Associate Scientist II

Found in: Resume Library US A2 - 1 week ago


Worcester Massachusetts, United States AbbVie Full time
Job Description

Key Responsibilities

 

Responsible for working with various separation/detection platforms (PA800+, GXII-Touch, Maurice, iCE3, & UPLC/HPLC with UV, fluorescence, CAD or MS detection) & robotic liquid handlers (Protein Maker, Hamilton Star, and Tecan).

Support early & late-stage CMC development activities including cell line development (CLD), cell culture development (CCD), & purification development for product quantitation, product quality & process impurities for biologic molecules.

Develop & implement small-scale protein purification workflows by employing experience in protein purification techniques such as FPLC, IEX, SEC, HIC, etc.

Develop & implement high-throughput & automated chromatography (HPLC/UPLC, etc.), capillary electrophoresis (icIEF, CE-SDS, etc.) & spectroscopy (UV-Vis, etc.) based analytical methods for protein characterization.

Organize &  document experiments & results in electronic lab notebook (ELN) and lab informatics management system (LIMS).

Author technical memos & technical reports.

Employ experience in chromatography data software (ChemStation, Empower, etc.) and electronic notebook software (IDBS ELN, etc.).

Provide analytical support for process development, process characterization, PPQ, and GMP campaign for biologic entities.

Responsible for utilizing different separation techniques such as icIEF, SEC, CEX & Poros A.

Serve as Separation Lead for pipeline biologics programs.

Responsible for data interpretation & trending to enable data-driven decision making with other functional teams (CC,CLD, Purification, &  Pilot Lab).

Improve operational workflows & data management workflows.


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