Principal Scientist, Biotransformation

Found in: Jooble US O C2 - 2 weeks ago

Boston MA, United States Cerevel Therapeutics, LLC Full time

**Principal Scientist, Biotransformation**

Posted: 08/03/2021

Boston, MA

**Company Overview**

Cerevel Therapeutics is dedicated to unraveling the mysteries of the brain to treat neuroscience diseases. We are tackling neuroscience diseases with a differentiated approach that combines expertise in neurocircuitry with a focus on receptor selectivity. Our portfolio of pre-commercial neuroscience assets targets a broad range of central nervous system (CNS) disorders, including schizophrenia, epilepsy, Parkinsons disease and substance use disorder.

Headquartered in the Greater Boston area, we are bold thinkers, deep experts, resilient pathfinders, and transparent partners who push the boundaries of scientific understanding to unlock breakthrough CNS therapies that have real impact on peoples lives.

Cerevel aspires to develop and nurture a culture characterized by trust, respect, courage, curiosity, and compassion, with a relentless focus on mission and results. Our patient-centricity guides our purpose, how we treat each other and what we work on every day. The successful candidate will bring their own unique thinking and approach to Cerevel while sharing our core values and convictions.

**Role Summary**

**We are seeking an exceptional individual for a Principal Scientist position within the DMPK group. The successful candidate will have a strong experimental background with an established track record of hands on in vitro/in vivo ADME assay support and technical problem solving. A true experimentalist, the successful candidate ideally has experience supporting and influencing projects with in vitro/in vivo metabolic profiling and identification studies in drug development and/or discovery. Experience in discovery bioanalysis for in vivo PK studies is also helpful. At the senior level, this person will be troubleshooting as well as analytical method problem solving (HRMS/LC- MS/MS) across the discovery & development projects.**

****Key Responsibilities****

* **Design and delivery of fit-for-purpose in vitro/ in vivo metabolic profiling and identification experiments to support discovery or development projects**

* **Independently able to develop, implement and/or troubleshoot analytical methods for analysis of drug metabolites, conduct metabolic profiling and collect appropriate instrumentation data for the determination of metabolite structures and associated pathways**

* **Experience in isolation of metabolites from different matrices and structural elucidation**

* **Be able to troubleshoot, problem solve and define best practice for in vitro ADME experiments**

* **Work closely within DMPK, Cross functional groups and subject matter experts to ensure that in vitro/in vivo DMPK technologies and science are relevant for project teams and portfolio deliverables**

* **Contribute to the scientific in vitro strategy to enhance the value of in vitro DMPK science to support a diversified Cerevel portfolio**

* **Report and communicate scientific ideas and results to senior leaders as needed**

* **Present and publish findings to project teams/Cerevel/external scientific community**

* **Ensure data integrity and data accessibility through the Cerevel R&D data domains**

* **Ensure compliance with Cerevel Values and Policies**

****Required Qualifications****

* **Strong understanding of drug metabolism and ADME principles including enzyme kinetics, analytical method development, metabolite profiling and structural elucidation**

* **In depth experience with in vitro ADME assays, HRMS, bioanalysis and LC-MS/MS**

* **In depth knowledge of laboratory equipment and troubleshooting instrumentation issues, high resolution mass spectrometry with particular focus on MS and MS/MS data collection and basic interpretation**

* **Working knowledge with radiolabeled compounds and samples is preferred**

* **Experience working with project teams to guide them through ADME problem solving using in vitro data would be preferred**

* **Experience in writing and reviewing in vitro reports for regulatory filing is highly desired**

****Desired Qualifications****

* **5+ years of industrial experience in DMPK departments in a drug discovery setting**

* **Previous experience with HRMS for metabolite profiling and identification, automated workflows and LC-MS/MS analysis**

* **Experience in bioanalysis, automation and liquid handling systems would be a plus**

****Education****

* **MS or PhD in organic chemistry, analytical chemistry, Drug Metabolism and Pharmacokinetics or related science such as Pharmacology, Biology, Biochemistry**

#J-18808-Ljbffr

  • Principal Scientist, Oligonucleotide Synthesis

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States EPM Scientific - Phaidon International Full time

    A global pharmaceutical manufacturing company located in the Boston region is looking to add a skilled Principal Scientist to their chemical development team. This individual will need to have expertise in oligonucleotide chemistry and process optimization in both early and late stage. The preferred candidate will also have past experience with the...

  • Principal Scientist, Analytical Development

    3 days ago

    Boston, United States EPM Scientific Full time

    Job DescriptionJob DescriptionPrincipal Scientist - Analytical DevelopmentLocation: Boston, MALevel: Principal ScientistSUMMARYA premier, mid-sized pharmaceutical company is actively hiring a Principal Scientist for their analytical development team. You will be playing a pivotal role in leading scientific initiatives and collaborating with cross-functional...

  • Sr. Scientist/Principal Scientist- Protein Sciences

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Third Rock Ventures Full time

    Sr. Scientist/Principal Scientist– Protein Biochemist A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of...

  • Sr. Scientist/Principal Scientist- Protein Sciences

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Third Rock Ventures Full time

    Sr. Scientist/Principal Scientist Protein Biochemist A stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of...

  • Pharmacometrician Principal Scientist

    Found in: Jooble US O C2 - 3 days ago

    Boston, MA, United States Olla Cocina Full time

    Agricultural Equipment Lending Coordinator Academic Coordinator I (F3/LFFI) UC Agriculture and Natural Resources Parlier, CA 93648 posted 04/22/2024 More... front runner Acute Care Sales Representative, Therapeutic Nutrition - Fresno, CA Abbott Fresno, CA 93744 posted 04/21/2024 More... front runner Project Scientist - Pediatrics - Arditi Lab...

  • Senior/Principal Scientist- Biophysical Characterization

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Aura Biosciences Full time

    At Aura, our mission is to develop a new class of oncology targeted therapies that deliver meaningful therapeutic benefit to a range of cancer indications with high unmet need in which we believe we can establish a new standard of care. We are driven by our passion and commitment to science and the patients battling cancer who are relying on us to pioneer...

  • Director of DMPK

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States RBW Consulting Full time

    RBW are currently working in close partnership with a global biopharmaceutical company that are looking for a new Director of ADME/DMPK to join their team. You will be responsible for developing the DMPK strategy across all metabolism related aspects such as in vitro ADME, bioanalysis, biotransformation and transporters. This opportunity will also involve...

  • Principal Scientist, Clinical Biomarkers

    Found in: Jooble US O C2 - 3 days ago

    Boston, MA, United States Meet Full time

    Our client is a clinical stage biotechnology company dedicated to developing groundbreaking therapeutics that target neuromuscular disease and other hard to treat conditions. Their mission is to make a profound impact on patients' lives by pioneering first-in-class biologics and innovative treatments. As a Senior/Principal Scientist in Clinical...

  • Principal Research Scientist

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Alice & Bob Full time

    Alice&Bob is developing the first universal, fault-tolerant quantum computer to solve the world’s hardest problems. The quantum computer we envision building is based on a new kind of superconducting qubit: the Schrödinger cat qubit. In comparison to other superconducting platforms, cat qubits have the astonishing ability to implement quantum error...

  • PRINCIPAL RESEARCH ASSOCIATE/ASSOCIATE SCIENTIST, CELL BIOLOGY

    Found in: Careerbuilder One Red US C2 - 18 hours ago

    Boston, MA 02298, USA, United States Magnet Biomedicine Full time

    Principal Research Associate/Associate Scientist, Cell BiologyAbout Magnet BiomedicineMagnet Biomedicine is a fast-paced, collaborative, venture-backed startup developing rational approaches to molecular glue discovery. Magnet's TrueGlueTM Discovery Platform enables the discovery and development of fit-for-purpose molecular glue strategies to target a...

  • Senior/Principal Scientist- Biophysical Characterization

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Aura Biosciences Full time

    Job Description Job Description Salary: About Aura: At Aura, our mission is to develop a new class of oncology targeted therapies that deliver meaningful therapeutic benefit to a range of cancer indications with high unmet need in which we believe we can establish a new standard of care. We are driven by our passion and commitment to science and the...

  • Principal Scientist

    Found in: Appcast Linkedin GBL C2 - 2 weeks ago

    Boston, United States Scienta Full time

    Company – A leading Biotechnology Cell Therapy company Location – Boston, on site About the company This company focuses on developing cell therapies to treat cancer.They are seeking Scientists on all levels from Associate Researcher to Senior Scientists to join the cell Biology and Immunology Research and Development department. Duties Plan and design...

  • Principal Scientist

    Found in: Appcast US C2 - 1 week ago

    Boston, United States Scienta Full time

    Company – A leading Biotechnology Cell Therapy company Location – Boston, on site About the company This company focuses on developing cell therapies to treat cancer.They are seeking Scientists on all levels from Associate Researcher to Senior Scientists to join the cell Biology and Immunology Research and Development department. Duties Plan and design...

  • Principal Research Scientist

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Alice & Bob Full time

    Alice&Bob is developing the first universal, fault-tolerant quantum computer to solve the world’s hardest problems. The quantum computer we envision building is based on a new kind of superconducting qubit: the Schrödinger cat qubit. In comparison to other superconducting platforms, cat qubits have the astonishing ability to implement quantum error...

  • Sr. Scientist/Principal Scientist– Protein Sciences

    Found in: Appcast US C2 - 1 week ago

    Boston, United States Third Rock Ventures Full time

    Sr. Scientist/Principal Scientist– Protein BiochemistA stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of...

  • Sr. Scientist/Principal Scientist– Protein Sciences

    Found in: Appcast Linkedin GBL C2 - 2 weeks ago

    Boston, United States Third Rock Ventures Full time

    Sr. Scientist/Principal Scientist– Protein BiochemistA stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of...

  • Sr. Scientist/Principal Scientist– Protein Sciences

    3 days ago

    Boston, United States Third Rock Ventures Full time

    Sr. Scientist/Principal Scientist– Protein BiochemistA stealth mode Third Rock Ventures start up is seeking a dynamic and motivated Biochemist/Biophysicist with significant experience in Drug Discovery to become an integral part of the Discovery Biologics group. The successful candidate will spearhead the development and execution of a diverse range of...

  • Director of DMPK

    Found in: beBee S US - 2 weeks ago

    Boston, United States RBW Consulting Full time

    RBW are currently working in close partnership with a global biopharmaceutical company that are looking for a new Director of ADME/DMPK to join their team. You will be responsible for developing the DMPK strategy across all metabolism related aspects such as in vitro ADME, bioanalysis, biotransformation and transporters. This opportunity will also involve...

  • RESEARCH SCIENTIST

    Found in: Careerbuilder One Red US C2 - 22 hours ago

    Boston, MA 02298, USA, United States Partners Healthcare System Full time

    GENERAL SUMMARY/ OVERVIEW STATEMENT:The Research Scientist functions independently and in collaboration with principal investigators and other faculty members to develop complex research study designs and conduct analyses in pharmacoepidemiology, epidemiology/biostatistics, and analytic methods. Prepares scientific reports, manuscripts, presentations, and...

  • Principal Data Scientist

    Found in: Jooble US O C2 - 2 weeks ago

    Boston, MA, United States Whoop Full time

    At WHOOP, we're on a mission to unlock human performance. WHOOP empowers users to perform at a higher level through a deeper understanding of their bodies and daily lives. As a member of the Data Science team, you will develop data-driven features to provide a personalized, contextual, and adaptable coaching experience, guiding members toward their...