Scientist
1 month ago
Job Summary
We are seeking a dynamic scientist who has extensive experience in the analysis of oligonucleotides to support pipeline production and characterization of oligonucleotides. The successful candidate will be responsible for characterizing siRNA and other nucleic acid structural forms with multiple analytical techniques, including liquid chromatography and high-resolution mass spectrometry (HR MS). The individual will focus on developing and executing LC-MS-based assays to support lead finding/optimization efforts. In addition, the candidate will function as part of a multi-disciplinary project team that will coordinate with scientists in cross functional areas to advance the lead molecules. In addition, this scientist will collaborate with a cross-functional team of experts to focus on the development and optimization of CASi candidates, as well as supervising and supporting junior team members.
Responsibilities
• Develop and optimize methods to fully characterize oligonucleotide drug substance and drug product materials, including HPLC, LCMS, ICP-MS, and all other relevant technologies.
• Oversee and execute the characterization of oligonucleotide materials from discovery and research stage through to development-stage compounds.
• Collaborate with internal and external manufacturing partners to develop robust analytical methods.
• Report at project team meetings, write analytical development reports, provide recommendations to management.
• Manage and support junior team members and assist with recruiting efforts as needed.
• Participate in multidisciplinary teams including Biology (in vitro and in vivo pharmacology), and Chemistry (production, analytical sciences, and platform chemistry groups)
• Provide periodic updates of efforts and results to senior management
• Deliver innovative solutions using a diversity of thought and experiences.
• Ensure the quality of each delivered entity.
• Document all experimental activities and results in lab notebooks, report data with analysis of results in presentations and/or written reports to the scientific team.
Required Qualifications:
• Scientist - PhD in analytical, organic chemistry or a related discipline with a minimum of 1 year of direct experience in oligonucleotide analysis
• Previous experience with oligonucleotide analytical methods within the biotechnology or pharmaceutical industry setting is strongly preferred.
• Strong method development skills including experience with HPLC/UPLC platforms, capillary electrophoresis and mass spectrometry techniques is required
• Previous experience with Orbitrap platform strongly preferred
• Proficiency with Chromeleon, Xcalibur and Biopharma Finder is preferred.
• Previous experience managing project teams or direct reports within a biotechnology organization is preferred.
• A history of authoring publications and/or study reports.
• A deep commitment to working as part of teams to deliver breakthrough medicines.
• Excellent communication, organization, and time management skills and ability to work both independently and collaboratively.
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