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Process Development Sr Scientist- Mass Spectrometry
1 month ago
HOW MIGHT YOU DEFY IMAGINATION?
Youve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.
Process Development Sr Scientist- Mass SpectrometryLive
What you will do
Lets do this Lets change the world
Amgen is a leading biotechnology company with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses.
Amgens Attribute Sciences (AS) department within the Process Development (PD) organization defines the favorable quality characteristics of the therapies it produces and optimizes state-of-the-art analytical tools to guide that development. The Pivotal PD organizations focus is developing and commercializing robust manufacturing processes across a wide range of therapeutic modalities, including (but not limited to) monoclonal and bispecific antibodies, bispecific T-cell engagers (BiTEs), live oncolytic viruses, and synthetic medicines.
Located in our Thousand Oaks, CA office, the PD Sr Scientist will work supporting product characterization and method development for clinical candidate molecules in the pivotal stage of development.Key Responsibilities:
Identifying and characterizing attributes of therapeutic proteins and synthetic molecules using advanced analytical techniques
Develop and apply novel sample preparation and analytical methods for analysis of therapeutic proteins and synthetic molecules with emphasis on chromatography and mass spectrometry (LC-MS/MS)
Assess a variety of quality attributes of therapeutic proteins with emphasis on chemical modifications including glycosylation, oxidation, deamidation, aspartate isomerization, hydroxylation and others
Work in an analytical group equipped with a variety of chromatographic systems and mass spectrometry platforms
Perform LC/MS analyses of therapeutic proteins using intact, reduced protein and peptide mapping, different chromatographic and electrophoretic techniques
Communicate (verbal and in written) scientific concepts and results
Follow protocols and procedures, maintain accurate records in an electronic lab notebook, and generate quality data for use in drug development and regulatory filings
Work collaboratively with other scientists on multidisciplinary teams
Work independently in advancing projects and studies within required deadlines
Actively create or contribute to patent and publications
Keep current with field of expertise, participate and advance drug development, technologies and information services programs within Amgen
Must have mass spectrometry experienceWin
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an employee with these qualifications.Basic Qualifications:
Doctorate degree or doctorate degree by December 2023 OR
Masters degree and 4 years of pharmaceutical-biotechnology and/or CRO industry and/or Scientific experience OR
Bachelors degree and 6 years of pharmaceutical-biotechnology and/or CRO industry and/or Scientific experiencePreferred Qualifications:
Ph.D. in Analytical Chemistry, Biochemistry with emphasis in mass spectrometry
2 or more years post-PhD experience in the pharmaceutical or biotech industry in process and product development and drug substance and drug product analytical method development
Documented theoretical knowledge and hand-on experience in peptide mapping of proteins, intact and reduced LC-MS analysis for identification and quantification of chemical modifications
Training and experience of operating Thermo Q-Exactive mass spectrometers, Agilent mass spectrometers, and Agilent and Waters HPLCs and UHPLCs and associated data processing software (including empower, chromeleon, biopharmafinder, mass hunter, etc.)
Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects
Knowledge of statistical processing of data, including related software like Excel, Spotfire & JMP
Knowledge of programming using R, Python, C++, or machine learning languages
Demonstrated proficiency in solving complex problems, ability to work independently, proactively seek outside resources and collaborate, self-starter and team player with strong leadership and decision-making skills capable of providing mentorship to junior staffThrive
What you can expect of us
As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.
Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:
Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans and bi-annual company-wide shutdowns
Flexible work models, including remote work arrangements, where possibleApply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.careers.amgen.com
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
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