Senior Scientist, Translational Science

4 weeks ago

Remote, Oregon, United States Spyre Therapeutics Full time

Spyre Therapeutics (NASDAQ: SYRE) is a biotechnology company aiming to address the needs of the millions of people living with inflammatory bowel disease (IBD) by advancing potentially best-in-class long-acting antibodies, rational therapeutic combinations, and precision immunology approaches. Spyre is advancing a robust portfolio that harnesses both proven and novel mechanisms of action for addressing IBD. The company's two parallel lead programs—SPY001 and SPY002—target ɑ4β7 and TL1A, respectively, and build upon the validation of these targets by existing commercial- and clinical-stage antibody therapeutics. The company's lead programs are projected to enter clinical studies in 2024.


Role Summary:

We are seeking a highly skilled and motivated Senior Scientist to join our growing team at Spyre. This function will utilize biomarkers to help identify populations more likely to respond to Spyre's drug candidates, establish evidence of drug exposure and target engagement, and assess response, with an emphasis on the molecular impacts of combination therapy. The Senior Scientist will be responsible for multiple biomarker aspects including oversight of biomarker assay development and validation at external vendors, biomarker lab manual development, biomarker sample management, biomarker data generation and analysis across Spyre's pipeline and may serve as the biomarker lead on certain development programs. This individual will be a key member of the team driving execution of Spyre's translational strategies to support the development of Spyre therapeutic antibodies. Substantial effort will be spent directing biomarker assay development and validation at CROs and generating clinical biomarker sample analysis and data analysis in a variety of written reports or other documents. This role will report to the Sr. Director & Head of Translational Science and interact with multiple other functional teams within Spyre (Clinical, Clinical Operations, Nonclinical, Quality, Project Management, Regulatory, etc.)

Key Responsibilities:


• Contribute to the design, development, validation, operationalization, and execution of clinical biomarker assays in accordance with relevant regulatory requirements including review of literature and assessment of compliance, when appropriate.

• Recommend and oversee CROs executing all biomarker analysis related to target engagement, mechanism of action, pharmacodynamics. Experience with bioanalysis is a plus.

• Travel to and scientifically evaluate vendors/CROs for the purpose of conducting a variety of studies related to biomarker activities.

• Communicate plans, progress, and results of key studies to internal and external audiences via written and verbal means.

• Work closely with project management, biostatisticians, data scientists, and outside consultants, and other stakeholders to ensure delivery of high-quality biomarker data.

• Deliver high-quality biomarker data packages as required for successful regulatory approval and commercialization.

• Serve as Translational Science representative on a multidisciplinary team of R&D professionals to progress therapeutic molecules in the clinic.

Ideal Candidate:


• PhD or equivalent experience in relevant discipline (e.g., pharmacology, immunology, or another relevant field)

• 4+ years of translational science and/or drug development experience with complex biologics spanning early development.

• Experience with different biomarker assay platforms: flow cytometry, ligand-based assays, transcriptomics etc.

• Experience with CRO engagement and oversight a plus.

• Excellent communication skills with an ability to present to a variety of stakeholders and adjust message for maximum understanding of all parties.

• Strong leadership mentality, willing to learn from others, and dedication to being an excellent colleague within Spyre and with our key partners.

• Detail-oriented, with good organizational, prioritization, and time management skills.

• Ability to multi-task and keep pace with a fast-moving organization.

• Ability and willingness to travel at least quarterly in support of team objectives and goals.

What We Offer:

  • Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
  • Unlimited PTO
  • Two, one-week company-wide shutdowns each
  • Commitment to provide professional development opportunities.
  • Remote working environment with frequent in-person meetings to address complex problems and build relationships.

The expected salary range offer for this role is $133,000 to $159,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location.


As an equal opportunity employer, Spyre is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients.

Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain "" We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email.

Please also be aware that all job postings will be listed on our website at

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