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Scientist, Discovery Biology

3 months ago


Arvada, Colorado, United States Merck Full time

Job Description

We are seeking a dedicated and highly motivated Scientist to join the Vaccine Platforms group in the Infectious Disease and Vaccines department at our company in West Point, PA. The main objective of our group is to discover and develop novel RNA-based vaccines. Toward this goal, we are seeking an individual with the knowledge and technical skills in molecular biology to design and prepare RNA constructs for high-throughput screening, in vitro assays and to support downstream in vivo studies. This role requires both prior experience and the desire to learn and develop as a scientist. We also value the ability to effectively contribute scientific ideas, participate in team discussions, maintain an organized and efficient lab space, and collaborate within a dynamic team to foster a healthy work environment. The successful candidate will work at the cutting-edge of vaccine discovery, which utilizes state-of-the-art instrumentation, automated robotic workflows, and artificial intelligence to ease suffering worldwide.

Qualifications:

  • B.A./B.S. in Biology, Molecular Biology, Immunology, Chemistry, Biochemistry, or related discipline with a minimum of 2 years of experience in an academic or industry lab
  • M.S. in Biology, Molecular Biology, Immunology, Chemistry, Biochemistry, or related discipline (with expected graduation by November 2024)
  • Proficiency of basic scientific principles and molecular biology including plasmid design, cloning, and site-directed mutagenesis.
  • Experience with standard molecular biology techniques (e.g. gel and capillary electrophoresis, binding assays, ELISA, RT-qPCR, chromatography, etc).
  • Able to maintain organized workspace and properly document experiments in an electronic notebook.
  • Excellent interpersonal skills, both written and oral.
  • Self-starter with ability to work independently and multitask in a fast-paced environment.

Preferred:

  • Experience with RNA design, in vitro transcription and purification is preferred.
  • Experience with FPLC/HPLC chromatography (AKTA system) is preferred.
  • Experience with mammalian cell culture is preferred.

Responsibilities:

  • Molecular cloning
  • Design and prepare mRNA constructs for high-throughput screening.
  • Scale-up preparation of high-quality mRNAs for in vivo study.
  • Develop assays and perform quality assessments for mRNA production.
  • Collaborate closely and effectively with scientists on the team to understand project requirements. Properly document and effectively communicate results.
  • Design experiments, interpret and track results, and utilize findings for assay development and optimization.
  • Maintain accurate lab records and inventory management.
  • Effectively utilize available databases for sample tracking and data/results management.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separationpackage, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

No relocation

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

N/A

Job Posting End Date:

07/12/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date:07/12/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R301334