Data Analyst, Bioinformatician II RESEARCH NEUROLOGY

1 week ago

Cambridge, United States Mass General Brigham Full time
Data Analyst, Bioinformatician II RESEARCH NEUROLOGY-(3294463)

Description

A computational scientist / data manager position is available to support the Khurana Lab and Division of Movement Disorders at Brigham and Woman’s Hospital.We seek an applicant to i) perform analysis of high-throughput genomic and other omics data to enable novel discovery in Parkinson’s disease and related degenerative movement disorders in collaboration with computer scientists in the laboratories of Shamil Sunyaev and Peter Park at Harvard Medical School, and ii) manage multi-omic and clinical data collected through the Harvard Biomarker Study, a longitudinal study of Parkinson’s disease patients and healthy controls. We study the molecular basis of synucleinopathies such as, Parkinson’s, multiple systems atrophy, progressive supranuclear palsy, etc with the goal of identifying novel therapeutic targets. We develop and utilize a range of multi-omic tools to analyze and experimental models as well as human genetic and single cell datasets. The Khurana Lab operates within a highly collaborative environment where both bench biologist and computer scientists work together with clinicians, clinician-scientists and genetics counselors. In this case, the applicant will work closely with the multidisciplinary team to facilitate understanding the genetic basis of these diseases with the goal of developing precision medicines and gene-targeted therapies. Beyond genomic and omics analyses, the candidate will work with genetic study coordinators to ensure secure storage, update, and maintenance of paired genetic and clinical data from HBS 2.0 and facilitate downstream discovery. Strong computational, organizational, and communication skills are desired for this position. More senior candidates will be considered for a Research Scientist or Senior Research Scientist positions with Research Associate appointments at Brigham and Women’s Hospital and Harvard Medical School.

Job description:

Performing common/rare variant analyses including repeat and long-read sequencing analyses in collaboration with computer scientists in labs of Shamil Suyaev and Peter Park facilitating novel gene discovery.

Managing HBS study database in collaboration with MassGeneral Brigham IT services and genetic study coordinators. This includes creating a relational database in SQL, regularly updating the data tables by pulling data from third-party software platforms, backing up the data at regular intervals, performing quality control, validation and error detection on each data point, and ensuring data security and integrity. Running standard omics analysis pipelines on datasets generated in-house as well by collaborators via and experimental models. Applying and adapting existing statistical and omics tools to achieve new biological insights from unique biological datasets. Working closely with bench scientists to understand and help accomplish their research goals.

Qualifications

Qualifications:

Bachelors required. MSc or PhD in Computer Science, Mathematics in a biological science or relevant field recommended.

Skills/ Abilities/ Competencies required/desired:

·Experience with existing bioinformatics tools or pipelines to perform standard next-generation sequencing (NGS) data analysis, incl. genomic, transcriptomic, epigenomic, and others.

·Developing or adapting new algorithms and pipelines to support customized data analysis.

·Strong computational genomics experience in at least two or more of the following NGS techniques: Single-cell and bulk tissue RNA-Seq, spatial transcriptomics, small RNA-Seq, ATAC-Seq, ChIP-Seq, whole-genome sequencing (WGS), whole-exome sequencing (WES), Hi-C, etc.

·Experience in Programing with JavaScript Object Notation (JSON), R, Python that focus on computational biological applications.

·Experience in SQL database creation and management, writing stored procedures and queries for databases.

·Experience in writing programs using APIs to pull data from multiple third-party softwares

·Experience in Shell scripting

·Physical Server Administration

·Security Compliance: HIPAA

·Good organizational skills, detail oriented

Experience with common bioinformatics and genomic browsers [NCBI, Genbank, UCSC] Understanding the user of bioinformatics tools including common NGS tools [BWA, samtools, GATK] Ability to work in a highly collaborative and intellectually challenging environment.

·Ability to demonstrate professionalism

·Ability to demonstrate critical thinking and creative problem-solving abilities

·Ability to prepare manuscripts for presentation and publication

Must work independently Excellent oral and written communication skills.

  • Data Analyst, Bioinformatician II RESEARCH NEUROLOGY

    2 weeks ago

    Cambridge, United States Mass General Brigham Full time

    A computational scientist / data manager position is available to support the Khurana Lab and Division of Movement Disorders at Brigham and Woman's Hospital. We seek an applicant to i) perform analysis of high-throughput genomic and other omics data Data Analyst, Neuro, Research, Computer Scientist, Research Scientist, Analyst, Technology, Healthcare

  • Data Analyst, Bioinformatician II RESEARCH NEUROLOGY

    2 weeks ago

    Cambridge, United States Brigham & Women's Hospital(BWH) Full time

    A computational scientist / data manager position is available to support the Khurana Lab and Division of Movement Disorders at Brigham and Woman's Hospital.We seek an applicant to i) perform analysis of high-throughput genomic and other omics data to enable novel discovery in Parkinson's disease and related degenerative movement disorders in collaboration...

  • Research Analyst II

    2 weeks ago

    Cambridge, United States Harvard University Full time

    Research Analyst II will work across multiple projects with faculty at Harvard and other institutions and senior researchers at CEPR. RAIIs are expected to lead substantial portions of analytic and research projects with minimal supervision. Specific responsibilities may include assembling and preparing large data sets for analysis, conducting independent...

  • Research Analyst II

    2 weeks ago

    Cambridge, Massachusetts, United States Harvard University Full time

    Basic Qualifications Bachelor's degree in public policy, economics, statistics, computer science, education policy, social science, or a related field. At least two years of related professional work experience that includes substantial independent work with STATA and/or R programming and data analysis. Candidates must submit a resume, cover letter, and a...

  • Research Analyst, Autonomous Plant

    3 weeks ago

    Cambridge, United States LNS Research Full time

    **About LNS** Research**: It is an exciting time to become a research analyst at LNS Research. Join us on our mission to empower industry leaders to transform their organizations, and fulfill our vision of industrial companies that are agile, autonomous, and sustainable. We have successfully coached many of the world’s largest manufacturing companies on...

  • Bioinformatics Research Technician

    1 month ago

    Cambridge, United States Massachusetts General Hospital(MGH) Full time

    GENERAL SUMMARY/ OVERVIEW STATEMENT: The Kwon Laboratory at the Ragon Institute of MGH, MIT, and Harvard at the Massachusetts General Hospital in Boston (www.kwonlab.org) is seeking a highly motivated and experienced Bioinformatics Research Technician for a two-year commitment to join our team in studying the vaginal microbiome and vaginal mucosal...

  • Bioinformatics Research Technician

    4 weeks ago

    Cambridge, United States Massachusetts General Hospital(MGH) Full time

    GENERAL SUMMARY/ OVERVIEW STATEMENT: The Kwon Laboratory at the Ragon Institute of MGH, MIT, and Harvard at the Massachusetts General Hospital in Boston (www.kwonlab.org) is seeking a highly motivated and experienced Bioinformatics Research Technician for a two-year commitment to join our team in studying the vaginal microbiome and vaginal mucosal...

  • Bioinformatics Research Technician

    3 weeks ago

    Cambridge, United States Massachusetts General Hospital(MGH) Full time

    GENERAL SUMMARY/ OVERVIEW STATEMENT: The Kwon Laboratory at the Ragon Institute of MGH, MIT, and Harvard at the Massachusetts General Hospital in Boston (www.kwonlab.org) is seeking a highly motivated and experienced Bioinformatics Research Technician for a two-year commitment to join our team in studying the vaginal microbiome and vaginal mucosal...

  • Associate Scientist II, Genomics Data

    1 month ago

    Cambridge, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Associate Scientist II, Genomics Data

    4 weeks ago

    Cambridge, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Associate Scientist II, Genomics Data

    1 month ago

    Cambridge, Massachusetts, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Associate Scientist II, Genomics Data

    4 weeks ago

    Cambridge, Massachusetts, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Research Associate Ii, Immunology, in Vivo

    2 weeks ago

    Cambridge, United States BlueRock Therapeutics Full time

    **Who is BlueRock?** BlueRock Therapeutics, a wholly-owned and independently operated subsidiary of Bayer AG, is a leading engineered cell therapy company using its unique **_cell+gene_** platform to direct cellular differentiation and genetically engineer cells to create a new generation of cellular medicines that address large patient populations...

  • Associate Scientist II, Genomics Data

    4 weeks ago

    Cambridge, Massachusetts, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Associate Scientist II, Genomics Data

    1 month ago

    Cambridge, Massachusetts, United States AbbVie Full time

    Company DescriptionAbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our...

  • Software Engineer II

    4 weeks ago

    Cambridge, United States Editas Medicine Full time

    At Editas, we're driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at the...

  • Software Engineer II

    1 month ago

    Cambridge, United States Editas Medicine Full time

    Job DescriptionJob DescriptionAt Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing....

  • Software Engineer II

    1 month ago

    Cambridge, United States Editas Medicine Full time

    At Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at...

  • Software Engineer II

    4 weeks ago

    Cambridge, United States Editas Medicine Full time

    Job DescriptionJob DescriptionAt Editas, we’re driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing....

  • Software Engineer II

    1 month ago

    Cambridge, United States Editas Medicine Full time

    At Editas, we're driven by a collective purpose, to bring transformative and life changing therapies to people living with serious diseases with the greatest unmet needs. This fuels our drive to excel in scientific innovation, allowing us to harness the power and potential of CRISPR/Cas9 and CRISPR/Cpf1 (Cas12a) gene editing. We believe our people are at the...