Senior Principal Scientist, Veterinary Pathology

3 weeks ago


West Point MS United States Merck Sharp & Dohme Full time

Job Description

Our Company is a leading global biopharmaceutical company with over 125-year history of Inventing for Life with an inspiring mission to make discoveries that positively impact global healthcare. Our success is driven by putting patients first, operating with the highest integrity, and committing fully to our vision to make a difference in the lives of people globally. With our diverse pipeline of vaccines, biologics, small molecules, and newer modalities, we are at the forefront of research to advance the prevention and treatment of diseases such as cancer, cardiometabolic diseases, Alzheimer’s disease, eye diseases, and infectious diseases including HIV, Ebola and SARS-Cov2.

Our Company's Research Laboratories’ nonclinical safety assessment group at the West Point, Pennsylvania site is seeking an experienced anatomic pathologist to join a highly collaborative team of scientists (14 anatomic pathologists, 3 clinical pathologists, and approximately 40 exceptional technical staff), working at a GLP-compliant facility with state-of-the-art anatomic, molecular and clinical pathology laboratories. Our team works on a diverse and exciting pipeline, participating in a wide variety of GLP-toxicology study types, many of which are run in-house, in addition to early discovery and investigative studies.

Pathologists at our company are integral members and leaders of collaborative cross functional scientific teams, addressing challenges from early discovery to late development. Our Company’s pathologists provide scientific leadership in the design and conduct of postmortem evaluation of studies and integrate the interpretation of postmortem data into the safety profile of drug candidates. Our Company's pathologists have diverse opportunities to learn and grow as professional scientists and drug developers through daily study related activities and collaborative works with diverse program development teams.

Key responsibilities for this scientific role include:

  • Employ both routine H&E evaluations as well as other specialized techniques to characterize the safety profile of new drugs from toxicology and investigative studies.
  • Work independently to analyze data, interpret and determine the significance of results for postmortem evaluations, review literature and design experiments to help teams solve scientific problems.
  • Serve as Program Pathologist, providing scientific input and oversight across studies from very early discovery to late-stage development, following molecules throughout their lifetime.
  • Communicate with study team/drug development teams on study findings and participate on cross-functional teams to elucidate mechanisms of toxicity and may be required to provide advanced scientific and/or technical guidance to technical and/or Ph.D/D.V.M. level staff. Utilizing additional tools and applications that are all available on-site, including:
    • An industry-leading suite of on-site in vitro and in vivo assay capabilities.
    • Access to robust historical controls slide archive and data base.
    • Transmission electron microscopy.
    • Immunohistochemistry and in situ hybridization.
    • Quantitative digital image analysis and targeted machine learning applications.
    • In vivo imaging tools (e.g., magnetic resonance imaging).
  • Develop novel biomarkers and predictive models to de-risk drug candidates for safety-related liabilities.
  • Our Company's pathologists also serve as nonclinical safety assessment leads on drug development teams, overseeing the design and execution of studies, and generation of regulatory strategy and communications with global regulatory agencies to support the development of drug candidates.
  • Our Company's pathologists work in a hybrid work environment and routinely interact with each other, share slides and opinions/experiences, and help each other learn and grow.

Required experience and skills:

  • Love to collaborate with diverse cross-functional teams and communicate openly and often with colleagues.
  • Doctor of Veterinary Medicine (DVM).
  • Residency in anatomic / toxicologic pathology.
  • ACVP or ECVP-board certification in anatomic pathology.
  • Over 5 years of experience as a pathologist in biotech, pharma or at a CRO.

Preferred experience and skills:

  • Demonstrated proficiency in histomorphology evaluation and interpretation of rodent carcinogenicity studies.
  • Strong knowledge of the drug discovery, development and regulatory processes, including experience on drug development project teams.
  • PhD in Toxicology, Pathology, or related discipline.
  • Experience in ophthalmic pathology.

Our Company has a commitment to the continued professional development of all colleagues through training opportunities, publications, internal and external presentations, access to internal scientific seminars as well as support for external scientific meetings. With our location along the Northeastern US corridor, there are many opportunities to participate in cross-industry workshops, conferences, direct regulatory interactions and other training or networking opportunities. Imagine what you could achieve at our Company

Employee Status: Regular

Relocation: Domestic/International

VISA Sponsorship: Yes

Travel Requirements: 10%

Flexible Work Arrangements: Hybrid

Shift: 1st - Day

Valid Driving License: No

Hazardous Material(s): N/A

Job Posting End Date: 12/14/2024

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