Associate Scientist, Structural Biology

3 weeks ago


Redwood City, United States Revolution Medicines, Inc. Full time

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a Senior Research Associate/Associate Scientist to join the Structural Biology (X-Ray Crystallography/CryoEM) team to support multiple oncology therapeutic programs. Working from the bench, they will apply their expertise in protein purification to form compound driven complexes, identify and optimize crystallization/CryoEM conditions with the aim of determining high resolution structural information to drive small molecule design.

Responsibilities:

* Preparation of protein complexes for structural analysis (Crystallography/CryoEM)


* Operate laboratory robotics for preparing and inspection of crystallization trials.


* Communicate experimental design and results to cross-functional teams.


* Manage and document experiments.



Required Skills, Experience and Education:

* MSc. degree with 5+ years of experience or BSc. degree and a minimum of 8 years of experience


* Experience with protein purification (AKTA) and/or biophysical characterization (Thermal melt, CD, SPR, anSEC).


* Experience with protein-protein complexes including antibodies/Fabs, molecular glues, PROTACs, etc.


* Experience with growing and harvesting protein crystals, preparing samples for CryoEM, prior use of structure determination/visualization software (CCP4, Phenix, Coot, PyMOL, Chimera), and/or CryoEM (Relion. CryoSPARC) are highly desirable skills.


* Demonstrated ability to follow written protocols and document research progress.


* Excellent written and verbal communication skills.


* Conscientious team-player interested in a fast-paced biotech environment.


* Demonstrated willingness to learn and improve processes.



Preferred Skills, Experience and Education:

* Experience with biophysical characterization such as MS, SPR, NMR a plus.


* Experience in protein expression including construct design and protein engineering.



The expected salary range for this role is $100,000 to $135,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.



  • Iowa City, United States University of Iowa Full time

    For additional information about the Department of Biochemistry and Molecular Biology at the University of Iowa, please visit our website at: BASIC QUALIFICATIONS PhD in chemistry, biochemistry, structural biology, or related scientific discipline. P Research Scientist, Chemistry, Biology, Biochemist, Chemist, Assistant, Technology, Education


  • Redwood City, United States Adverum Biotechnologies, Inc. Full time

    Adverum is looking for a highly motivated AAV Vector Production Research Associate/Associate Scientist to join our Research team at our Redwood City, CA office. The successful candidate will play a critical role in planning and executing the production of AAV viral vectors and their application to Adverum's gene therapy pipeline of products. The incumbent...


  • Redwood City, United States Adverum Biotechnologies, Inc. Full time

    Adverum is looking for a highly motivated AAV Vector Production Research Associate/Associate Scientist to join our Research team at our Redwood City, CA office. The successful candidate will play a critical role in planning and executing the production of AAV viral vectors and their application to Adverum's gene therapy pipeline of products. The incumbent...


  • Redwood City, United States Adverum Biotechnologies, Inc. Full time

    Adverum is a clinical stage AAV-based gene therapy company targeting unmet medical needs in ocular and rare diseases. We are seeking a highly motivated and collaborative Research Associate/Associate Scientist/Scientist with experience in ocular biology to join our team in our Redwood City office. The successful candidate will play a critical role in the...


  • Redwood City, United States Adverum Biotechnologies, Inc. Full time

    Adverum is a clinical stage AAV-based gene therapy company targeting unmet medical needs in ocular and rare diseases. We are seeking a highly motivated and collaborative Research Associate/Associate Scientist/Scientist with experience in ocular biology to join our team in our Redwood City office. The successful candidate will play a critical role in the...


  • Redwood City, California, United States Advanced Clinical Full time

    OVERVIEWWe are currently searching for a skilled professional to join a well-known client's team as a Director Discovery, Biology in Redwood City, California. Reporting to the VP of Cancer Biology, this role will lead a research group of chemical biologists, biochemists, and cell biologists focused on cancer targets and drug mechanisms. If you are a...


  • Redwood City, California, United States Advanced Clinical Full time

    OVERVIEWWe are currently searching for a skilled professional to join a well-known client's team as a Director Discovery, Biology in Redwood City, California. Reporting to the VP of Cancer Biology, this role will lead a research group of chemical biologists, biochemists, and cell biologists focused on cancer targets and drug mechanisms. If you are a...


  • Redwood City, United States Galvanize Therapeutics, Inc. Full time

    Galvanize is a biomedical platform company operating at the convergence of engineering, biology, and healthcare delivery, aiming to deliver life-changing solutions to patients and their doctors. We design and develop Pulsed Electric Field Systems to achieve meaningful and lasting therapeutic outcomes for patients.General Description The Associate Research...


  • Redwood City, United States Galvanize Therapeutics, Inc. Full time

    Galvanize is a biomedical platform company operating at the convergence of engineering, biology, and healthcare delivery, aiming to deliver life-changing solutions to patients and their doctors. We design and develop Pulsed Electric Field Systems to achieve meaningful and lasting therapeutic outcomes for patients.General Description The Associate Research...


  • Foster City, United States NexInfo Solutions, Inc. Full time

    Job Title Research Associate Biology - Onsite in Foster CityContract duration: 6 monthsRelocation will not be provided for this position. Job Description:We are seeking a highly motivated in vivo research associate to join our Inflammation group as a contractor. The selected candidate will support in vivo scientists to execute preclinical studies, whether...

  • Associate Scientist

    2 weeks ago


    Redwood City, United States R&D Partners Full time

    Biotechnology company is hiring an Associate Scientist with knowledge of molecular biology to join the Research, Development and Discovery team. You will develop, characterize, and validate optogenetic gene therapy vectors and assist with IND-enabling studies. This is a 6 month contract with an opportunity for an extension.ResponsibilitiesSupport the...

  • Associate Scientist

    1 week ago


    Redwood City, United States R&D Partners Full time

    Biotechnology company is hiring an Associate Scientist with knowledge of molecular biology to join the Research, Development and Discovery team. You will develop, characterize, and validate optogenetic gene therapy vectors and assist with IND-enabling studies. This is a 6 month contract with an opportunity for an extension.ResponsibilitiesSupport the...

  • Associate Scientist

    1 week ago


    Redwood City, United States R&D Partners Full time

    Biotechnology company is hiring an Associate Scientist with knowledge of molecular biology to join the Research, Development and Discovery team. You will develop, characterize, and validate optogenetic gene therapy vectors and assist with IND-enabling studies. This is a 6 month contract with an opportunity for an extension.ResponsibilitiesSupport the...

  • Associate Scientist

    2 weeks ago


    Redwood City, United States R&D Partners Full time

    Biotechnology company is hiring an Associate Scientist with knowledge of molecular biology to join the Research, Development and Discovery team. You will develop, characterize, and validate optogenetic gene therapy vectors and assist with IND-enabling studies. This is a 6 month contract with an opportunity for an extension.ResponsibilitiesSupport the...


  • Redwood City, California, United States Adverum Biotechnologies Full time

    Adverum is a clinical stage AAV-based gene therapy company targeting unmet medical needs in ocular diseases. We are seeking a highly motivated and collaborative Senior Research Associate / Associate Scientist with molecular and cellular biology experience to join our team in our Redwood City office. This individual will work in a cross-functional team to...

  • Scientist II

    1 week ago


    Redwood City, California, United States Codexis, Inc. Full time

    Department64 - QC & Analytical DevelopmentEmployment TypeFull TimeLocationRedwood City, CAWorkplace typeOnsiteReporting ToNianliu ZhangDescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Scientist II. Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver technology platform to discover,...


  • Redwood City, United States Longevitylist Full time

    Autonomous Research Process Scientist/Engineer Retro develops therapies for diseases driven by the biology of aging. We work on (1) partial reprogramming, (2) blood factors, and (3) autophagy to rejuvenate and restore function to cells, tissues, and organisms. We are looking for a Process Scientist/Engineer generalist to build our Autonomous Research...

  • Scientist II

    3 weeks ago


    Redwood City, United States Codexis, Inc. Full time

    Department 64 - QC & Analytical Development Employment Type Full Time Location Redwood City, CA Workplace type Onsite Reporting To Nianliu Zhang DescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Scientist II.  Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver®...

  • Scientist II

    1 week ago


    Redwood City, United States Codexis, Inc. Full time

    Department 64 - QC & Analytical Development Employment Type Full Time Location Redwood City, CA Workplace type Onsite Reporting To Nianliu Zhang DescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Scientist II.  Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver®...

  • Associate Scientist

    4 weeks ago


    Kansas City, United States Stowers Institute for Medical Research Full time

    The Electron Microscopy Center at the Stowers Institute for Medical Research has an opening for an Associate Scientist to support researchers at the Institute using state-of-the-art Electron Microscopy and X-ray-based micro-CT imaging equipment. This role will include collaborative meetings for experimental design, sample processing/cutting/mounting,...