Senior/Principal Research Associate Research, Mass Spectrometry and Proteomics

3 weeks ago

Cambridge MA United States Flare Therapeutics Full time

Flare Therapeutics is a biotechnology company pioneering a new therapeutic space with a novel approach to decipher the biology of transcription factors to develop small molecule medicines. Based on insights from the seminal work of its scientific founders, Flare’s team has uncovered ‘switch sites,’ druggable regions that are key targets for transcription factor regulation, to address mutations that cause disease. Flare’s drug discovery efforts to target switch sites has rapidly advanced, resulting in an emerging pipeline of research programs that address well-validated genetically-defined transcription factors, initially focused on precision oncology with future potential in neurology, rare genetic disorders, immunology and inflammation.

We are a collective of brilliant fires, trailblazing a path to conquer transcription factors and create cutting-edge medicines for patients. We embrace diversity in all its forms, experiences, and viewpoints. We are inspired by the unknown and willing to take risks. We are passionate about the science we pursue and compassionate about the patients it stands to benefit. And we respect, value, and believe in each other.


In this role you will…
  • Execute experiments to inform target engagement on transcription factors using a variety of approaches which include tissue cell culture, automated workflows and characterization using mass-spectrometry based proteomics.
  • Execute high-throughput global proteomics characterization of transcription factors using isotope labeling, TMT, alternative proteases, targeted proteomics (PRM or equivalent) and data-independent acquisition (DIA) workflows.
  • Generate data in a timely manner; support lead discovery initiatives and regularly contribute at the bench.
  • Work closely with senior staff to set experimental strategy, project goals, and timelines to drive projects toward successful completion.
  • Work closely with biology, biochemistry, chemistry and compound management teams in early discovery to optimize screening on high-value transcription factors.
About you…
  • You have a B.S or M.S in chemical biology, biochemistry or analytical chemistry.
  • You have 1-3 years of experience in industry.
  • You have knowledge of proteomics principles and hands-on experience in mass spectrometry-based quantitative proteomics that includes DDA, DIA and/or LFQ.
  • You may have experience in targeted proteomics and TMT-based workflows.
  • You may also have understanding of proteomics sample preparations using both 96- and 384-well plate formats.
  • You may have prior experience with assay development, sample prep automation, HPLC fractionation.
  • You have a desire to work in a lab-based role within a highly adaptive, fast-paced collaborative environment and can creatively solve problems through innovation and communication.
  • You have self-motivation, great decision making, organizational, analytical, interpersonal and communication skills.

Flare Therapeutics is proud to foster a diverse, equitable and inclusive company culture that embraces all people that are essential to who we are, what we do and what we believe. Flare Therapeutics is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

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