POSTDOCTORAL POSITION – Advanced Immunotherapies of Rejection and Autoimmunity
3 weeks ago
A Postdoctoral position is available for a determined, people-smart, and driven PhD graduate with a solid training in immunology (additional background in bioinformatic, material science, or genetics is a welcomed plus) to contribute to the development of next gen immunotherapies for transplant rejection at Johns Hopkins University.
The VCA Lab () is a multi-disciplinary research laboratory standing on the pillars of transplant immunology and immunoregulation, regenerative medicine, cryopreservation, and nerve research. In the Transplant Immunology team, we focus on understanding novel mechanisms of T lymphocytes activation and regulation as well as deciphering the complex interactions with their environment during rejection and autoimmunity. We then use this knowledge to develop novel immunotherapeutic strategies. We are seeking candidates to contribute, under the guidance of Dr. Giorgio Raimondi, to two arms of research. In our well-established multidisciplinary collaboration to engineer drug delivery strategies of targeted regulation of pathogenic T cells, the postdoc will help unraveling novel mechanisms of innate signaling that contribute to the activation of anti-graft T cells and will define novel targets of intervention. The second area of research is centered on investigating the effect of engineering the composition and function of thymic epithelial cells (key to the development of T cells), with the goal of altering the development of graft-reactive T cells and promoting transplant acceptance and protection. In true “integrated immunology” fashion, the candidate will implement cutting edge techniques including genetic engineering, fate-mapping, high-parameters screenings, omics approaches, whole tissue clearing and 3D imaging, to make fundamental new contributions and define bold new principles of therapeutic intervention. Moreover, thanks to our group extensive micro-surgical expertise, the efficacy of newly devised immunotherapies will be promptly assessed in rodent transplant models.
Qualifications
- Requires a recent Ph.D. in Immunology or closely related field;
- Research experience in the area of basic immunology - transplantation immunology or autoimmunity is highly desirable;
- Ability to design and carry out in vitro and in vivo experiments using mouse models;
- Experienced in high parameter flow cytometry and other techniques like transcriptomic analysis, immunofluorescence microscopy, and basic molecular biology techniques;
- Ability to work independently, collaboratively, and with excellent verbal and written communication skills.
Interested candidates should email their CV and a brief statement of how their research experience aligns to our focus to VCALab@jh.edu
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