Specialist, Materials

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

As the Materials & Supply Operations Specialist you will own SAP material master data, maintaining accuracy and compliance across systems, and support production through detailed scheduling, process order management, and BOM updates. Collaborate with supply operations, warehouse and manufacturing teams to resolve issues, ensure seamless material flow, maintain SOP documentation, and drive continuous improvement in data integrity and system efficiency.

Key Accountabilities/ Core Job Responsibilities:

• Serve as steward of SAP material master data, ensuring accuracy and compliance across systems.
• Maintain detailed production schedules in SAP to align with manufacturing and supply plans.
• Create, release, and monitor SAP process orders to support timely and efficient production.
• Manage and update Bills of Materials (BOMs) and manufacturing master data in SAP to reflect current recipes and approved processes.
• Support procurement activities by maintaining procurement master data, coordinating material requirements and ensuring timely ordering.
• Partner with materials management and manufacturing teams to resolve material- or order-related issues.
• Monitor and troubleshoot SAP transactions to maintain seamless material flow.
• Maintain documentation (SOPs, work instructions) for SAP and materials operations processes.
• Contribute to continuous improvement initiatives that enhance data integrity, process efficiency, and system utilization.

Qualifications/Skills:

• Bachelor's degree in Supply Chain Management, Business, Life Sciences, Engineering, or a related field OR an associate's degree with equivalent work experience
• Minimum of 2 years of post-college professional experience in supply chain, materials management, or manufacturing operations.
• Experience with SAP (or comparable ERP system) is required;
• Experience in a manufacturing environment preferred
• Strong understanding of material master data, process/production orders, and BOM management within ERP systems.
• Familiarity with procurement processes and production planning concepts.
• Excellent attention to detail and organizational skills, with the ability to manage multiple priorities.
• Strong problem-solving, analytical, and communication skills.
• Ability to collaborate effectively across functions.
• Proficiency in Microsoft Excel and other standard business tools

Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.