Associate Scientist

4 days ago


South San Francisco, United States Integrated Resources, Inc ( IRI ) Full time

The Translational Medicine, Associate Scientist II will be a member of the DMPK function providing expertise as a key component of the multi-disciplinary drug discovery effort in RL South San Francisco, with a focus on supporting preclinical development of next generation biologics, antibody drug conjugates (Client), and small molecule using liquid chromatography-mass spectrometry (LC-MS) technologies.

• The scientist will contribute to the biotransformation investigation of next gen biologics and Antibody Drug Conjugate (Client) using liquid chromatography-mass spectrometry (LC-MS).

• The candidate will also contribute to small molecule bioanalysis of in vivo PK samples.

• Ideal candidate is expected to support the in vitro and in vivo biotransformation study via sample preparation and LC-MS analysis, support the bioanalysis of small molecule in PK study, and supervise LC-MS lab operations including lab housekeeping, instrument maintenance and troubleshooting.


Quals:

• Ph.D. with 0-2 years in analytical chemistry, biochemistry, chemical biology, cell biology, pharmaceutical sciences, biology, chemistry, pharmacology, biochemical engineering or a related discipline.

• MS/BS Degree with a minimum of 3-5 years of relevant experience.


Required Experience and Skills:

• Experience with LC-MS technologies.

• Experience with maintaining and troubleshooting HPLC and mass spectrometers

• Demonstrated hands-on experience in protein/pepProduct identification, quantitation and characterization using mass spectrometers.

• Highly motivated, self-driven and results-oriented individual with excellent communication skills.

• An excellent team player that can closely collaborate with internal and external collaborators

• The successful candidate should be an experienced scientist with knowledge and hands on experience in quantitative/qualitative mass spec analysis of protein/pepProduct and/or small molecule entities.

• The candidate must be able to work collaboratively in a fast-paced environment and have excellent scientific, interpersonal and communication skills.

• Hands on experience with bioanalytical technologies a plus.

• The candidate must be able to work collaboratively in a fast-paced environment and have excellent scientific, interpersonal and communication skills.


Preferred Experience and Skills:

• Previous experience in automation instruments such as Assaymap and Hamilton is a plus.

• Previous experience with Watson LIMS, Sciex Triple Quads and MultiQuant is a plus but not required.

• Previous experience in drug discovery and development is a plus but not required.

• High learning agility and a willingness to contribute to all levels within the DMPK group.

• Comfortable with risk taking and undertaking hypothesis-driven experimentation.


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