Research Associate in Chemistry

6 months ago

Charlottesville, United States Commonwealth of Virginia Full time
The Department of Chemistry at the University of Virginia invites applications for a Postdoctoral Researcher position to work in the lab of Marcos Pires, Associate Professor.

The Pires research group has recently demonstrated that several cell wall biosynthetic enzymes display broad substrate promiscuity. Their research team has pioneered a novel strategy to graft haptens onto bacterial surfaces to recruit endogenous antibodies with the ultimate goal of enlisting the immune system to clear bacterial infections. Moving forward, the Pires laboratory will develop a transformative class of cell wall probes that reveal key features of cell wall sensing and remodeling dynamics in live cells. Their advances in this area demonstrate that their research team can be highly competitive as they expand their methodologies to elucidate how bacterial cell walls are detected by the human immune system and how cell wall structural modifications control bacterial drug resistant phenotypes.

The Postdoctoral Researcher will work as part of a team of scientists to design and synthesize small molecules, peptides, or express proteins that label live bacterial cells. The focus is primarily on synthetic components and analysis in bacterial cells. Research duties will include protein expression and purification from bacteria and subsequent modification (bioconjugation) and peptide synthesis in solution phase and/or solid phase. Responsibilities may include bacterial cell-based assay development and optimization, elucidation of biologically relevant targets/mechanisms of action, flow cytometry analysis, and confocal microscopy. Postdoctoral Researchers will publish their findings in high impact, peer-reviewed journals and be co-inventors on patents related to their work. Of particular interest at this time is experience with animal experiments and microbiology.

QUALIFICATIONS: A Ph.D. degree in Chemistry, Biochemistry, or Pharmaceutical Sciences, or a related discipline is required by the appointment start date. Also list any skills and/or experience levels to help with the selection process

APPLICATION PROCEDURE: Apply online at and attach a maximum one-page cover letter, a curriculum vitae, maximum three-page statement of their research interests, experience, and plans, and the contact information for three individuals who can provide professional reference letters.

Please note that multiple documents can be uploaded in the box .

APPLICATION DEADLINE: Review of applications will begin right away and the position will remain open until filled. Starting date is flexible, but the anticipated start date is summer of 2024. The University will perform background checks on all new hires prior to employment.

This is a one-year appointment; however, the appointment may be renewed for additional one-year increments, contingent upon available funding and satisfactory performance.

For questions regarding this position, please contact Marcos Pires, Associate Professor, at

For questions about the application process, please contact Rich Haverstrom, Faculty Search Advisor, at

For more information on the benefits available to postdoctoral associates at UVA, visit postdoc.virginia.edu and hr.virginia.edu/benefits .

The University of Virginia, i ncluding the UVA Health System which represents the UVA Medical Center, Schools of Medicine and Nursing, UVA Physician’s Group and the Claude Moore Health Sciences Library, are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity or expression, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.

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