Associate Scientist, Structural Biology

3 weeks ago

Redwood City, United States Revolution Medicines, Inc. Full time

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding scientists in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are looking for a Senior Research Associate/Associate Scientist to join the Structural Biology (X-Ray Crystallography/CryoEM) team to support multiple oncology therapeutic programs. Working from the bench, they will apply their expertise in protein purification to form compound driven complexes, identify and optimize crystallization/CryoEM conditions with the aim of determining high resolution structural information to drive small molecule design.

Responsibilities:

* Preparation of protein complexes for structural analysis (Crystallography/CryoEM)


* Operate laboratory robotics for preparing and inspection of crystallization trials.


* Communicate experimental design and results to cross-functional teams.


* Manage and document experiments.



Required Skills, Experience and Education:

* MSc. degree with 5+ years of experience or BSc. degree and a minimum of 8 years of experience


* Experience with protein purification (AKTA) and/or biophysical characterization (Thermal melt, CD, SPR, anSEC).


* Experience with protein-protein complexes including antibodies/Fabs, molecular glues, PROTACs, etc.


* Experience with growing and harvesting protein crystals, preparing samples for CryoEM, prior use of structure determination/visualization software (CCP4, Phenix, Coot, PyMOL, Chimera), and/or CryoEM (Relion. CryoSPARC) are highly desirable skills.


* Demonstrated ability to follow written protocols and document research progress.


* Excellent written and verbal communication skills.


* Conscientious team-player interested in a fast-paced biotech environment.


* Demonstrated willingness to learn and improve processes.



Preferred Skills, Experience and Education:

* Experience with biophysical characterization such as MS, SPR, NMR a plus.


* Experience in protein expression including construct design and protein engineering.



The expected salary range for this role is $100,000 to $135,000. An individual's position within the range may be influenced by multiple factors, including skills and experience in role, overall performance, individual impact and contributions, tenure, and market dynamics. Base salary is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

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