PRINCIPAL/SENIOR SCIENTIST, DISCOVERY

3 weeks ago


CA United States Lexeo Therapeutics Full time
About Lexeo

Lexeo Therapeutics is a New York City-based, clinical-stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer's disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer's disease programs.

Primary Responsibilities
  • Lead and contribute to the design, execution, and interpretation of experiments to validate novel drug targets.
  • Oversee design and screening of new AAV constructs for discovery
  • Develop and optimize assays and screening strategies to characterize lead gene therapy candidates.
  • Collaborate with cross-functional teams to advance drug discovery and development projects.
  • Analyze and interpret data from in vitro and in vivo pharmacology &safety studies.
  • Research latest scientific trends and technological advances in gene therapy.
  • Design and oversee preclinical studies to evaluate the efficacy and safety of candidate therapeutics.
  • Contribute to the preparation of regulatory documents, including IND submissions.
  • Mentor and supervise junior scientists in a cross-functional setting.
  • Present research findings at internal meetings, scientific conferences, and in peer-reviewed publications.

Required Skills & Qualifications
  • Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field.
  • 5+ years of post-Ph.D. experience in a biotech/pharma setting, with a focus on gene therapy research.
  • Drug Discovery for gene therapy or nucleic acid medicines
  • Familiar with AAV gene therapy design and development
  • CRO management for conducting in vivo research studies
  • Designing in vivo gene therapy studies and dosing
  • Experience in biodistribution studies and pharmacology related to gene therapy applications.
  • Gene therapy assay development
  • Designing IND-enabling studies is a plus.
  • Deep understanding of molecular biology techniques (RNA/DNA isolation, ddPCR, RNAscope, western blot)
  • AAV vector design, titering, dosing
  • Expertise in in vivo models for biodistribution and pharmacology studies.
  • Strong analytical skills and proficiency in statistical data analysis.
  • Excellent communication and project management abilities.
  • Graphpad, excel etc.

Anticipated Salary Range
Depending on qualifications and overall experience, base salary is likely to $150,000 - $190,000 per year.

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.
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