmacology and translational pharmacology research for drug discovery and development for immune oncology, immune / autoimmune disease and metabolic disease therapeutic areas to advance drug candidates from preclinical discovery to clinical...

  • Research Fellow

    3 days ago

    Boston, United States Partners Healthcare System Full time

    The Center for Precision Imaging (Director: Umar Mahmood, MD, PhD) at the Massachusetts General Hospital Martinos Center/Harvard Medical School has openings for highly qualified individuals at the post-doctoral level with strong background in preclinical PET molecular imaging and interest in molecular imaging of cancer. Our Center is at the forefront of...

  • Research Fellow

    2 days ago

    Boston, United States Mass General Physicians Organization(MGPO) Full time

    The Center for Precision Imaging (Director: Umar Mahmood, MD, PhD) at the Massachusetts GeneralHospital Martinos Center/Harvard Medical School has openings for highly qualified individuals at thepost-doctoral level with strong background in preclinical PET molecular imaging and interest inmolecular imaging of cancer. Our Center is at the forefront of...

  • Molecular Cell Biologists/Chemical Biologists

    3 weeks ago

    Boston, United States Kojin Therapeutics Full time

    We are seeking highly motivated, skilled, and collaborative scientists to join our growing biology team. The ideal candidates will be proficient in molecular and cellular biological skills and have a passion for contributing to drug discovery. Applicants with expertise in chemical biology and molecular biology will be given priority. The candidates should...

  • Research Lab Tech II DOM Men's Health

    2 weeks ago

    Boston, United States Brigham and Women's Hospital Full time

    Research Program in Men's Health: Aging and Metabolism seeks highly motivated and creative candidates for a full-time research position. The group works on the interface of biophysics, biochemistry and translational research to develop novel approaches to examine aging associated conditions. Specifically, the candidate will be responsible for...

  • Research Technician, Radiation Oncology

    2 weeks ago

    Boston, United States Massachusetts General Hospital Full time

    GENERAL SUMMARY/ OVERVIEW STATEMENT: The primary duty of the Research Technician is to conduct research focusing on the preclinical development of novel cancer therapeutics and translational studies to improve patient care. Specifically, the Research Technician will be responsible in performing the following tasks: 1) cell culture, 2) testing in vivo...

  • Research Assistant II

    2 weeks ago

    Boston, United States Boston Childrens Hospital Full time

    Job Posting DescriptionThe Jacobsen lab uses rare genetic bone disorders as a model to understand bone growth and development. We use mouse models, human derived pluripotent stem cells and human genetics. Our goal is to development new therapies for pediatric bone disease, especially pediatric osteoporosis and disorders of bone formation. Current therapies...

  • Investigative Veterinary Pathologist/Scientist

    7 days ago

    Boston, United States KP Recruiting Group Full time

    Job Description KP Recruiting Group is a consulting firm that provides leadership and exceptional talent to some of the world's leading companies. Headquartered in the Midwest, KP Recruiting Group has successfully completed countless engagements across the United States. We represent clients in all industries and all sizes. Our mission is to provide...