Head of Chemistry

3 months ago

Lexington, United States Orum Therapeutics Full time
Job DescriptionJob DescriptionSalary:

We are seeking an experienced Head of Bioconjugation/Chemistry to join our dynamic technology platform team. As a key leader, you will play a pivotal role in advancing our efforts in the discovery and development of cutting-edge oncology therapeutics by combining the power of targeted protein homeostasis with the precision of antibodies. We are looking for a candidate with a demonstrated track record of success in leading drug discovery projects, possessing a profound understanding of bioconjugation chemistry principles and drug discovery techniques, and a strong track record of delivering impactful portfolio achievements.

 

Principal Duties and Responsibilities.

  •  Formulate and implement innovative strategies to address critical project objectives, offering creative solutions for medicinal and synthetic chemistry challenges when working with novel protein degraders, linkers, and antibody-drug conjugates.
  • Collaborate proactively with various functional teams, including computational chemistry, DMPK, in vivo pharmacology, CMC, and more, to ensure the successful progression of drug discovery projects.
  • Identify, establish, and lead partnerships with CRO partners and implement strategies to improve operational efficiency and best practices.
  • Actively participate in the identification and nomination of emerging cancer targets at the forefront of the field and the establishment of new drug discovery programs in our portfolio.
  • Clearly and effectively communicate strategy and provide progress updates to cross-functional project teams and scientific leadership.
  • Contribute to the development and execution of IP strategy in collaboration with intellectual property attorneys.
  • Present and publish project results in external scientific meetings and peer-reviewed literature to enhance the company's scientific reputation.
  • Coach and mentor scientists across the discovery function, fostering their professional growth and enhancing organizational capabilities.


Skills, Abilities & Competencies

  • Expertise in communication with strategic partners, executive leadership, and KOLs.
  • Profound expertise in bioconjugation chemistry, including new and emerging linker and release trigger technologies, analytical methods, and structure-based design.
  • Current knowledge of synthetic and medicinal chemistry, with the ability to identify opportunities for advancing science in these fields.
  • High level of creativity and productivity, coupled with strong problem-solving skills.
  • Deep knowledge of ADME, physicochemical, biochemical, and pharmacological principles as applied to ADC discovery.
  • Extensive experience in collaborating closely with other functional areas, such as biology, computational chemistry, DMPK, in vivo pharmacology, CMC, and more.
  • A proven track record of portfolio success, having successfully guided projects to the identification of high-quality drug candidates.
  • Familiarity with various small molecules drug discovery modalities such as small molecule inhibitors, PPI inducers including PROTACs and MGs, etc. is a plus.
  • Collaborative team player with exceptional oral and written communication skills, including the ability to present rationale, data, issues, and accomplishments of the team.
  • Strong skills in gathering and analyzing competitive information from scientific sources such as patents and meetings and employing this information to guide program strategy.
  • Strong desire to mentor junior team members to increase their bioconjugation and medicinal chemistry knowledge and skill set.


Education- Ph.D. or equivalent degree in organic/medicinal chemistry or a related field with minimum 15+ years' industrial experience   


*U.S. citizens and those authorized to work in the U.S. (green card) are encouraged to apply. We are unable to sponsor at this time.

*Candidate must be able to pass a background investigation.

*Unable to work with 3rd party candidates or agencies.

 

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily within the context of the representative work environment and physical demands described above. Likewise, qualifications listed are representative of the knowledge, skills, and abilities required to perform the position’s essential functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


Orum Therapeutics is an Equal Opportunity Employer (EOE

  • Head of Administrative Services

    6 days ago

    Lexington, Kentucky, United States University Of Kentucky Full time

    Required License/Registration/Certification NonePhysical Requirements Ability to remain seated for extended periods while utilizing a keyboard, mouse, computer, and telephone. Ability to travel to meetings in various locations.Work Schedule Monday through Friday from 8:00 AM to 5:00 PM with occasional additional hours as necessary based on workload.Position...

  • Head of Institutional Research and Analytics

    7 hours ago

    Lexington, Kentucky, United States Commonwealth of Virginia Full time

    Position OverviewReporting to the Deputy Superintendent for Academics and Dean of the Faculty, the Director of Institutional Research, Assessment, and Analytics plays a crucial role in managing and reporting data to various state and federal entities. This position is responsible for maintaining a robust survey research program, overseeing faculty...

  • Assistant, Associate, or Professor in Clinical Pathology

    1 month ago

    Lexington, Kentucky, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Assistant, Associate, or Professor in Clinical Pathology Requisition Number FE03605 Working Title Clinical Pathologist/Clinical Chemist Department Name 7H600:PATHOLOGY Work Location Lexington, KY Type of Position Faculty Position Time Status Full-Time Tenure Track Status Non-Tenure Track Required Education...

  • Assistant, Associate, or Professor in Clinical Pathology

    1 month ago

    Lexington, Kentucky, United States University of Kentucky Full time

    University of KentuckyEqual Employment Opportunity/M/F/disability/protected veteran status.Posting Details Posting Details Job TitleAssistant, Associate, or Professor in Clinical PathologyRequisition NumberFE03605Working TitleClinical Pathologist/Clinical ChemistDepartment Name7H600:PATHOLOGYWork LocationLexington, KYType of PositionFacultyPosition Time...

  • Student Research Assistant

    3 weeks ago

    Lexington, Kentucky, United States University of Kentucky Full time

    Job TitleStudent Research Assistant - Plant and Soil SciencesRequisition NumberDU12554Department Name81060:PLANT AND SOIL SCIENCESWork LocationLexington, KYSalary Range$18.00 /hourType of PositionStudentPosition Time Status Part-TimeRequired EducationHS diploma, enrolled at UK.Required Related ExperienceChemistry and/or biology laboratory classesRequired...

  • Student Research Assistant

    3 weeks ago

    Lexington, United States University of Kentucky Full time

    Job TitleStudent Research Assistant - Plant and Soil SciencesRequisition NumberDU12554Department Name81060:PLANT AND SOIL SCIENCESWork LocationLexington, KYSalary Range$18.00 /hourType of PositionStudentPosition Time Status Part-TimeRequired EducationHS diploma, enrolled at UK.Required Related ExperienceChemistry and/or biology laboratory classesRequired...

  • Undergraduate Instructional Assistant for ChemExcel

    1 month ago

    Lexington, Kentucky, United States University of Kentucky Full time

    Job TitleUndergraduate Instructional Assistant for ChemExcel - Fall 2024Requisition NumberDU12423Department Name8E030:ChemistryWork LocationLexington, KYSalary Range$11.00 / hourType of PositionStudentPosition Time Status Part-TimeRequired EducationQualified applicant must be a current undergraduate UK student with sophomore status or higher; have a...

  • Assistant, Associate, or Professor in Otolaryngology

    3 months ago

    Lexington, Kentucky, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Assistant, Associate, or Professor in Otolaryngology Requisition Number FE03497 Working Title Basic Scientist Department Name 7H860:Otolaryngology Work Location Lexington, KY Type of Position Faculty Position Time Status Full-Time Tenure Track Status Tenure Track Required Education PhD, MD or MD/PhD Required...

  • Assistant, Associate, or Professor in Otolaryngology

    3 months ago

    Lexington, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Assistant, Associate, or Professor in Otolaryngology Requisition Number FE03497 Working Title Basic Scientist Department Name 7H860:Otolaryngology Work Location Lexington, KY Type of Position Faculty Position Time Status Full-Time Tenure Track Status Tenure Track Required Education PhD, MD or MD/PhD Required...

  • Assistant, Associate, or Professor in Otolaryngology

    1 month ago

    Lexington, Kentucky, United States University of Kentucky Full time

    University of KentuckyEqual Employment Opportunity/M/F/disability/protected veteran status.Posting Details Posting Details Job TitleAssistant, Associate, or Professor in OtolaryngologyRequisition NumberFE03497Working TitleBasic ScientistDepartment Name7H860:OtolaryngologyWork LocationLexington, KYType of PositionFacultyPosition Time Status Full-TimeTenure...

  • Student/Non-work Study

    4 weeks ago

    Lexington, United States University of Kentucky Full time

    Job TitleStudent/Non-work StudyRequisition NumberDU12533Department Name7H400:Microbiology, Immunology & Molecular GenWork LocationLexington, KYSalary Range$9.00 - $15.00/hourType of PositionStudentPosition Time Status Part-TimeRequired EducationHigh School DiplomaRequired Related ExperienceN/ARequired License/Registration/CertificationN/APhysical...

  • Senior Scientist

    2 months ago

    Lexington, United States Novo Nordisk AS Full time

    About the Department The Molecular AI team is part of Novo Nordisk’s Computational Drug Design (CDD) area where we apply and develop state of the art capabilities in predictive science, AI/ML and structure-based drug design. Scientists within CDD collaborate seamlessly with teams across the globe to invent better molecules faster. With an unbiased...

  • Laboratory Technician Senior

    3 weeks ago

    Lexington, Kentucky, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Laboratory Technician Senior Requisition Number RE46778 Working Title Lab Tech Department Name 81070:ANIMAL AND FOOD SCIENCES Work Location Lexington, KY Grade Level 40 Salary Range $ /hour Type of Position Staff Position Time Status Full-Time Required Education BS Click here for more information about...

  • Senior Scientist

    2 months ago

    Lexington, Kentucky, United States Novo Nordisk Full time

    About the Department The Molecular AI team is part of Novo Nordisk's Computational Drug Design (CDD) area where we apply and develop state of the art capabilities in predictive science, AI/ML and structure-based drug design. Scientists within CDD collaborate seamlessly with teams across the globe to invent better molecules faster. With an unbiased approach...

  • Head of Research, Assessment, and Analytics

    6 days ago

    Lexington, Kentucky, United States Commonwealth of Virginia Full time

    Position Overview As a key member of the academic leadership team, the Director of Institutional Research, Assessment, and Analytics plays a vital role in the strategic management of data reporting to governmental bodies. This position is responsible for overseeing a comprehensive survey research initiative, managing faculty evaluations, and ensuring...

  • Nurse Clinical/UKHC

    1 month ago

    Lexington, Kentucky, United States University of Kentucky Full time

    Job TitleNurse Clinical/UKHCRequisition NumberNR12866Working TitleRN/Head, Neck & Respiratory ClinicDepartment NameM3030:Cancer Clinic ServicesWork LocationLexington, KYGrade Level10Salary Range$ /hourType of PositionStaffPosition Time Status Full-TimeRequired EducationADNRequired Related ExperienceNo experience required.Required...

  • Nurse Clinical/UKHC

    2 months ago

    Lexington, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Nurse Clinical/UKHC Requisition Number NR12608 Working Title RN/Head, Neck & Respiratory Clinic Department Name M3030:Cancer Clinic Services Work Location Lexington, KY Grade Level 10 Salary Range $23.25-39.10/hour Type of Position Staff Position Time Status Full-Time Required Education ADN Required Related...

  • Nurse Clinical/UKHC

    1 month ago

    Lexington, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Nurse Clinical/UKHC Requisition Number NR12866 Working Title RN/Head, Neck & Respiratory Clinic Department Name M3030:Cancer Clinic Services Work Location Lexington, KY Grade Level 10 Salary Range $23.25-39.10/hour Type of Position Staff Position Time Status Full-Time Required Education ADN Required Related...

  • Nurse Clinical/UKHC

    2 months ago

    Lexington, United States University of Kentucky Full time

    Posting DetailsPosting Details Job Title Nurse Clinical/UKHC Requisition Number NR12609 Working Title RN/Head, Neck & Respiratory Clinic Department Name M3030:Cancer Clinic Services Work Location Lexington, KY Grade Level 10 Salary Range $23.25-39.10/hour Type of Position Staff Position Time Status Full-Time Required Education ADN Required Related...

  • STEPS Lab Technician

    2 months ago

    Lexington, United States University of Kentucky Part time

    Posting DetailsPosting Details Job Title STEPS Lab Technician Requisition Number TE08401 Department Name H3200:Laboratory Services Work Location Lexington, KY Salary Range 28.00 Type of Position Temporary Position Time Status Part-Time Required Education Required Related Experience Required License/Registration/Certification Physical Requirements...