Computational Scientist, Protein Library Design

3 months ago


Boston, United States Manifold Bio Full time
  • Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering.
  • Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process.
  • We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics.
  • Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.
  • Manifold Bio is seeking an exceptional Computational Scientist to join our growing Compute team.
  • You will work closely with experimental and hybrid scientists to design and analyze highly multiplexed protein library experiments.
  • You will be expected to own and independently advance projects in areas related to your deep expertise such as protein design, DNA library design, or machine learning/biophysical modeling from MPRA data.
  • You will work closely with our CSO and our other computational scientists to onboard new capabilities that advance the M-Design platform for data-driven engineering of drugs with desired properties.


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