Senior Scientist, Protein Conjugation
4 weeks ago
About Us:
Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.
Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms, Fable has recently initiated its internal therapeutic pipeline and has enacted a growing list of pharma research collaborations.
Backed by a 2024 $40M Series A investment co-led by Versant Ventures and DCVC, Fable is positioned to lead in the purposeful integration of biology and computation to solve complex medical challenges. Fable’s aspiration is to write the next chapter of what protein-based therapeutics can do.
Description:
We are seeking a highly talented and motivated scientist to join our growing team and establish our in-house protein conjugation capabilities. As an expert in biologics drug discovery, you will be primarily responsible for conjugation of antibodies and other protein-based candidate therapeutics from our bespoke AI designed libraries using a variety of chemistries and payloads. You will have the opportunity to contribute to design the ideal lab environment to support your protein conjugation workflows, including analytics and robotics/automation. The data you generate will be used to explore new concepts and to design potent therapeutic candidates.
As a senior lab member reporting directly to the Head of Discovery Biologics, you will help mentor and train more junior scientists. You will also have the opportunity to serve as a functional expert on our therapeutic Pipeline Project Teams, and develop your drug hunting skills and experience.
In order to execute on accountabilities, an on-premise working model is expected. Flexible working hours to promote a balance between productivity and wellness can be accommodated with manager approval.
Responsibilities:
- Design and evaluation of different linker/payload structures and methods of protein conjugation
- Generation of antibody and other protein conjugates using a variety of chemistries and payloads, with opportunity to design and build the lab
- Characterization of the protein conjugates in robust bioanalytical and in vitro assays
- Use of liquid handlers and automation for high-throughput methods
- Binding assays based on SPR, BLI and ELISA
- Careful documentation and record-keeping of scientific results
- Upload of data to databases and LIMS systems
- Curation of data for ingestion and utilization by ML scientists
- Mentoring and training of junior scientists
About You:
- PhD/postdoc in Protein Engineering, Bioengineering, Protein Chemistry or similar field and 4+ years industry experience in biologics discovery and protein science OR MSc and 6+ years experience
- Proven track record in Antibody Drug Conjugates (ADCs) and other protein conjugation technologies
- Experience using various analytical instruments and methods (aSEC, aHIC, DSC, DSF, Mass Spectrometry, etc.) for the biophysical characterization of protein conjugates
- Familiarity with liquid-handling and high-throughput systems
- Committed to digital workflows and the lab of the future
- Ability to work efficiently in a close-knit team and deliver high quality, reproducible data in a fast-paced environment
- Attentive to detail and a careful experimentation
- Ability to take initiative and improve processes
- An excellent communicator and presenter of scientific data
- Passionate about the power of AI to transform biotherapeutics
- Focused on quantifiable results and data driven decisions
- Collaborative and inclusive mindset
At Fable Therapeutics, we know that our people drive our success. We are an equal opportunity employer and we value diversity and inclusion. Fable Therapeutics provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Fable Therapeutics does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law.
For accommodations during the interview process please email hr@fabletx.com
-
Senior Scientist, Protein Conjugation
1 week ago
cambridge, United States Fable Therapeutics Full timeAbout Us: Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and...
-
Senior Scientist, Protein Conjugation
4 weeks ago
Cambridge, United States Fable Therapeutics Full timeAbout Us: Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and...
-
Senior Scientist, Protein Conjugation Expert
1 week ago
Cambridge, Massachusetts, United States Fable Therapeutics Full timeAbout UsFable Therapeutics is a biotechnology company that develops innovative biologics designed to overcome therapeutic index limitations. Our team is powered by state-of-the-art structure and sequence-based protein language models.We are seeking a highly skilled Senior Scientist to join our team and establish our in-house protein conjugation capabilities....
-
Senior Scientist, Protein Conjugation Expert
2 weeks ago
Cambridge, Massachusetts, United States Fable Therapeutics Full timeAbout Fable TherapeuticsFable Therapeutics is a pioneering biotechnology company dedicated to harnessing the power of AI-driven biologics to revolutionize protein-based therapeutics. Our mission is to push the boundaries of what is possible in the field of biologics discovery and development.Job SummaryWe are seeking a highly skilled and experienced Senior...
-
Senior Scientist, Protein Conjugation Expert
4 days ago
Cambridge, Massachusetts, United States Fable Therapeutics Full timeAbout Fable Therapeutics:We are a discovery-stage biotechnology company that develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.Our company is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and...
-
Senior Scientist, Protein Conjugation Expert
4 weeks ago
Cambridge, Massachusetts, United States Fable Therapeutics Full timeAbout Fable TherapeuticsWe are a discovery-stage biotechnology company that develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.Our team is powered by state-of-the-art structure and sequence-based protein language models, and we are backed by a 2024 $40M Series A...
-
Cambridge, United States UCB Full time Make your mark for patients To strengthen our Discovery Sciences and Protein Sciences teams in our Boston hub in Cambridge, MA, USA, we are looking for a talented individual to fill the position of: Scientist or Senior Scientist. As (Senior) Scientist, you will contribute to a scientific team as protein biochemist and cellular biologist. You...
-
Cambridge, Massachusetts, United States Planet Pharma Full timeJob Title: Principal Scientist, Protein ProductionPlanet Pharma is seeking a highly skilled Principal Scientist, Protein Production to join our team in Cambridge, MA. As a key member of our research team, you will be responsible for leading the development and optimization of upstream and downstream processes for protein production.Key...
-
Principal Scientist, Protein Sciences
4 days ago
Cambridge, Massachusetts, United States Flagship Ventures Full timeRole SummaryFlagship Ventures is seeking a dedicated and skilled Principal Scientist, Protein Sciences to join our team. The role will focus on peptide or antibody production, discovery, and engineering through hit optimization and lead identification.Key ResponsibilitiesLead and manage projects focused on peptide or antibody production, discovery, and...
-
Principal Scientist, Protein Sciences
1 month ago
Cambridge, Massachusetts, United States Flagship Ventures Full timeCompany OverviewFlagship Ventures is a pioneering technology company that leverages artificial intelligence to transform the scientific method. As a privately held, early-stage company, we are backed by Flagship Pioneering, which provides the resources and vision needed to achieve groundbreaking results.Job SummaryWe are seeking a highly skilled Principal...
-
Principal Scientist, Protein Production
4 weeks ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
-
Principal Scientist, Protein Production
3 months ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
-
Principal Scientist, Protein Production
3 months ago
Cambridge, United States Planet Pharma Full time613284Our client, a leading Biotechnology company in Cambridge, MA , is looking for a Principal Scientist, Protein Production & Process Development with experience producing protein lead and Development Candidate molecules, preferably with both mammalian and E. coli production processes. The Principal Scientist will engage a diverse team of research...
-
Scientist, Bioconjugation Chemistry
2 months ago
Cambridge, United States Intellia Therapeutics Full timeWhy Join Intellia?Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to...
-
Senior Research Scientist
1 week ago
Cambridge, Massachusetts, United States Incendia Therapeutics Inc Full timeJob Title: Senior Research ScientistJob Summary:Incendia Therapeutics Inc is seeking a highly motivated Senior Research Scientist to join the Biotherapeutics Drug Discovery group. The successful applicant will support therapeutic antibody discovery and optimization campaigns, including leading reagent generation strategies, developing antibody campaign...
-
Senior/Principal Scientist, Biology
1 week ago
Cambridge, Massachusetts, United States Crossbow Therapeutics, Inc Full timeCrossbow Therapeutics, Inc. is a biotechnology company dedicated to improving the lives of people with cancer by unlocking the therapeutic potential of T-cell receptor (TCR)-mimetic antibodies. Our T-BoltTM therapies are next-generation, easily assembled immunotherapies directed with high precision at previously unreachable cancer cell targets. Our approach...
-
Senior Research Scientist
1 week ago
Cambridge, Massachusetts, United States Synectics Inc Full timeJob SummaryWe are seeking a highly skilled and motivated scientist to join our Immunology Discovery department in Cambridge, MA. The successful candidate will be responsible for developing therapeutic molecules using recombinant DNA technology, expression, and purification of recombinant proteins, as well as testing purified proteins in functional cellular...
-
Senior Research Scientist, RNA Chemistry
2 months ago
Cambridge, Massachusetts, United States Sarepta Therapeutics Full timeAbout the RoleWe are seeking a highly skilled and experienced Senior Research Scientist to join our RNA Chemistry team at Sarepta Therapeutics. As a key member of our team, you will be responsible for designing and conducting novel oligonucleotide conjugates synthesis, purification, and characterization. You will also apply state-of-the-art delivery methods...
-
Cambridge, Massachusetts, United States Skills Alliance Full timeJob SummaryWe are seeking a highly motivated and passionate research associate to support drug discovery projects. The successful candidate will have a solid understanding of protein biochemistry and molecular biology, with experience in structural biology being advantageous.Key Responsibilities:Develop and execute strategies to clone and express recombinant...
-
Scientist
2 weeks ago
Cambridge, United States Randstad Life Sciences US Full timeScientist I6 MonthsCambridge, MA Job description:We are currently seeking a highly motivated and passionate scientist in cellular immunology to join our team in Immunology Discovery department based in Cambridge MA.The candidate will focus on making therapeutic molecules using recombinant DNA technology, expression/purification of recombinant proteins,...
