Senior/Principal Scientist, Anti-Drug Conjugate

About Us

Crescent Biopharma's vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company's pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies either as single agents or as part of combination regimens to treat a range of solid tumors. For more information, visit and follow the Company on LinkedIn and X.

Position Overview

Crescent Biopharma is seeking an experienced Senior/Principal Scientist, Antibody-Drug Conjugate (ADC)Research & Development. This individual will provide strategic and technical oversight for all aspects of Crescent's novel drug discovery efforts from lead identification to preclinical development and commercialization. The ideal candidate is a creative and innovative scientist with deep scientific/technical expertise and hands on experience leading the successful discovery and development of drug candidates across many biologics modalities, such as monoclonal antibodies, antibody drug conjugates, and peptides in the field of oncology.

• Contribute the strategic approach for target selection, antibody discovery and therapeutic approach to identify and develop novel targeted therapeutics.
• Provide scientific guidance and mentorship to a growing research team.
• Lead technological innovations to drive continual improvements and optimization of Crescent's antibody and ADC programs enabling continued success as the organization grows.
• Effectively manage work conducted at CROs and external partners.
• Represent the company at scientific conferences and author high impact peer reviewed publications.
• Deliver research and development reports to support regulatory submissions (IND/IMPD, information requests, amendments, briefing books, BLA/MAA etc.).

• Ph.D. in Life Science with at least 5 years of combined R&D experience from the biotech/biopharmaceutical industry and world-class academic institutions with demonstrated career growth and experience gained in growing R&D organizations. M.S. with equivalent experience will also be considered.
• Deep experience in drug discovery and development in oncology.
• Successful leadership of antibody and ADC program(s) from discovery to preclinical development and commercialization.
• Background in cancer research, immunology and/or cell biology field(s).
• Intellectually and scientifically curious, and a collaborative member of multi-functional project teams.
• Extremely scientifically rigorous and creative and ability to create an environment where imaginative and constructive dialog can flourish, conflict is well-managed and complex issues are driven to full resolution.
• Hands on experience with regulatory requirements for the development and approval of novel therapeutics in oncology.

• Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment.
• Competitive compensation, including base salary, performance bonus, and equity.
• 100% employer-paid benefits package.
• Flexible PTO.
• Two, one-week company-wide shutdowns each year.
• A commitment to your professional development, with access to resources, mentorship, and growth opportunities. 

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Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.