Senior Scientist

Career CategoryScientificJob DescriptionJoin Amgen's Mission of Serving Patients

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist - PKDM (NAMs-Based Translational ADME Sciences)What you will do

Let's do this. Let's change the world. Amgen's Pharmacokinetics and Drug Metabolism (PKDM) organization is seeking an innovative Senior Scientist with deep expertise in advanced cell-based in vitro systems to lead the next generation of ADME science through the adoption of New Approach Methodologies (NAMs). In this vital role you will focus on the design, qualification, and implementation of 3D organoid and microphysiological system (MPS, "organ-on-chip") platforms to improve translational prediction of drug disposition, target engagement, and pharmacodynamic response.

You will play a pivotal role in establishing NAMs-based strategies to:

• Bridge preclinical and clinical pharmacokinetic understanding
• Uncover mechanisms of biotransformation (including payload release for ADCs), and clearance
• Ultimately inform candidate prioritization, dosing strategies, and translational risk assessment across therapeutic modalities.

PKDM spans early discovery through IND and NDA stages, working in close partnership with Discovery, Biology, Toxicology, and Clinical Pharmacology to establish dose–exposure–response relationships and pharmacodynamic biomarker endpoints that guide safe and effective human dosing.

Key Responsibilities

• Lead the development and qualification of high-fidelity, human-relevant in vitro models, including 3D cultures and microphysiological systems, to assess drug disposition, biotransformation, and pharmacodynamic effects.
• Design and execute experimental strategies that integrate quantitative endpoints, enabling correlation of exposure and response across NAMs and traditional models.
• Advance throughput and data scalability by implementing assay miniaturization, plate-based automation, and high-content imaging workflows.
• Apply deep cell biology expertise to refine parenchymal–stromal co-culture systems and incorporate complementary analytical endpoints to define cellular phenotype and pharmacodynamic response.
• Characterize responses using flow cytometry, multiplexed analytical sampling, confocal microscopy, and live-cell imaging (e.g., Incucyte).
• Adopt computational tools and quantitative data pipelines to streamline analysis of complex kinetic and imaging datasets.
• Collaborate across disciplines to define mechanism-based PK liabilities, support dose selection hypotheses, and guide preclinical-to-clinical translation.
• Communicate findings clearly and effectively to inform cross-functional teams and drive data-driven decision-making in a fast-paced R&D environment.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a [type of person] with these qualifications.

Basic Qualifications:

Doctorate degree in Biomedical Engineering, Pharmacology, Systems Biology, Cellular & Molecular Biology, Biophysics, or a related discipline [and relevant post-doc where applicable]

Or

Master's degree and 3 years of relevant industry experience

Or

Bachelor's degree and 5 years of relevant industry experience

Preferred Qualifications:

• 2+ years of postdoctoral or industry experience applying 3D cellular or microphysiological systems to study drug disposition or disease biology.
• Demonstrated experience in cell model and/or MPS device fabrication, culture, and integration with analytical readouts.
• Working understanding of pharmacokinetic principles for small and large molecules and of preclinical ADME processes (absorption, distribution, metabolism, and excretion).
• Familiarity with bioanalytical and imaging techniques supporting quantitative in vitro pharmacology.
• Strong communication, data interpretation, and collaboration skills; ability to synthesize complex data into actionable insights for multidisciplinary project teams.
• Demonstrated ability to innovate, adapt, and deliver in a dynamic research environment.

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models, including remote and hybrid work arrangements, where possible

Apply now and make a lasting impact with the Amgen team.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Salary Range

139,001.00 USD - 175,417.00 USD

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