Scientist, Biotherapeutics Production
4 weeks ago
AbbVie Biotherapeutics and Genetic Medicine is an integrated, global discovery organization responsible for biotherapeutics drug research across disease areas including immunology, oncology, virology, neuroscience, and eye care. Our scope includes the discovery of innovative biologic medicines from the early exploratory stage and their support through clinical development. We are growing a world-class team of scientists and leaders who will drive the discovery and advancement of innovative biologic-based therapies. Careers in AbbVie Biotherapeutics and Genetic Medicine provide unique opportunities to work with cross-functional teams that drive exceptional science and deliver innovative medicines to patients. We are looking for diverse candidates with strong scientific and leadership experience to join the team and can offer exciting and rewarding career opportunities for these candidates.
The Biotherapeutics Production group at AbbVie is seeking an experienced cell line and protein expression scientist to join a fast paced, high throughput, large scale mammalian expression group. The Biotherapeutics mammalian expression group supports medium to large scale (2 to 100L) expression of antibodies and therapeutic biologics in support of AbbVie’s worldwide drug discovery efforts.
Key Responsibilities:
Expression of antibodies, bi-specifics, and other novel biologics formats to support therapeutic area drug discovery projects.
Transient and stable expression vector design, generation of stable CHO cell lines.
Mammalian cell culturing, including cryopreservation.
Transient protein expression in HEK and CHO cells.
Protein expression from stable CHO pools, cell lines, and hybridomas.
Process development and optimization for batch and fed-batch Wave bioreactor and shake flask expressions of transient and stable CHO cell lines.
Purification and biophysical characterization of analytical scale expression samples, including analytical HPLC.
Work independently on the design, execution, and interpretation of experimental results.
Analyze, document, and report data concisely and rigorously.
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