Vice President, Technical Operations
Save this job and keep your search organized
Create a free account to save jobs, create alerts and return to this listing from your dashboard.
By continuing, you agree to our Terms & Privacy Policy.
About Vaxart:
Vaxart is a clinical-stage biotechnology company developing a range of oral recombinant vaccines based on its proprietary delivery platform. Vaxart vaccines are designed to be administered using pills that can be stored and shipped without refrigeration and eliminate the risk of needle-stick injury. Vaxart believes that its proprietary pill vaccine delivery platform is suitable to deliver recombinant vaccines, positioning the company to develop oral versions of currently marketed vaccines and to design recombinant vaccines for new indications. Vaxart’s development programs currently include pill vaccines designed to protect against coronavirus, norovirus and influenza, as well as a therapeutic vaccine for human papillomavirus (HPV), Vaxart’s first immune‑oncology indication. Vaxart has filed broad domestic and international patent applications covering its proprietary technology and creations for oral vaccination using adenovirus and TLR3 agonists.
We are looking for a Vice President, Technical Operations to join our South San Francisco team. This is an onsite position in our South San Francisco Office.
Summary:
The Vice President, Technical Operations provides strategic and hands‑on leadership for Vaxart’s engineering, qualification and validation, facilities, maintenance and calibration, external supply, and CMC project management functions. Reporting to the Chief Technology Officer, this leader builds the systems, infrastructure, external network, and integrated execution plans required to advance oral recombinant pill vaccine candidates through clinical development, regulatory approval, commercial readiness, and broad distribution. The role translates innovative science into robust, scalable, compliant, and cost‑conscious manufacturing capabilities while leading internal teams and external partners across technology transfer, supply chain, engineering, facilities, qualification, validation, and CMC project management.
Responsibilities:
- Oversee Vaxart’s facilities, utilities and equipment, including investments from concept and design through commissioning, qualification, start‑up, and sustained operation.
- Set engineering, qualification, and validation strategies for internal and external operations, using lifecycle and risk‑based approaches appropriate to each development phase.
- Develop robust, scalable, and cost‑conscious external manufacturing and supply approaches for oral recombinant pill vaccines, with emphasis on product quality, patient safety, accessibility, and reliable distribution.
- Partner with Quality to maintain compliant, phase‑appropriate systems and ensure sound, data‑driven decisions across engineering, facilities, maintenance, calibration, qualification/validation, technical transfer and supply.
- Ensure CMC compliance with applicable FDA, EMA, ICH, and other global GxP requirements, and maintain inspection readiness across Vaxart and its external network.
- Provide CMC leadership for regulatory submissions, health‑authority interactions, inspections, and responses.
- Build a high‑performing, collaborative organization that reflects Vaxart’s guiding principles of fast execution, sound decision making, passion, quality mindset, and innovation.
- Establish meaningful performance measures for engineering, supply reliability, technical readiness, cost, schedule, and partner performance; use them to drive continuous improvement and operational excellence.
- Lead technology transfers from planning through execution and regulatory approval, ensuring process knowledge, analytical readiness, control strategies, and lifecycle documentation are complete.
- Provide decisive technical leadership during investigations and troubleshooting at internal sites and external partners, using sound science and risk‑based decision making.
- Provide end‑to‑end technical oversight of CDMOs and logistics partners supporting Vaxart’s oral vaccine pipeline, including partner selection, governance, technology transfer, capacity and supply planning, performance monitoring, issue resolution, continuous improvement, and development of resilient, flexible, cost‑effective manufacturing capabilities that scale with clinical and future commercial demand.
- Ensure investments improve technical capability, manufacturing robustness, supply resilience, speed, and cost effectiveness for Vaxart’s oral vaccine platform.
- Build trusted relationships with internal partners, strategic collaborators, suppliers, and manufacturing partners to accelerate development and strengthen Vaxart’s operating network.
- Serve as a senior CMC subject‑matter expert for regulatory filings and health‑authority interactions, partnering closely with Quality, Regulatory, Clinical, Research, Finance, and Program Management
- Foster an inclusive, accountable working environment t