Principal Scientist/ Associate Director, PBPK Modeling

1 month ago

Philadelphia, United States SciPro Full time

SciPro has partnered with a global biopharma organization with a goal to bring science, technology, and talent together to address disease and positively impact the health of in need populations. They are committed to create an environment where our employees can thrive while preventing and treat disease, they aspire to improve the health of 2.5 billion individuals worldwide within the next decade.



This organization is hiring for an Associate Director of Biopharmaceutics that will work on a matrixed team with DMPK, Clinical Pharmacology, Safety, CMC and contribute to the strategic growth of this companies pipeline. If you would like to join an organization where you can strive to create an inspiring and challenging workplace to be your best self, feel included and valued, grow professionally, and prioritize your wellbeing.


What you will be doing and requirements:

  • A PhD with at least 5 years of experience in biopharmaceutics, drug absorption/pharmacokinetics, PBPK modeling, in-silico platforms, and/or drug delivery for small molecules and/or biologics.
  • Experience in biopharmaceutics/drug absorption, related tools (in-vivo, in-vitro, in-silico), and product design and development.
  • Proficiency in mechanistic PBPK modeling using Gastroplus or Simcyp and using in-silico platforms like MATLAB and application to product design across various dosage forms (e.g., oral, long-acting injectable, implants, and biologics).
  • Experience in in-vitro biorelevant measurements, such as solubility/dissolution, IDR, transfer models for oral biopharmaceutics, in-vitro release methods for long-acting injectables and implants, SCISSOR model for subcutaneous modality.
  • Familiarity with regulatory biopharmaceutics requirements and drug development processes.


In addition to these required skills, the following characteristics are preferred:

  • Respected by peers and considered an expert in their scientific field or technical area.
  • General knowledge of preclinical and clinical development disciplines, including DMPK, safety, and clinical pharmacology, and ability to integrate biopharmaceutics/modeling with formulation design across dosage forms.
  • Experience working in a matrix environment and collaborating across functions/disciplines.
  • Understanding of late-stage product development and regulatory requirements for change management in a global context.
  • In-depth knowledge of the literature in their scientific discipline and/or biopharmaceutics.
  • Experience in formulation design across various dosage forms.


If this role suits your background, reach out by applying through LinkedIn.

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