Associate Scientist III, Protein Characterization

6 days ago

Redwood City CA United States Adverum Biotechnologies Full time
Redwood City, CA Assay Development Full Time Protein Characterization Associate Scientist III will report to Director-level personnel in Assay Development to support Quality Control, Process Development, and other CMC departments. This role is responsible for building, optimizing, and maintaining chromatographic and biophysical assays in support of gene therapy product release and characterization. This role is expected to be at least 80% on site at our Redwood City location and at most 20% remote. What you'll do:
  • Lead development, qualification, validation, and transfer of chromatographic and biophysical assays in some or all following categories: 1) Chromatography, including SEC, AEX, RP, and AF4 2) Light scattering applications, including DLS and MALS 3) Capillary electrophoresis, including CE-SDS, CE-LIF, and icIEF 4) Mass spectrometry applications, including intact LC-MS, peptide-mapping LC-MS/MS, and quantitative LC-MS/MS with MRM
  • Lead conception, design, and execution of robustness testing
  • Lead pilot forced degradation projects
  • Lead transfer of processes, technology, and assays to/from internal and external labs
  • Oversee assay development, testing, and troubleshooting at internal and external labs
  • Evaluate, implement, and optimize new technology within Assay Development to support product extended characterization
  • Present results, conclusions, and implications to cross-functional teams and senior management to support data-driven decision making
  • Participate in external scientific meetings
  • Author test procedures, standard test methods, SOPs, protocols, and technical reports
  • Serve as a subject matter expert for chromatographic and biophysical assays
  • Train and mentor junior personnel in technical areas
  • Maintain a detailed awareness of industry regulatory guidance and standards for assay validation and performance
  • Maintain current knowledge of advancing technologies and propose their applications to ongoing projects.
  • Maintain excellent documentation of laboratory activities
  • Perform routine lab maintenance
  • Other responsibilities may be assigned as neededAbout you:
    • Associate Scientist: Master's degree with 8+ years or Bachelor's degree with 10-12 years of relevant biotechnology industry experience.
    • Experience in assay development is required
    • Ability to read and extract information from published literature and internal reports is required
    • Expertise is required in some or all of the following techniques: HPLC, AF4, CE, DLS, and MALS, LC-MS, and LC-MS/MS
    • Experience in the qualification/validation of quantitative assays and knowledge of FDA requirements is strongly desired
    • Broad knowledge of protein, cell, or nucleic acid assay methods and biochemistry with application to gene therapy is strongly desired
    • Experience working with AAVs is a plus.
    • Expertise in BLI, DSF, AUC, or BMI is desirable but not essential.
    • Must be a self-starter, proactive, co-operative, and proficient at working both independently and in a small team environment
    • Proven initiative and demonstrated accountability in a fast-paced environment with high degree of flexibility
    • Detail oriented and with time management skills
    • Excellent verbal and written communication skills
    • Experience in presenting data through written reports and oral presentation; publication in a peer-reviewed journal or presentation at a conference is desired
    • Proficiency with Empower, Dynamics, Astra, and other common analytical software desired
    • Proficient with MS Office and other common office software About Us Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum's core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control. At Adverum, -Inclusion -and -Diversity -are at our core. We believe in the power of being your authentic self. We strive to create the space which allows for everyone in our Adverum -Community -to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation
      #J-18808-Ljbffr

  • Senior Principal Scientist

    2 weeks ago

    Redwood City, California, United States Bristol-Myers Squibb Full time

    About the RoleWe are seeking a highly skilled and experienced scientist to join our team as a Senior Principal Scientist in Protein Structure Prediction. As a key member of our Informatics and Predictive Sciences (IPS) team, you will be responsible for developing and implementing innovative computational approaches and workflows to predict, design, and...

  • Research Associate III

    3 months ago

    Redwood City, United States Codexis, Inc. Full time

    Department 47 - Protein Engineering Employment Type Full Time Location Redwood City, CA Workplace type Onsite DescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Research Associate III – Protein Engineering.  Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® technology...

  • Scientist Assay Technology

    3 weeks ago

    Redwood City, United States Planet Pharma Full time

    Scientist Assay Technology - Lead Discovery The Opportunity We are looking for an experienced Associate Scientist/Scientist I to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical and biophysical screening techniques to drive...

  • Scientist II

    7 days ago

    Redwood City, CA, United States Codexis, Inc. Full time

    Scientist II - Analytical DevelopmentDepartment: 64 - QC & Analytical DevelopmentEmployment Type: Full TimeLocation: Redwood City, CAReporting To: Nianliu ZhangDescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Scientist II. Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver...

  • Scientist II

    1 month ago

    Redwood City, United States Codexis, Inc. Full time

    Department 64 - QC & Analytical Development Employment Type Full Time Location Redwood City, CA Workplace type Onsite Reporting To Nianliu Zhang DescriptionCodexis, a biotechnology company based in Redwood City, CA, is looking to hire a Scientist II.  Codexis is a leading enzyme engineering company leveraging its proprietary CodeEvolver® technology...

  • Sr. Associate Scientist

    1 day ago

    Bothell, WA, United States Pioneer Data Systems Full time

    Our client, a world-leading Pharmaceutical Company in Bothell, WA is currently looking for a Sr. Associate Scientist to join their expanding team.Position Details:Job Title: Sr. Associate Scientist / Protein Purification / Pharma IndustryDuratio

  • Scientist Assay Technology Lead Discovery

    2 days ago

    Redwood City, California, United States Planet Pharma Full time

    The OpportunityWe are seeking an experienced Associate Scientist/Scientist I to accelerate our search for new oncology therapeutics in the Discovery Sciences team.The successful candidate will join a high-performing team of experts in biochemical and biophysical screening techniques to drive the efficient identification and rapid development of clinically...

  • Scientist, Purification Development

    7 days ago

    San Diego, CA, United States Web-atrio Full time

    SUMMARY:The Scientist in Purification Development is responsible for all aspects of protein purification process development from process definition to commercialization of pipeline projects. The candidate must have hands-on working experience in applying engineering and scientific principles in purification process optimization, process characterization,...

  • Senior Scientist

    2 weeks ago

    Redwood City, California, United States Planet Pharma Full time

    Job Title: Senior Scientist - Assay TechnologyPlanet Pharma is seeking a highly skilled Senior Scientist to join our Discovery Sciences team. As a key member of our team, you will be responsible for designing and executing lead discovery screening methods and experiments to identify compound hits and advance them through hit-to-lead and lead optimization...

  • Senior Scientist

    11 hours ago

    redwood city, United States R&D Partners Full time

    Biotechnology company is hiring a full-time Senior Scientist to contribute to process characterization efforts to support pipeline programs. The candidate will be responsible for preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. You will have significant laboratory...

  • Senior Scientist

    1 week ago

    Redwood City, United States R&D Partners Full time

    Biotechnology company is hiring a full-time Senior Scientist to contribute to process characterization efforts to support pipeline programs. The candidate will be responsible for preparation, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. You will have significant laboratory...

  • Senior Research Associate, Assay Technology

    3 days ago

    Redwood City, California, United States Planet Pharma Full time

    Job OpportunityWe are seeking a highly skilled Senior Research Associate to join our Discovery Sciences team at Planet Pharma. As a key member of our team, you will play a crucial role in accelerating our search for new oncology therapeutics.Key ResponsibilitiesDesign and execute lead discovery screening methods and experiments to identify compound hits and...

  • Biochemist Research Scientist

    3 weeks ago

    Redwood City, California, United States Planet Pharma Full time

    Job SummaryWe are seeking a highly skilled Biochemist Research Scientist to join our Discovery Sciences team at Planet Pharma. As a key member of our team, you will play a critical role in accelerating our search for new oncology therapeutics.Key ResponsibilitiesDesign and execute lead discovery screening methods and experiments to identify compound hits and...

  • Senior Research Associate, Assay Technology

    3 weeks ago

    Redwood City, United States Planet Pharma Full time

    The Opportunity Senior Research Associate, Assay Technology - Lead Discovery We are looking for an experienced Research Associate/Senior Research Associate to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical and biophysical...

  • Senior Biotechnology Specialist

    5 days ago

    Redwood City, California, United States Adverum Biotechnologies Full time

    About the RoleWe are seeking an experienced Associate Scientist III to join our Assay Development team at Adverum Biotechnologies. As a key member of our team, you will be responsible for building, optimizing, and maintaining chromatographic and biophysical assays in support of gene therapy product release and characterization.Key ResponsibilitiesLead the...

  • Senior Research Associate, Assay Technology Lead

    2 weeks ago

    Redwood City, California, United States Planet Pharma Full time

    About the RoleWe are seeking an experienced Research Associate/Senior Research Associate to join our Discovery Sciences team at Planet Pharma. As a key member of our team, you will play a critical role in accelerating our search for new oncology therapeutics.Key ResponsibilitiesDesign and execute lead discovery screening methods and experiments to identify...

  • Associate Research Scientist

    6 days ago

    New York City, United States The Judith Sulzberger Genome Center at the Columbia University Medical Center Full time

    The Honig Lab within the Department of Systems Biology is seeking to hire an Associate Research Scientist to play a central role in the development of scientific tools that will lead to the next generation of our PrePPI and P-HIPSter computational pipelines that predict protein-protein interactions on a genomic scale. The research will involve mastering the...

  • Scientist - Bioinformatics, Computational Biology, Proteomics

    4 days ago

    San Francisco, CA, United States Kiaatlantasouth Full time

    Scientist - Bioinformatics, Computational Biology, Proteomics in South San Francisco , California HOW MIGHT YOU DEFY IMAGINATION?You've worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission-to...

  • Research Scientist III

    2 days ago

    CA-Emeryville, United States GRIFOLS, S.A. Full time

    table.MiTabla { max-width: 1020px;!important Would you like to join an international team working to improve the future of healthcare? Do you want to enhance the lives of millions of people? Grifols is a global healthcare company that since 1909 has been working to improve the health and well-being of people around the world. We are leaders...

  • Associate Scientist I

    5 days ago

    Seattle, WA, United States Lumen Bioscience Full time

    Summary:The Associate Scientist will work with and support scientists in the Biologics research and development team. The work will focus on designing, validating, characterizing, and conducting a wide range of microbial and bacterial assays to support Lumen's therapeutic objectives. The candidate will play a key role in microbiology, molecular biology, and...