Senior Research Associate – Biophysics SPR

3 months ago

Boston, United States Monte Rosa Therapeutics Full time

Senior Research Associate – Biophysics SPR & FRET

Location: Boston

Monte Rosa Therapeutics is seeking a passionate Senior Research Associate with the experience to implement and run biochemical and biophysics assays. This is an exciting opportunity to join a team responsible for the biochemical and biophysical characterization of novel small molecule glue-based degraders to support Monte Rosa’s growing pipeline. The successful candidate will have proven bench level expertise in establishing and performing a range of biochemical and biophysics assays to screen and characterize small molecule compounds and elucidate mechanism of action. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional teams, as well as demonstrate a high degree of independence and organization.


Principal Duties and Responsibilities

  • Design, develop and implement a variety of kinetic-focused, protein-protein interaction assays in low and high-throughput settings.
  • Standard assays include surface plasmon resonance (SPR), MST, Spectral Shift, Differential Scanning Fluorimetry (DSF), Flow-induced dispersion analysis (FIDA), TR-FRET, and fluorescence polarization (FP).
  • Screen and characterize small molecule compounds and determine the mode of action.
  • Analyze and interpret integrated datasets.
  • Maintain laboratory records, protocols, and summaries.
  • Contribute to laboratory organization and maintenance.
  • Present research plans and results, both within the team and to senior management.

Qualifications

  • BS/MS with at least 2 years pharma/biotech drug discovery laboratory experience in screening.
  • Skill in biochemical and biophysical assay development (fluorescence, TR-FRET, FP, MST, SPR, DSF, or ITC) with a strong background in biophysics.
  • Experience with various compound screening formats, laboratory instrumentation, and high throughput automation.
  • Experience with sample management processes and instrumentation.
  • Proven ability to work independently and design experiments, troubleshoot, interpret and report large datasets.
  • Highly analytical mind, attention to detail and organization skills are critical.
  • Experience with Biacore 8K+ and S200 is preferred.

Interested candidates should forward CV and cover letter to careers-us@monterosatx.com or apply on line www.monterosatx.com


About Monte Rosa

Monte Rosa Therapeutics is a clinical-stage biotechnology company developing highly selective molecular glue degrader (MGD) medicines for patients living with serious diseases in the areas of oncology, autoimmune and inflammatory diseases, and more. MGDs are small molecule protein degraders that have the potential to treat many diseases that other modalities, including other degraders, cannot. Monte Rosa’s QuEEN™ (Quantitative and Engineered Elimination of Neosubstrates) discovery engine combines AI-guided chemistry, diverse chemical libraries, structural biology and proteomics to identify degradable protein targets and rationally design MGDs with unprecedented selectivity. The QuEEN discovery engine enables access to a wide-ranging and differentiated target space of well-validated biology across multiple therapeutic areas. Monte Rosa has developed the industry’s leading pipeline of MGDs, which spans oncology, autoimmune and inflammatory disease and beyond, and has a strategic collaboration with Roche to discover and develop MGDs against targets in cancer and neurological diseases previously considered impossible to drug. For more information, visit www.monterosatx.com.

  • Senior Research Associate – Biophysics SPR

    2 months ago

    boston, United States Monte Rosa Therapeutics Full time

    Senior Research Associate – Biophysics SPR & FRETLocation: BostonMonte Rosa Therapeutics is seeking a passionate Senior Research Associate with the experience to implement and run biochemical and biophysics assays. This is an exciting opportunity to join a team responsible for the biochemical and biophysical characterization of novel small molecule...

  • Senior Research Associate – Biophysics SPR

    2 months ago

    boston, United States Monte Rosa Therapeutics Full time

    Senior Research Associate – Biophysics SPR & FRETLocation: BostonMonte Rosa Therapeutics is seeking a passionate Senior Research Associate with the experience to implement and run biochemical and biophysics assays. This is an exciting opportunity to join a team responsible for the biochemical and biophysical characterization of novel small molecule...

  • Senior Scientist, Biochemistry

    4 weeks ago

    Boston, MA, United States Tango Therapeutics Full time

    Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at...

  • Senior Ethnographic Researcher

    6 days ago

    Boston, Massachusetts, United States Lux Research, Inc. Full time

    Job Title: Senior Ethnographic ResearcherAbout Our Company: Lux Research, Inc. is an award-winning company that empowers businesses to make informed decisions through cutting-edge research. Job Overview: We are seeking a highly skilled Senior Ethnographic Researcher to join our team. This role involves conducting research projects, analyzing data, and...

  • Research Associate Diagnostic Technology

    4 days ago

    Boston, Massachusetts, United States GrapheneDx Full time

    Duties and ResponsibilitiesWe are seeking a highly motivated and adaptable individual to join our team as a Research Associate Diagnostic Technology. This role involves driving the development of a novel GFET-based point-of-care diagnostic platform. The successful candidate will design, execute, and optimize experiments for biomarker detection, perform data...

  • Senior Research Associate

    4 days ago

    Boston, Massachusetts, United States Managed Staffing Full time

    Job TitleSenior Research Associate / Sr Lab Tech / Research Associate (Pay Rate based on experience)We are seeking a Senior Research Associate at Boston, MAThis is a full-time position with a competitive salary range of $60,000 - $80,000 per year, depending on experience.Key ResponsibilitiesConduct laboratory experiments, including data collection and...

  • Senior Research Scientist

    4 weeks ago

    Boston, Massachusetts, United States GrapheneDx Full time

    About GrapheneDxWe are a cutting-edge diagnostics technology company dedicated to transforming consumer diagnostics. Our team provides an environment for multidisciplinary growth, opportunities to acquire new skills, and collaborations with accomplished professionals.At GrapheneDx, we offer competitive compensation including a base salary of $120,000,...

  • Senior Clinical Research Associate

    2 days ago

    Boston, United States Discover International Full time

    Senior Clinical Research Associate (CRA) - Oncology BiotechLocation: Remote (US-based)About Us: We are a passionate team dedicated to advancing transformative therapies to improve the lives of patients with cancer and other serious diseases. By harnessing cutting-edge science and innovative approaches, we are committed to bringing new hope to patients and...

  • Senior Clinical Research Associate

    2 weeks ago

    Boston, United States Discover International Full time

    Senior Clinical Research Associate (CRA) - Oncology BiotechLocation: Remote (US-based)About Us: We are a passionate team dedicated to advancing transformative therapies to improve the lives of patients with cancer and other serious diseases. By harnessing cutting-edge science and innovative approaches, we are committed to bringing new hope to patients and...

  • Research Senior Associate

    3 weeks ago

    Boston, United States Takeda Pharmaceutical Full time

    By clicking the Apply button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takedas Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge. Job...

  • Senior Molecular Biology Research Associate

    2 weeks ago

    Boston, Massachusetts, United States Centaura Full time

    Job OverviewWe are seeking a highly motivated and experienced Senior Molecular Biology Research Associate to join our team at Centaura.Key Responsibilities:Experiment Support: Provide technical expertise and support for ongoing experiments, including the construction and delivery of Human Artificial Chromosomes (HACs) into human cells, as well as designing...

  • Associate/Research Associate in Microbiology

    3 weeks ago

    Boston, United States Harvard University Full time

    Associate/Research Associate in Microbiology Title: Associate/Research Associate in Microbiology School: Harvard School of Dental Medicine Department/Area: Oral Medicine, Infection, and Immunity Position Description: Under direction of the Principal Investigator and Senior Research Associate, the Associate/Research Associate in Microbiology will provide...

  • Abiologics, Inc | Boston, MA Senior Machine Learning Researcher

    4 weeks ago

    Boston, United States Flagship Ventures Full time

    Company Overview: Abiologics, Inc. is a privately held, early-stage biotechnology company on a mission to make biology better through chemistry. We are pioneering the development of Synteins TM, a transformational class of macromolecular medicines unlocked by novel synthetic and computational technologies. Abiologics is actively seeking exceptional molecular...

  • Discover International | Senior Clinical Research Associate

    2 weeks ago

    boston, United States Discover International Full time

    Senior Clinical Research Associate (CRA) - Oncology BiotechLocation: Remote (US-based)About Us: We are a passionate team dedicated to advancing transformative therapies to improve the lives of patients with cancer and other serious diseases. By harnessing cutting-edge science and innovative approaches, we are committed to bringing new hope to patients and...

  • Research Senior Associate

    1 month ago

    Boston, United States Takeda Pharmaceutical Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job...

  • Senior Research Associate

    4 weeks ago

    Boston, Massachusetts, United States Takeda Pharmaceutical Full time

    Job SummaryWe are seeking a highly skilled Senior Research Associate to join our In Vitro Pharmacology team in Boston, MA. As a key member of our team, you will support the development and evaluation of novel therapeutics in Oncology, Gastroenterology, and Neuroscience.About the RoleThis role is part of our Global Biologics organization, where you will work...

  • Research Senior Associate

    4 weeks ago

    Boston, United States Takeda Pharmaceutical Full time

    By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's Privacy Notice and Terms of Use . I further attest that all information I submit in my employment application is true to the best of my knowledge. Job...

  • Research Associate

    21 hours ago

    Boston, MA, United States Tufts University Full time

    OverviewThe Department of Developmental, Molecular and Chemical Biology is a Basic Science research department in the School of Medicine. Members of the department carry out research on fundamental and medically related problems in different aspects of cell biology. What You'll DoWork in collaboration with the senior investigator in the host laboratory. S/he...

  • Research Associate

    21 hours ago

    Boston, MA, United States Tufts University Full time

    OverviewThe Department of Developmental, Molecular and Chemical Biology is a Basic Science research department in the School of Medicine. Members of the department carry out research on fundamental and medically related problems in different aspects of cell biology. What You'll DoWork in collaboration with the senior investigator in the host laboratory. S/he...

  • Scientific Editor

    4 weeks ago

    Boston, Massachusetts, United States American Association for Cancer Research Full time

    The American Association for Cancer Research is seeking a highly skilled Scientific Editor to join our editorial team. This exciting opportunity will see the successful candidate assess submitted manuscripts and referrals, solicit high-quality submissions, write and edit content, and promote the journal through outreach and networking efforts.About the...