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Senior Scientist I

2 months ago

Bryan, United States Matica Biotechnology, Inc. Full time
Job DescriptionJob DescriptionMatica Biotechnology is at the forefront of biopharmaceutical research and development. The Matica Bio team brings an average of 15 years of cell and viral vector manufacturing experience to the development and manufacture of advanced therapy products. At our purpose-built GMP facility in College Station, Texas, we provide rapid development and scale-up of cell and gene therapies, vaccines, and Oncolytics meeting worldwide regulatory compliance.

The true value of a CDMO is determined by the quality of its people. Matica Bio consists of a dedicated team of experts. We’re a cell and gene therapy CDMO powered by people, and our people provide real benefits to the quality, safety and speed of the cell and gene therapy development pathway. Our inventive thinking and foresight help us strategize the best path to take therapies from the lab to the market. Come join our dedicated team and Make it Happen With Matica Bio

Position Opportunity:

The Senior Scientist I (AAV, Lenti), Downstream Process Development will contribute to Process Development within a project team to provide experimental design and planning and work in the development, evaluation, and characterization of downstream processes to produce novel therapeutic products. This position will be primarily focused on the utilization of adeno-associated viruses (AAV) and Lentivirus for developing Gene Therapies. The role will function as a subject matter expert (SME) in AAV and Lentivirus for the Process Development team collaborating with stake holders inside and outside of the company and must be able to communicate project updates orally and through written presentations to both clients and management. This role will include acting as a teacher and mentor for junior scientists through training and coaching. This position is in the Bryan-College Station area and expectation is to be on site five business days a week or as required.

How you will make an impact:

  • Identify, design, execute and analyze experimental protocols and present results to senior leadership, clients, and team members, focusing on AAV and Lentivirus.
  • Serve as a subject matter expert for downstream AAV and Lentivirus processes and closely collaborate with the upstream Process Development team.
  • Authoring and revising: SOPs, data presentations, study designs, protocols, and reports.
  • Assess manufacturing processes supplied by client companies for suitability for GMP manufacture and identify any scale-up requirements/issues.
  • Assist in the technology transfer process to enable clinical manufacture, using novel processes, within the GMP environment. This will require collaboration with the manufacturing team providing technical assistance as the subject matter expert.
  • Work as part of the Process Development team building internal platforms.
  • Operate and maintain a variety of lab equipment including, but not limited to, tangential flow filtration (TFF), chromatography equipment, automated cell counters, bio-analyzers, microscopes, pumps, bioreactors, scales, tubing welders/sealers and pH/conductivity meters.
  • Utilization of excellent communication skills to collaborate across all company functions and in client interfacing meetings.

As a future Matican you bring:

Education:

  • A minimum of a bachelor’s degree in a scientific discipline e.g., Biology, Biochemistry, Virology, or equivalent.
  • Additional consideration will be given to advanced degrees with a relevant focus.

Experience:

  • 3+ years concentrated in AAV and Lentivirus viral vector technology for gene therapy Process Development required.
  • 6+ years in a Process Development role or a combination of development and cGMP manufacturing preferred. Experience working in a cGMP environment, in the biotech industry.
  • Experience utilizing Cytiva/AKTA a plus.

Skills:

  • Collaborative team player
  • Attention to detail
  • Ability to wear appropriate PPE
  • Good verbal and written communication skills
  • Integrity, discretion, and confidentiality
  • Computer software skills, organization, record keeping, and planning
  • Maintain clean room facilities

Qualities and attitude:

  • Strong work ethic with good written and oral communication, ability to work collaboratively and respectfully within a team and across departments
  • Proactive and self-motivated
  • Positive attitude and committed to Matica Bio’s success
  • Dedication to continual learning and sharing of knowledge

Competencies we look for:

Commitment to Excellence, Problem Solving/Decision Making/Analytical Thinking, Communication Skills, Teamwork/Cooperation/Supportiveness, Flexibility/Adaptability, Initiative/Taking Ownership, Focus on Safety, Ethical/Trustworthiness, Work Ethic/Reliability, Thoroughness, Customer Service

We Value:

Matica’s Values are at the forefront of everything we do, our culture, and the decisions we make.

  • Start with Safety & Quality
  • Choose the Path of Openness, Honesty, and Integrity
  • Nurture Our Differences to Enable Our Collective Success
  • Learn Continuously to Ensure Our Value and Relevance
  • Commit to Delivering Life Altering Therapies