Associate Director/Principal Scientist, hiPSC Platform, Neuroscience

Found in: Appcast US C2 - 2 weeks ago


Pasadena, United States AcuraStem Full time

Company Description

AcuraStem is a patient-based biotechnology company pioneering treatments for neurodegenerative diseases, including ALS and FTD. AcuraStem’s best-in-class disease modeling platform, iNeuroRx®, enables the discovery of innovative, effective, and broadly acting treatments. The team’s strong expertise in ASO technology provides for the rapid advancement of treatments in the clinic. AcuraStem’s research is funded in part by support from the Alzheimer’s Drug Discovery Foundation, Harrington Discovery Institute, Alzheimer’s Association, Rainwater Charitable Foundation, Muscular Dystrophy Association, Department of Defense, and the National Institute of Neurological Disorders and Stroke.


Role Description

This is a full-time on-site role for an Associate Director/Principal Scientist, hiPSC Platform, Neuroscience. The Associate Director/Principal Scientist is expected to manage and advance AcuraStem’s current platform technology, which utilizes human iPSC-derived various CNS cell types to model neurodegenerative disease to re-capitulate disease phenotypes. The platform will be employed for target discovery/ validation, lead selection, and biomarker evaluation. AcuraStem seeks individuals with deep knowledge of iPSC neurodegenerative disease models, high-content imaging, and assay development. The candidate will manage external collaborations and work with internal cross-functional teams to advance early discovery research milestones. The successful candidate will be a passionate individual who is persistent and tenacious in developing novel technology and executing a plan with high-quality scientific results. The position is responsible for aligning the strategic direction of the platform team with the overall business strategy. It will leverage innovation in developing and commercializing new, high-performance, and cost-optimized assays. The Associate Director/Principal Scientist is a technical and business mentor, leader, and coach for the platform team.


Responsibilities


●     Develop and deploy innovative all-human platforms to enable target validation and lead optimization.

●     Plans and executes assay development activities through the product development cycle's feasibility, development, validation, and transfer stages.

●     Applies analytical techniques, including design of experiments (DoE) and statistical process control (SPC) to diagnose assay performance issues. Conducts statistical analysis and develops solutions to improve assay performance by reducing variability and modifying assay designs.

●     Present results to internal and external audiences, including the leadership team, partnership organizations, and scientific conferences.

●     Strong commitment to mentoring staff and promoting individual growth and career development.


Qualifications

• Ph.D. with expertise in multiple neuroscience areas. ALS, FTD, Tauopathies or oligonucleotide therapy experience

• A minimum of 4 years of industry experience is required for the Principal Scientist level, and 6+ years is required for the Associate Director level.

• Deep knowledge in assay development using human stem cell/iPSC-derived neurons and organoids for neurodegenerative disease models.

• Experience in drug discovery program from early stages to IND, or experience at multiple stages and the clear readiness to lead efforts across all stages.

• Work experience in a matrixed environment; small company and start-up experience preferred.

• High level of motivation and proven record of accomplishment

• Experience performing and analyzing various molecular and cell biology experiments.

• Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic, excellent communication abilities, and time management skills.



  • Pasadena, United States AcuraStem Full time

    Company DescriptionAcuraStem is a patient-based biotechnology company pioneering treatments for neurodegenerative diseases, including ALS and FTD. AcuraStem’s best-in-class disease modeling platform, iNeuroRx®, enables the discovery of innovative, effective, and broadly acting treatments. The team’s strong expertise in ASO technology provides for the...

  • Clinical Laboratory Scientist

    Found in: Lensa US P 2 C2 - 2 weeks ago


    Pasadena, United States Huntington Hospital Inc Full time

    ** Internal Workers - Please log into your Workday account to apply **Huntington Hospital Employee LoginCompensation Range:$51.64 - $74.74 / HourDepartment:750200 MicrobiologyExpectations:Performs a variety of standardized tests and procedures in conjunction with associated clerical and quality assurance functions. Works with minimal supervision and may be...


  • Pasadena, United States Caltech Full time

    The purpose of Advancement and Alumni Relations (AAR) is to foster a thriving and engaged community of support for Caltech. By connecting the people who share and support Caltech’s mission and values, we will ensure the Institute receives the necessary resources to achieve Caltech’s aspirations and sustain its excellence in teaching, research, and...


  • Pasadena, California, United States Caltech Full time

    The purpose of Advancement and Alumni Relations (AAR) is tofoster a thriving and engaged community of support for Caltech. Byconnecting the people who share and support Caltech's mission andvalues, we will ensure the Institute receives the necessaryresources to achieve Caltech's aspirations and sustain itsexcellence in teaching, research, and scholarship...

  • Director Chemical Biology and Peptide Macrocycles

    Found in: beBee jobs US - 3 weeks ago


    Pasadena, California, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...

  • Director Chemical Biology and Peptide Macrocycles

    Found in: beBee S US - 3 weeks ago


    Pasadena, United States Eli Lilly and Company Full time

    At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities...


  • Pasadena, United States Arrowhead Pharmaceuticals, Inc. Full time

    The Position The Associate Medical Director/Medical Director will report to the head of cardiometabolic clinical development and will be instrumental in bringing important new therapies based on RNA interference to patients. This individual will work collaboratively with Arrowhead's scientific and clinical teams to take drugs from late clinical research to...


  • Pasadena, United States Amazon Development Center U.S., Inc. Full time

    Ph.D. in physics, electrical engineering, materials science, or a related field in science or engineering - A demonstrated track record of original, impactful work done micro-/nano-fabrication - Hands-on experience with electron beam lithography; photolithography (mask or maskless aligners, steppers, and scanners); wafer-level wet/dry etching techniques;...

  • Clinical Laboratory Scientist Per Diem

    Found in: Lensa US P 2 C2 - 3 weeks ago


    Pasadena, United States Huntington Hospital Inc Full time

    ** Internal Workers - Please log into your Workday account to apply **Huntington Hospital Employee LoginCompensation Range:$66.76 - $66.76 / HourDepartment:750100 HematologyExpectations:Performs a variety of standardized tests and procedures in conjunction with associated clerical and quality assurance functions. Works with minimal supervision and may be...


  • Pasadena, United States Integrity College of Health Full time

    **Summary**: The Associate Director of Admissions serves as the admissions leader and manager of Career Advisors and is directly responsible and accountable for meeting recruitment goals and ensuring the quality of student recruitment. **Essential Duties and Responsibilities**: - Hire, develop and provide on-going training for career advisors. - Managing...

  • Research Scientist

    17 hours ago


    Pasadena, United States Caltech Full time

    Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community.Job Summary The Research...

  • REGISTERED NURSE 12HR

    Found in: Careerbuilder One Red US C2 - 7 days ago


    Pasadena, CA 91101, USA, United States Huntington Hospital Full time

    When you join the Huntington Hospital team, you are aligning yourself with an organization whose values drive our philosophy of compassionate community care. Over the past 129 years, we've grown from a small 16-bed hospital to a nationally recognized healthcare leader with 619 beds. As part of our commitment to providing equitable, high-quality care to all...


  • Pasadena, United States Caltech Full time

    Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community.Job Summary Under general...

  • Associate Attorney

    Found in: Appcast US C2 - 6 days ago


    Pasadena, United States Robert Half Full time

    REMOTE ATTORNEY OPPORTUNITY! Robert Half Legal is partnering with an established, stable law firm based in Los Angeles that is looking for an associate attorney. This position can be 100% remote, but the firm has an office space in Pasadena for attorneys who are interested in working locally.Responsibilities of Role: A-Z case management of insurance defense...

  • Associate Attorney

    5 days ago


    Pasadena, United States Robert Half Full time

    REMOTE ATTORNEY OPPORTUNITY! Robert Half Legal is partnering with an established, stable law firm based in Los Angeles that is looking for an associate attorney. This position can be 100% remote, but the firm has an office space in Pasadena for attorneys who are interested in working locally.Responsibilities of Role: A-Z case management of insurance defense...

  • Associate Attorney

    Found in: Appcast Linkedin GBL C2 - 3 weeks ago


    Pasadena, United States Robert Half Full time

    REMOTE ATTORNEY OPPORTUNITY! Robert Half Legal is partnering with an established, stable law firm based in Los Angeles that is looking for an associate attorney. This position can be 100% remote, but the firm has an office space in Pasadena for attorneys who are interested in working locally.Responsibilities of Role: A-Z case management of insurance defense...

  • Camp Director

    1 week ago


    Pasadena, United States The Y of Central Maryland Full time

    Overwhelmingly, people who decide they want to be a part of the Y in Central Maryland tell us they do so because it reflects their values and a conscious decision, they've made about how they choose to live their lives. The happiest and most fulfilled Y associates are those who are motivated to help others and who want to be a part of something larger than...

  • Digital and Retail Sales Associate

    Found in: Appcast Linkedin GBL C2 - 3 weeks ago


    Pasadena, United States A Leading Role Full time

    Job Title: Digital and Retail Sales AssociateJob Summary: We are seeking a creative and detail-oriented Digital and Retail Sales Associate to join our team. The ideal candidate will play a crucial role in driving in-store retail sales, managing inventory and fulfillment on our e-commerce platforms, and executing effective social media strategies. This...

  • ASSOCIATE MEDICAL DIRECTOR/MEDICAL DIRECTOR

    Found in: Careerbuilder One Red US C2 - 2 days ago


    Pasadena, CA 91101, USA, United States Arrowhead Pharmaceuticals, Inc. Full time

    The PositionThe Associate Medical Director/Medical Director will report to the head of cardiometabolic clinical development and will be instrumental in bringing important new therapies based on RNA interference to patients. This individual will work collaboratively with Arrowhead's scientific and clinical teams to take drugs from late clinical research to...

  • Head Groundskeeper

    1 week ago


    Pasadena, United States Heritage Estate Management Full time

    Job DescriptionJob DescriptionHistoric 3 acre private estate is seeking a Groundskeeper Manager. This is a true hybrid position of groundskeeping and garden horticulturist. The candidate will work closely with a renowned landscape architect to support the maintenance, restoration, and implementation of future projects. The candidate should bring management...