Principal Bioinformatics Scientist

SHIFT:

Day (United States of America)

Seeking Breakthrough Makers

Children's Hospital of Philadelphia (CHOP) offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.

At CHOP, your experience is valued; your voice is heard; and your contributions make a difference for patients and families. Join us as we build on our promise to advance pediatric care—and your career.

CHOP does not discriminate on the basis of race, color, sex, national origin, religion, or any other legally protected categories in any employment, training, or vendor decisions or programs. CHOP recognizes the critical importance of a workforce rich in varied backgrounds and experiences and engages in ongoing efforts to achieve that through equally varied and non-discriminatory means.

A Brief Overview

The Principal Bioinformatics Scientist position is an advanced level position for a PhD level professional and serves as the final stage of the bioinformatics staff individual contributor. Further advancement in this area is either within the academic faculty ladder or bioinformatics management. The focus of the position is a completely enabled subject matter expert who performs both independent, high-functioning collaboration with biomedical investigators and independent bioinformatics methods research. The position allows for a wide variety of activities described within the job responsibilities and encompasses positions within both research and clinical environments. Activities occur with minimal supervision and expectation for highly independent judgment, development of bioinformatics workflows and processes, and presentation of results. The Principal Bioinformatics Scientist will define best practices in collaborative science as a bioinformatics domain scientific collaborator. Academic output is a focus of this position and is expected with no formal supervision. The Principal Bioinformatics Scientist is considered a preeminent scientist within the group and a leader in the bioinformatics discipline as commonly recognized by all stakeholders (collaborators, peers, management). The individual mentors other team members regularly. This individual is capable of leading complex bioinformatics projects critical to the organization based on both technical, academic, and social prowess.

The Principal Bioinformatics Scientist must be able to perform all responsibilities listed in the Bioinformatics Scientist III job description. All responsibilities listed in this description are additional.

What you will do

• Pre-Analysis (5%): Lead development of application portfolio by developing knowledge of internally developed systems, open-source programs, and commercial applications. Provide efficient data management support.
• Understand and help define strategic evolution of shared data processing resources relative to industry
• Help define boundaries and limitations of shared resources such as complex data manipulation pipelines, etc.
• Help to define governance of shared resources
• Advocate for advanced solutions and effective management of shared resources
• Coding (5%): Code and generally support code and applications on behalf of collaborative project and/or team.
• Help define strategy, governance, and policy for code sharing, language standards, QC, and code reviews
• Data Analysis (20%): Analyze data of high complexity by applying sound statistical and commonly accepted bioinformatics methods to -omics data with limited direction from collaborative team
• Lead multiple specialty analytical and/or biomedical areas that serve one or more collaborative teams
• Regularly promote analytical best practices in specialty analytical areas for adoption throughout the organization
• Collaboration (40%): Lead bioinformatics portion of scientific collaborations as the primary bioinformatics resource
• Serve as equivalent scientific voice/role to principal investigator
• As bioinformatics point, assume lead management role for projects of high complexity, including all aspects of timelines, risk identification and mitigation strategies, and communication mechanisms
• Lead project-based satisfaction and performance activities in order to achieve aims
• Lead continual objective, hard discussions about overall health of project and relationship
• Regularly develop new collaborations as a result of subject matter expert role throughout organization
• Academic Output (30%): Lead project-based presentations, grants, and manuscripts, with subsequent review by peers and mentors
• Lead or senior authorship on regular bioinformatics-focused manuscripts and publications
• Lead or senior authorship on regular podium presentations and posters
• Lead authorship on entire grant and award proposals

Education Qualifications

• Doctorate - Required
• Doctorate biological or computational discipline - Preferred

Experience Qualifications

• At least ten (10) years experience in applied bioinformatics, genomics, and computational work - Required

Skills and Abilities

• Ability to independently conceive of, plan, implement, validate, and disseminate entire research projects is required.
• Understanding or the molecular etiopathology of common diseases and syndromes is required.
• Ability to assume principal investigator or similar role in academic research is required.
• Strong UNIX/LINUX expertise required.
• Proficiency in R or similar commonly used bioinformatics language required
• Experience with Python, Perl, or other languages required.
• Experience with pipeline or workflow development frameworks required.
• Experience with management and analysis of complex data types required.
• Proficiency in various open source and commercial bioinformatics resources and software required.
• Experience with genomic/proteomic data analysis methods required.
• Experience or knowledge of technologies commonly used in biological labs, such as PCR, cloning, electrophoresis gels, and cell culture required.
• Knowledge of the working mechanism of microarray, NGS, mass spectrometry, or other high-throughput technologies and awareness of their strengths and weaknesses, as well as applicability to a specific biological problem is required.
• Familiarity with resources of genomic data sets and analysis tools, such as UCSC Genome Browser, Bioconductor, ENCODE, and NCBI databases is required.
• Ability to correctly select and perform statistical tests for most types of genomic data, and to properly interpret their results in the scenario of a specific study is required.
• Ability to leverage unique knowledge of bioinformatics, applied biostatistics, molecular biology, and measurement platforms for effective scientific discussion with biologists and clinicians is required.
• Ability to determine most favorable academic output as a primary research outcome is required.
• Ability to objectively critique results and present as valid or questionable, taking into account all aspects of study design, technical issues, and limitations of workflows is required.
• Ability to objectively assess significance of results relative to larger academic and commercial domain is required.
• Ability to identify, troubleshoot data or result abnormalities by reviewing all major aspects of a study is required.
• Accountability and attention to timelines.
• Excellent organization and communication skills with an emphasis on strong presentation skills
• Ability to independently plan and execute analyses of the highest complexity required
• Ability to provide objective validation of results required
• Ability to work in a team environment.

To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, CHOP employees who work in patient care buildings or who have patient facing responsibilities must receive an annual influenza vaccine. Learn more.

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SALARY RANGE:

$115, $152,450.00 Annually

Salary ranges are shown for full-time jobs. If you're working part-time, your pay will be adjusted accordingly.

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At CHOP, we are committed to fair and transparent pay practices. Factors such as skills and experience could result in an offer above the salary range noted in this job posting. Click here for more information regarding CHOP's Compensation and Benefits.