Senior Fermentation Scientist

3 weeks ago

Redwood City, United States HK Recruiting Full time
Job DescriptionJob Description

The Senior Fermentation Scientist will join our Upstream Bioprocess Development team and will be responsible for the design & execution of fermentation experiments for development of new bioprocesses. The person will play a leading technical role in project management of fermentation programs within the group. In addition, the Sr. Scientist will be responsible for tech transferring bioprocesses to CRO/CMOs. They will collaborate cross-functionally with members of the Technical Operations team. The position will be on-site in Redwood City.

If any of the below describes you, we would love to meet you

  • Passionate about Fermentation and the role it plays in translating scientific discovery into commercial reality.
  • Enjoys cross-functional collaboration, teamwork, and mentorship. In addition, has a passion for technical project management.
  • Enjoys fermentation process development and microbial physiology (E. coli focus)
  • Strong safety mindset in a fermentation environment and have a strong attention to detail.

In this role you will be responsible for:

  • Lead the development of new fermentation bioprocesses utilizing E. coli as an expression host for production of enzymes for Pharmaceutical Manufacturing & Life Science applications.
  • Hands-on running bench-scale bioreactors (250 mL, 2 L, & 10 L), performing bench experiments, and providing mentorship/management to other team members within the bioprocess group.
  • Lead the authorship of tech transfer packages and transferring processes to CRO/CMOs.
  • Perform Design of Experiments (DOEs) and data analysis with strong scientific and statistical rigor.
  • Supervising Research Associates & Engineers in the bioprocess development group.
  • Following safety best practices and leading implementation of new safety processes.
  • Routinely present technical information to various audiences both internal and external to Bioprocess Development.

The essential requirements of the job include:

  • Ph.D. in Chemical Engineering, Microbiology, Microbial Physiology, or related discipline with a minimum of 5 years of relevant industry experience; M.S or B.S. with at least 8-10 years relevant experience, respectively.
  • Strong understanding of microbial physiology (with a focus on E. coli) and its intersection with fermentation processes at bench scale (≤10L).
  • Previous hands-on experience with bench scale fermentation for production of recombinant proteins in E. coli.
  • Experience with leading multiple fermentation-focused projects simultaneously and technical program management.
  • Experience utilizing graphical software (JMP, R, Python, or similar) and motivated in handling large data sets from high throughput fermentation platforms to make data-driven decisions.

Additional experience that would be valuable for this role includes:

  • Previous experience working with and providing oversight to CRO/CMOs.
  • Experience working under a quality system (e.g. ISO, GMP) or manufacturing experience/exposure.
  • Hands-on experience with primary recovery of enzymes and knowledge of downstream purification unit operations.
  • Knowledge of automation systems and using liquid handling equipment and assays to support fermentation process analytics.
  • Experience managing/mentoring Engineers, and Research Associates performing fermentation process development workflows.

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