Senior Scientist Bioinformatics, Biologics Engineering, Oncology R&D

Found in: Talent US C2 - 2 weeks ago

Gaithersburg, United States AstraZeneca Full time

In this role you form part of a Bioinformatics team working at the cutting edge of research and development in antibody engineering to build and maintain novel bioinformatics pipelines, customising NGS workflows, integrating ML approaches to better inform lab experiments. You will also work closely with data management, software engineering, computational modelling, and machine learning team members with access to industry-leading biologics R&D data across AstraZeneca.

ASTRAZENECA

Withoneof the broadest and deepestOncology pipelines in the industry, therearemanyopportunities to workwithnoveldrugs and helpdiscoverwhat'snext. We foster a mindsetofcourage, whereeveryone is empowered to step up, innovate and work at pace. Weleadthroughtruecollaboration, buildingcollectivewisdom by givingeveryone a chance to input. It's science with an impact-making a difference for patients and peoplearound the world.

SITE DESCRIPTION

The Gaithersburg site () employs more than 3,500 experts in our field and is only a short drive from Washington, DC. Here, we play host to some of the most cutting-edge technology and lab spaces, all crafted to inspire collaboration and cross-functional science. The Gaithersburg campus offers a variety of amenities to help boost efficiency and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, game rooms, community garden and much more.

BUSINESS AREA

Join the Biologics Engineering team at AstraZeneca, where we are responsible for the discovery and optimisation of next-generation biological drug candidates across all key therapy areas. We are developing in-house biologics discovery platforms and novel drug modalities to address unmet medical needs. BE empowered to act fast on smart risks and keep ahead in the fast-paced Oncology field.

What you'll do

The Bioinformatics team is growing to meet the strategic challenges pursued by AZ Biologics Engineering. We are looking for a Senior Bioinformatician to join our Biologics Engineering Bioinformatics team. The role will focus on our expanding needs for NGS for antibody discovery across all therapeutic areas. 

Create, automate and maintain Bioinformatics workflows, using NGS data, and guide antibody discovery platforms to explore antibody repertoire.

Apply the latest computational approaches to antibody sequencing data; proactively devise and implement innovative bioinformatic solutions with a focus on biologics engineering.

Use your knowledge of NGS, drug development and data science to deliver actionable impacts for all therapeutic areas within AZ.

Collaborate closely with AZ colleagues in data management, software engineering, computational modeling, and machine learning to drive effective data generation and help address technology/analytics gaps in creating end-to-end workflows.

Contribute bioinformatics expertise to the application and development of cutting-edge sequencing technologies in key strategic growth areas.

Publish work in high impact journals with industry and academic partners to increase visibility of AZ data science

Essential for the role

MS in computer science, bioinformatics or relevant computational field and 1+ year of experience OR BS and 3 years of experience

Experience in Illumina or similar workflows, raw data processing and analysis and NGS data integration and interpretation.

Experience of successful implementation of bioinformatics tools for scientific data management and analysis of large datasets such as machine learning or other state-of-the-art approaches (e.g. from next generation sequencing applications and antibody library sequencing) and harmonising different types of data sets for analyses. 

Experience in the design, development, optimisation, and scaling of informatics applications and solutions. 

Familiarity with bioinformatics algorithms and toolkits for NGS analysis.

Programming proficiency in a Linux environment of high-performance computing.

Ability to explore novel bioinformatic approaches to process and analyze long read NGS data.

Desirable for the role

Expertise in NGS workflows.

Experienced with any of R, Python, shell scripting programming languages.

Experience with creating production quality code and software engineering techniques and practices. e.g. version control, Jira, Agile, Scrum, code reviews etc.

Familiarity with multiple R&D data types, especially as they relate to therapeutic area research.

Capability of managing multiple simultaneous projects. 

Why AstraZeneca?

We follow all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

Whenweputunexpected teams in the same room, weunleashboldthinkingwith the power to inspirelife-changingmedicines. In-person working gives us the platformweneed to connect, work at pace and challenge perceptions. That’swhywework, on average, a minimum ofthreedays per week from the office. Butthatdoesn'tmeanwe’re not flexible. Webalance the expectationofbeing in the officewhilerespectingindividualflexibility. Joinus in ourunique and ambitiousworld.

Competitive salary & benefits

Close date: 10/05/2024

So, what’s next

Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you. Don't delay, apply today

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn:

Inclusion & Diversity:

Career Site:

Date Posted

19-Apr-2024

Closing Date

09-May-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

  • Senior Scientist, Immuno-Oncology

    Found in: Talent US C2 - 2 weeks ago

    Gaithersburg, United States AstraZeneca Full time

    Senior Scientist, Immuno-Oncology Gaithersburg, MD At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those...

  • Senior Scientist

    1 week ago

    Gaithersburg, United States Fladger Assoc. Inc. Full time

    Job DescriptionJob DescriptionGaithersburg, MDContract Duration: 12-36 monthsRate: NegotiableResponsibilities:Excellent employment opportunity for a Senior Scientist in the Gaithersburg, MD area.The Late-Stage Formulation Sciences Group is responsible for development of intended commercial formulations to advance the late-stage biologics portfolio, and the...

  • Senior Scientist

    1 week ago

    Gaithersburg, United States Fladger Assoc. Inc. Full time

    Job DescriptionJob DescriptionGaithersburg, MDContract Duration: 12-36 monthsRate: NegotiableResponsibilities:Excellent employment opportunity for a Senior Scientist in the Gaithersburg, MD area.Currently, we are seeking a highly motivated and broadly skilled bench Scientist with scientific and technical expertise in protein biochemistry with a track record...

  • Scientist, Antibody Expression and Purification

    Found in: Talent US C2 - 2 weeks ago

    Gaithersburg, United States AstraZeneca Full time

    Scientist, Antibody Expression and Purification We are looking for a highly motivated and talented protein biochemist with quality mindset to join our Biologics Expression Team (BET) team. The successful candidate will play a critical role in a dynamic group responsible for performing expression and purification of a wide variety of antibodies,...

  • Executive Director, Early Clinical Development Physician, Oncology

    6 days ago

    Gaithersburg, United States Taleo BE Full time

    Follow the science to pioneer new frontiers! Join the team at the heart of AstraZeneca that is committed and encouraged to follow the science. Driven by our curiosity, passion, and determination we are paving the way to change the practice of medicine in Oncology. As leaders of Clinical Development in Oncology, we push the boundaries of science to change the...

  • Scientist, Molecular Biology, Antibody Engineering

    5 days ago

    Gaithersburg, United States AstraZeneca Full time

    At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. **About AstraZeneca...

  • Scientist, in Vitro-radioconjugate

    5 days ago

    Gaithersburg, United States AstraZeneca Full time

    At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big, and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of...

  • Client Oncology Sr. RWE Data Scientist

    Found in: Talent US C2 - 2 weeks ago

    Gaithersburg, United States Sunrise Systems Full time

    Client Oncology Sr. RWE Data Scientist Job Description Do you have expertise in, and passion for Medical Affairs in Oncology? Would you like to apply your expertise to impact the Associate Director/ Sr. RWE Data Scientist role in a company that follows the science and turns ideas into life changing medicines? Then Client might be the one for you! At...

  • Director LabsQA/Audit Quality Assurance, R&D

    1 week ago

    Gaithersburg, United States CareerBuilder Full time

    Job Title: Director LabsQA/Audit Quality Assurance, R&D Quality Assurance Locations: Office based with Flexibility in Waltham MA or Gaithersburg MD What are we offering? Do you want to join a dynamic team and have influence on how Quality Assurance deliver value and assurance to AstraZeneca? Would you like to work with and influence a wide cross section of...

  • Executive Director Cell Culture and Fermentation Sciences

    Found in: Talent US C2 - 1 week ago

    Gaithersburg, United States AstraZeneca Full time

    The Executive Director, Cell Culture and Fermentation Sciences position will be responsible for all aspects of upstream development and strategic direction to support the advancement of AstraZeneca’s (AZ’s) biologics pipeline projects from pre-clinical to commercial stage. The successful candidate will also drive the development and implementation of...

  • Translational Research Scientist

    6 days ago

    Gaithersburg, United States Cartesian Therapeutics Full time

    **Summary**: **Cartesian Therapeutics is seeking a Translational Research Scientist/Senior Scientist with extensive experience in clinical biospecimen analysis to join our team and support translational research related to Cartesians early **Principal **Duties/Responsibilities**: - Analysis, quality control, and data reporting using immunoassay techniques...

  • Director LabsQA/Audit Quality Assurance, R&D

    5 days ago

    Gaithersburg, United States CareerBuilder Full time

    Job Title: Director LabsQA/Audit Quality Assurance, R&D Quality Assurance Locations: Office based with Flexibility in Gaithersburg MD or Waltham MA What are we offering? Do you want to join a dynamic team and have influence on how Quality Assurance deliver value and assurance to AstraZeneca? Would you like to work with and influence a wide cross section of...

  • Senior Scientist

    Found in: Appcast US C2 - 1 week ago

    Gaithersburg, United States Meet Full time

    Senior Scientist - Downstream Process DevelopmentLocation: Gaithersburg MarylandAbout Us:We are a leading life science recruiting agency, specializing in connecting top talent with leading pharmaceutical and biotechnology companies. Our dedicated team works closely with our clients to identify and recruit exceptional candidates who can drive innovation and...

  • Senior Scientist

    1 week ago

    Gaithersburg, United States Meet Full time

    Senior Scientist - Downstream Process DevelopmentLocation: Gaithersburg MarylandAbout Us:We are a leading life science recruiting agency, specializing in connecting top talent with leading pharmaceutical and biotechnology companies. Our dedicated team works closely with our clients to identify and recruit exceptional candidates who can drive innovation and...

  • Senior Scientist

    Found in: Appcast Linkedin GBL C2 - 2 weeks ago

    Gaithersburg, United States Meet Full time

    Senior Scientist - Downstream Process DevelopmentLocation: Gaithersburg MarylandAbout Us:We are a leading life science recruiting agency, specializing in connecting top talent with leading pharmaceutical and biotechnology companies. Our dedicated team works closely with our clients to identify and recruit exceptional candidates who can drive innovation and...

  • Senior Director of Engineering

    Found in: Appcast US C2 - 2 days ago

    Gaithersburg, United States FPC of Atlanta Full time

    Highly respected Biopharmaceutical Company seeks a Senior Director of Engineering to direct engineering and maintenance activities at this commercial scale biopharmaceutical manufacturing facility, ensuring compliance with regulations, driving continuous improvement, and managing site investments for the long term.Responsibilities:Lead engineering and...

  • Senior Director of Engineering

    1 day ago

    Gaithersburg, United States FPC of Atlanta Full time

    Highly respected Biopharmaceutical Company seeks a Senior Director of Engineering to direct engineering and maintenance activities at this commercial scale biopharmaceutical manufacturing facility, ensuring compliance with regulations, driving continuous improvement, and managing site investments for the long term. Responsibilities: Lead engineering and...

  • Senior Director of Engineering

    42 minutes ago

    Gaithersburg, United States FPC of Atlanta Full time

    Highly respected Biopharmaceutical Company seeks a Senior Director of Engineering to direct engineering and maintenance activities at this commercial scale biopharmaceutical manufacturing facility, ensuring compliance with regulations, driving continuous improvement, and managing site investments for the long term.Responsibilities:Lead engineering and...

  • Senior Director of Engineering

    Found in: Appcast Linkedin GBL C2 - 2 days ago

    Gaithersburg, United States FPC of Atlanta Full time

    Highly respected Biopharmaceutical Company seeks a Senior Director of Engineering to direct engineering and maintenance activities at this commercial scale biopharmaceutical manufacturing facility, ensuring compliance with regulations, driving continuous improvement, and managing site investments for the long term.Responsibilities:Lead engineering and...

  • Translational Research Scientist

    4 days ago

    Gaithersburg, United States Cartesian Therapeutics Full time

    Job DescriptionJob DescriptionSummaryCartesian Therapeutics is seeking a Translational Research Scientist/Senior Scientist with extensive experience in clinical biospecimen analysis to join our team and support translational research related to Cartesians early- to late-stage Clinical Trials. The Scientist will provide subject-matter expertise in a range of...