Research Associate, Antivirals

3 weeks ago

Canton, United States Pledge Therapeutics Full time

Job Title: Research Associate-Antiviral

Company: Pledge Therapeutics

Location: Canton, MA


About us

Pledge Therapeutics is a dynamic and growing place to work. We are developing multiple, first-in-class, small-molecule medicines against challenging targets across a wide range of disease areas, particularly antivirals, and anti-infectives.


Our efforts have given rise to a constellation of exciting discoveries, spanning hit-generation to preclinical drug development of first-in-class antiviral therapeutics. We have also developed the first antiviral therapeutic for a virus that causes complications in transplant and immune-compromised patients. Our success is based on the rapid translation of unique clinical and translational insights and the integration of structural and biophysical knowledge of disease targets to accelerate the pace of drug development. We pride ourselves on working with interdisciplinary research groups and partnering with leading drug development teams across the world to realize our mission of improving the lives of patients.


Job Description: Research Associate


We seek an enthusiastic and curious scientist interested in taking part in all aspects of the hit-to-lead drug discovery process. The opening is at our new state-of-the-art facility in Canton, MA.


The successful candidate will engage in different research areas of the company and will work with a successful team of international senior scientists located in the USA and EU. The ideal candidate will have great communication skills, excellent technical skills, exemplary attention to detail, and a passion for learning. This position will have the opportunity to become part of an exciting, startup company and make significant scientific contributions to numerous drug discovery projects.



Responsibilities:


  • Maintain multiple mammalian cell lines and optimize them for viral production and viral assays.
  • Perform in-vitro experiments with flexibility and precision, meeting ongoing demands and establishing best practices to maximize tissue culture outputs.
  • Conduct High Throughput Screening of compounds or libraries using DSF and ELISA assay techniques, among others.
  • Maintain excellent written records of performed experiments, and work with colleagues to develop companywide SOPs.
  • Prepare reports of completed projects for presentation to company personnel.
  • Help organize laboratory inventory, reagent ordering, and other daily or extraordinary laboratory activities.
  • Provide additional research support and assistance to research tasks requested by senior management.
  • Collaborates cross-functionally with other team members to ensure that daily operations and timelines are met.



Education and Experience:


  • One year of consistent work in the viral field, including viral titrating, RT-PCR, plaque assay etc.
  • Phd in Virology or related field, Master in Sciences degree in cellular or molecular biology, or related field and 1-5 years of experience in academic or industry research
  • Previous laboratory experience in tissue culture and viral production required
  • Experience working with Small Molecule, HTS screening, PCR, qPCR, Elisa
  • Organized with a strong work ethic and the ability to juggle different tasks
  • Able to work in a team and willing to present data to our international partners



If you are ready to roll up your sleeves, are passionate about solving challenging problems with creativity, and want to be part of an exciting and growing company, please send us your CV and a note to mmartin@pledge-tx.com


Job Type: Full-time, On-Site, Equal Opportunity Employment

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