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Analytical Chemist

2 months ago

Cambridge, United States Integrated Resources, Inc ( IRI ) Full time

Job Summary:

Seeking an exceptional candidate to contribute to pre formulation research in a small, fast-paced and highly collaborative team. This contract position resides within the Formulations Sciences group of Pharmaceutical Sciences. The candidate will work full time onsite and contribute to the execution of laboratory activities related to the transition of Client small molecule compounds from Discovery into Development in support of pre-clinical and clinical programs. An ideal candidate will have a strong foundation in analytical techniques such as UPLC/HPLC (Empower proficiency) and an understanding of early drug development processes and experiments. Experience in pre formulation development and physicochemical characterization is highly desired, however not required.

An ideal candidate would have approximately 2+ years’ experience working in pharmaceutical sciences (pre formulation, analytical or formulation development).

Responsibilities:

Prepare buffers and common lab solutions

Execution of analytical experiments with XRPD, DSC, TGA, DVS, SEM, optical microscopy and UPLC/HPLC (Empower)

Screen excipients/formulation vehicles for solubility and stability to optimize preclinical formulations to enable non-GLP and GLP pre-clinical studies

Perform drug substance and formulation stability studies to ensure optimal formulation design

Coordinate vehicle/formulation preparations for in vivo studies

Execute dissolution studies (Distek and Pion µDISS) to support formulation development and FIH development

Maintain an accurate, timely, and compliant laboratory notebook

Qualifications:

B.S. degree in chemistry, analytical chemistry, pharmaceutics, chemical engineering or material sciences

2+ years’ experience working in pharmaceutical sciences (pre formulation, analytical or formulation development)

Experience in the Discovery and Development interface [desirable not required]

Experience working with common excipients and volumetric glassware

Proficiency with UPLC/HPLC and Empower Software

Some knowledge of and interest in learning more about small molecule and pre-clinical formulation development

Capabilities:

Ability to effectively prioritize and manage multiple tasks and compounds

Self-motivated and willing to “learn on the job” and ask for assistance when needed

At home in a results-driven, highly accountable environment where you can make a clear impact

A team player, who listens effectively and invites response and discussion

A collaborator who communicates in an open, clear, complete, timely and consistent manner

All applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

Certifications & Licenses:

Proficiency with UPLC/HPLC and Empower Software