Senior Research Associate

3 months ago

Gaithersburg, United States MESO SCALE DIAGNOSTICS, LLC. Full time

POSITION SUMMARY:

The Senior Research Associate in Protein Biochemistry is responsible for contributing to the development and characterization of proteins for therapeutic and diagnostic applications.


DUTIES AND RESPONSIBILITIES:

• Express recombinant proteins using various systems (e.g., bacterial, mammalian, insect).

• Purify proteins using chromatographic techniques (e.g., affinity, ion exchange, size exclusion).

• Perform biochemical and biophysical assays to assess purified proteins for quality, purity, and activity (e.g., SDS-PAGE, Western blotting, ELISA, UV/Vis spectroscopy).

• Analyze experimental data and present findings to the team.

• Maintain accurate and detailed laboratory records, including experimental procedures, results, and conclusions.

• Contribute to the preparation of technical reports, presentations, and scientific publications.

• Participate in project meetings and contribute to the design and planning of experiments.

• Communicate effectively with team members and external collaborators.


EXPERIENCE AND QUALIFICATIONS:

• Bachelor’s in Biochemistry, Molecular Biology, Biotechnology, or a related field.

o Master’s degree is preferred.

• A minimum of two years of hands-on laboratory experience in protein biochemistry required

o Academic or industry experience preferred.


KNOWLEDGE, SKILLS AND ABILITIES:

• Proficiency in protein expression systems (e.g., E. coli, HEK293, Sf9).

• Experience with chromatographic purification techniques and equipment (e.g., ÄKTA systems).

• Familiarity with protein characterization methods (e.g., mass spectrometry, CD spectroscopy, DSC).

• Familiarity with methods for characterization of protein-protein interaction (e.g. SPR, BLI, ELISA)

• Strong analytical and problem-solving abilities.

• Demonstrated aptitude for learning of and adhering to standard laboratory techniques and safety precautions.

• Solid communication (written and verbal) skills regardless of the format (e.g., documents, public speaking situations, presentations, etc.).

• Excellent organizational, planning, and time management skills with the ability to manage multiple and often changing priorities and issues of varying complexity, while meeting time-sensitive deadlines and deliverables.

• Attention to detail with demonstrated commitment to excellence and performance.

• Demonstrated propensity to be creative, collaborative, proactive, and self-motivated in the execution and completion of assigned tasks.

• Ability to work both independently and as an effective team member.

• Ability to execute complex experiments with limited guidance.

• Ability to identify issues and troubleshoot solutions.

• Solid data analysis skills. Sound knowledge of MS Excel. Knowledge of GraphPad Prism and SharePoint a plus. Basic knowledge of statistics.


PHYSICAL DEMANDS:

• While performing the duties of this job, the individual is frequently required to sit and stand for long periods. The individual is occasionally required to walk; use hands and fingers to operate, handle, or feel objects, tools, or controls; reach with hands and arms.

• Up to 75% of the day may be spent at a lab bench.

• There are aspects of the position’s duties that require a person in this role to work at heights above four (4) feet on occasion and move/lift up to 25 pounds.


WORK ENVIRONMENT:

• Laboratory environment working with chemical reagents and performing some Biosafety Level 2 work.

o May involve handling of BSL-2 materials and organisms including human blood and/or blood products.

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