Senior Research Associate, Stem Cells
3 months ago
Senior Research Associate, Cellular Reprogramming
Manchester, NH
Our client is a leader in treatments for pulmonary arterial hypertension and other life-threatening diseases. They are looking for a Senior Research Associate, Cellular Reprogramming who will perform cell studies and execute analytical methods to support the production and process development of autologous reprogramming of somatic cells.
Responsibilities:
- Perform and optimize the development of a robust, autologous reprogramming process from circulating cell types
- Design studies and lead efforts to propagate and characterize newly generated iPSC lines
- Write and update SOPs and batch records for various reprogramming processes
- Write and update standard operating procedures for operation and maintenance of laboratory equipment
- Conduct the technical transfer of assays into the production team or to internal manufacturing, as needed
- Design cell studies to address technical and scientific challenges to derivation of iPSCs from blood
- Record and manage use of materials and reagents needed to carry out experiments
- Meet 1:1 with managers to review results and progress
- Maintain smooth operations of the lab, including maintenance of lab supplies, monitoring of equipment, providing general lab support, and helping identify areas for improvement
- Follow proper procedures regarding laboratory safety, use of personal protective equipment, and handling of biohazard materials, including human or animal cells and tissues
- Record all laboratory data in the in-house data management system(s)
- Mentor and train junior staff in laboratory processes and procedures as needed
- Perform other duties as assigned
Minimum Requirements
- Bachelor’s Degree in cellular biology, developmental biology, biomedical engineering or related field with 5+ years of experience in a cell biology, developmental biology or biomedical engineering environment with a bachelor's degree or 3+ years of experience in a Cell Biology, Developmental Biology or Biomedical Engineering environment with a master's degree
- Aseptic Technique and mammalian cell culture
- Experience with IPSC culture and/or maintenance
- Knowledge of cell biology
- Flow Cytometry
Preferred Qualifications
- Master’s Degree in cellular biology, developmental biology, biomedical engineering or related field
- Technical expertise in iPSC reprogramming and maintenance of iPS cultures
- Technical expertise in maintenance of iPS cultures
- Ability to initiate and manage day-to-day tasks effectively, including multi-tasking, flexibility and adaptability
- Ability to independently follow experimental methods and protocols
- Comfortable working in a hands-on laboratory environment and have good attention to detail and good lab practices
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