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Senior Clinical Research Associate

1 month ago

Seattle, United States Aequor Full time

*Job Title: Senior Research Associate

*Location: Seattle-Dexter, WA * Hybrid - The GDEPD department adheres to an 80% onsite requirement for all lab-based employees. This gives employees the flexibility to work at home 1 day per week.


*Top Skills:

• Process Development Experience is required

• Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing

• Experience with upstream processes intensification e.g. fed-batch and perfusion development, process-analytical technology (PAT)

• Experience with suspension culture of mammalian cells in shake flasks and small stirred tank bioreactors

• Experience with transfection-based processes

• This position is a highly technical lab-based role. The right candidate will have recent experience in a similar role (Not manufacturing or leading teams)


The associate will join the LVV Platform Development team working on vector biology and molecular optimization initiatives intended to drive next-generation viral vector platform development. Specifically, in the pursuit of end-to-end assessment of novel technologies and approaches, the associate will seek to become highly proficient in upstream production and downstream purification of lentiviral vectors, while gaining familiarity with LVV analytical methods and their interpretation in the context of LVV attributes and biology. The associate will also have the unique opportunity to be exposed to a wide range of highly novel molecular designs, and to work collaboratively with a range of different groups doing different types of LVV development.


Responsibilities:

• Material generation of LVV for downstream processing

• Execute and troubleshoot upstream and downstream process development experiments supporting next-generation LVV production

• Manage the flow of samples and data and perform analyses

• Assist in the design of experiments and interpretation of data

• Provide experimental design and execution support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.)

• Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities

• Actively participate and support lab maintenance and continuous improvement initiatives

• Maintain accurate and detailed laboratory notebook and documentation

• Summarize and present data in group meetings and contribute to group discussions and team strategy

• Author technical reports and study memos


Basic Qualifications:

• STEM degree with 2+ years of relevant industry experience; title/compensation will ultimately be commensurate with education, experience, and skillset

• Experience with suspension culture of mammalian cells in shake flasks and small stirred tank bioreactors

• Hands-on experience in process development

• Independently motivated with the ability to work in teams

• Ability to communicate clearly and concisely through oral presentation and technical writing

• Ability to leverage literature, and internal and external resources to solve problems


Preferred Qualifications:

• Degree in biological or chemical engineering, biochemistry, or bio-related field

• Experience with JMP for DoE design and analysis

• Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing

• Experience with DSP operations

• Experience with upstream LVV optimization

• Experience with transfection-based processes

• Experience with upstream processes intensification e.g. fed-batch and perfusion development, process-analytical technology (PAT)

• Experience with single-use technologies


Additional Job Requirements:

Position Handles Hazardous Materials