Scientist I/II, Chemoproteomics

4 weeks ago

San Diego, United States Light Horse Therapeutics Full time

Light Horse Therapeutics is a small molecule drug discovery company based in San Diego, employing tools from chemical and computational biology, in conjunction with precision genome editing methods to identify functional/ ligandable sites on high value oncology protein targets for therapeutic intervention. Light Horse therapeutics was founded by leading academics Brian Liau (Harvard), Ben Cravatt (Scripps) and Nathanael Gray (Stanford) with initial financial backing from Versant Ventures and Mubadala Capital.


Light Horse Therapeutics is seeking a talented, motivated and creative scientist to join the Chemoproteomics group. Reporting to the Associate Director of Chemoproteomics, the candidate will contribute to the design and implementation of workflows to screen chemical libraries using mass spectrometry-based chemoproteomics techniques. They will also perform proteomics experiments to characterize small molecule target engagement on proteins as well as help define the protein interaction networks of key oncology targets. The candidate will have the opportunity to employ multiple techniques in chemoproteomics in a dynamic start-up environment.


Job Description:


  • Conduct tissue culture of cancer cell lines to support chemoproteomic screening efforts
  • Optimize and conduct protocols for the preparation of chemoproteomic screening samples
  • Learn and execute mass spectrometry-based techniques to characterize small molecule binding of proteins
  • Use proteomics techniques to define protein interaction networks of key oncology targets
  • Present results regularly at team meetings
  • Perform diligent and timely note-keeping and work process tracking
  • Communicate science and strategy effectively in internal meetings and prepare written reports of data and literature analyses
  • Position mostly requires benchwork responsibilities


Required Qualifications:


  • PhD in Molecular/Cell Biology, Chemical Biology, Biochemistry or related field
  • Previous experience in academia or relevant biopharmaceutical industry is a plus
  • Track record of being able to work independently and to create new workflows
  • Excellent hands-on technical laboratory skills
  • Excellent written and oral communication skills
  • Attention to details in documenting, executing, and analyzing experiments
  • Desire and ability to work in a fast-paced startup environment
  • Flexibility and eagerness to tackle new tasks and challenges, and meet aggressive timelines
  • Ability to work closely with other group members within teams is essential


Preferred Qualifications


  • Experience with mass spectrometry-based proteomics techniques
  • Proficiency in mammalian cell line culture, especially large-scale projects
  • Experience in using 96-well assays to screen small molecule libraries
  • Experience in protein-protein interactions is a plus



We offer a competitive total compensation package, as well as working in a supportive team environment. This position is located in our San Diego office. We invite you to consider a career with Light Horse

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