Associate Director

4 weeks ago


San Diego, California, United States Escient Pharmaceuticals Full time

The Senior Scientist, Translational Biology and Drug Discovery leads and contributes to the implementation and analysis of translational biology, in vitro and in vivo pharmacology for validation of multiple targets.Leads and supports the team to generate and test novel experimental hypotheses to advance discovery-based research and development in mast cell diseases by performing and overseeing various in vitro, in vivo and ex vivo assays as well as other methodsPhD in physiology, molecular biology, immunology, neuroscience or relevant biological disciplineExperience with translational in vitro and ex vivo functional assays using, primary cells, human and rodent tissue samples and human matrices with readouts such as multi-parametric flow cytometry, multiplex ELISA, and application of these techniques to pharmacological studiesExperience in basic rodent handling, oral gavage, intraperitoneal injection, blood collection, and euthanasia; Conduct various IACUC approved laboratory animal procedures and techniquesExperience with in vivo development of models of inflammation, autoimmune and pain with an emphasis on disease modeling for visceral, migraine, and other inflammatory disorders is a plusDesire to perform hands-on in vivo and in vitro biological experiments in a fast-paced research and development environmentProficient in laboratory bench skills such as Tissue culture, ELISAs, Western blots, qPCR, Flow cytometry, and histology



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