Scientist/Sr. Scientist/Principal Scientist

6 days ago

Exton, Pennsylvania, United States Frontage Laboratories Full time

Senior/Principal Scientist – Process Chemistry

Senior/Principal Scientist – Process Chemistry

Discovery Chemistry & API GMP Kilo-Lab

Location: Exton, PA

Frontage Laboratories Inc. is an award winning, publicly listed (HKSE), full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China, and growing over 30% YOY. Our core competencies include drug metabolism, pharmacokinetics/ pharmacodynamics (PK/PD), safety and toxicology, bioanalytical services, chemistry and manufacturing controls for drug development, and core laboratory services for clinical trials.

Position Summary:

Frontage Laboratories is expanding its API GMP capabilities to support early- and mid-phase development programs for global biotech, pharmaceutical, and academic partners.

We are seeking an experienced Process Chemistry Scientist to lead route scouting, process optimization, scale-up, and GMP batch support for small-molecule APIs. This is a hands-on laboratory role with technical leadership responsibilities and potential advancement to Associate Director, depending on experience.

Key Responsibilities:

  • Process Development & Scale-Up

    • Design, develop, and optimize scalable synthetic routes for small-molecule APIs and intermediates.
  • Conduct reaction optimization, impurity profiling, and robustness studies.

  • Execute demonstration/engineering batches and support kilogram-scale manufacturing campaigns.

  • GMP Kilo-Lab Technical Support

    • Contribute to batch record drafting, process descriptions, and execute support kilogram-scale manufacturing campaigns.
  • Provide on-the-floor technical support during non-GMP and GMP campaigns.
  • Troubleshoot process deviations and equipment issues in real time.

  • Collaborate with QA, QC, CMC Operations, EHS, and Engineering.

  • Client Interaction & Project Leadership

    • Serve as the technical point-of-contact for client programs.
  • Present data clearly, propose development strategies, and manage timelines.

  • Support CMC planning, risk mitigation, and tech-transfer discussions.

  • Documentation & Regulatory

    • Prepare process development reports, tech-transfer packages, and supporting CMC documentation.

  • Ensure full compliance with non-GMP & GMP requirements and contribute to IND process sections.

  • Team & Capability Development

    • Mentor junior chemists and contribute to building best practices in the new kilo-lab.
  • Support implementation of SOPs, equipment capabilities, and continuous improvement initiatives.
  • Participate in hiring and onboarding as the group expands.

Qualifications (Flexible for Senior Scientist Associate Director)

  • Advanced degree (MS or PhD) in Organic Chemistry, or related field, with significant industry experience in process chemistry, CRO/CDMO, or pharmaceutical development.
  • Strong hands-on expertise in multi-step organic synthesis, route design, process optimization, impurity control, and scale-up.
  • Working understanding of kilo-lab or pilot-plant operations and GMP manufacturing support.
  • Experience with analytical data interpretation and process safety considerations.
  • Demonstrated ability to effectively communicate with cross-functional teams and external clients.
  • Proven leadership ability — ranging from mentoring peers (Senior Scientist) to providing strategic program direction (Principal Scientist / Associate Director).
  • Ability to thrive in a fast-paced CRO environment with multiple concurrent client programs.

Salary and Benefits:

Frontage Laboratories offers a competitive compensation and benefits package including health and dental insurance, a 401(k) plan, disability insurance, and life insurance

Frontage Laboratories Inc. is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, among other things, or status as a qualified individual with disability.

  • Quality Control Analytical Scientist

    1 week ago

    Exton, Pennsylvania, United States Piper Companies Full time

    Piper Companiesis seeking aQuality Control Analytical Scientist (ELISA) tojoin a rapidly growing biopharmaceutical organization advancing gene therapies for rare genetic disorders. This onsite position inExton, PAoffers hands-on involvement with ELISA and complementary analytical assays supporting GMP Quality Control operations.Responsibilities of the...

  • Quality Control Analytical Scientist

    2 weeks ago

    Exton, Pennsylvania, United States Piper Companies Full time

    Piper Companiesis seeking aQuality Control Analytical Scientist (Flow Cytometry) to support GMP analytical testing for a late-stage biopharmaceutical organization advancing gene therapies for rare genetic disorders. This onsite role inExton, PAoffers hands-on experience with flow cytometry and related cell-based assays supporting clinical...

  • Associate Scientist, Bioanalytical Services

    1 week ago

    Exton, Pennsylvania, United States Frontage Laboratories Full time

    Associate Scientist, Bioanalytical ServicesTitle: Associate Scientist, Bioanalytical ServicesLocation: Exton, PA (Corporate)Responsibilities:Associate Scientist / Bioanalytical Services Essential Functions Provide support for running sensitive, reliable and efficient LC-MS/MS bioanalytical assays for TK/PK assessmentCoordinate study activities with...

  • Scientist II, Analytical Outsource

    2 weeks ago

    Exton, Pennsylvania, United States Eisai Full time

    At Eisai, satisfying unmet medical needs and increasing the benefits healthcare provides to patients, their families, and caregivers is Eisai's human health care (hhc) mission. We're a growing pharmaceutical company that is breaking through in neurology and oncology, with a strong emphasis on research and development. Our history includes the development of...

  • Water & Wastewater Engineer

    4 days ago

    Exton, Pennsylvania, United States Kleinfelder Full time

    Step into Your New RoleAs aWater/Wastewater Engineer,you will work closely with principal technical professionals and project managers to engaged in and deliver the total lifecycle of our clients' needs. That may include asset management and planning, assistance with project funding applications, preliminary and final designs, procurement and bid phase...

  • Senior AI Engineer

    4 days ago

    Exton, Pennsylvania, United States AXA XL Full time

    AXA XL is an Equal Opportunity Employer.Senior AI EngineerNew York, NY | Hartford, CT | Stamford, CT | Morristown, NJ | Exton, PAAXA XL recognizes digital, data and information assets are critical for the business, both in terms of managing risk and enabling new business opportunities. Data Science and AI assets should not only be high quality but also drive...

  • Scientist/Associate Scientist- Biomarker

    4 days ago

    Exton, United States Frontage Laboratories Full time

    Scientist/Associate Scientist- BiomarkerTitle: Scientist/Associate Scientist, BiomarkerLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada and China. Our core competencies include drug metabolism, pharmacokinetics/...

  • Scientist/Associate Scientist- Biomarker

    2 weeks ago

    Exton, United States Frontage Laboratories Full time

    Job DescriptionJob DescriptionScientist/Associate Scientist- BiomarkerA variety of soft skills and experience may be required for the following role Please ensure you check the overview below carefully.Title: Scientist/Associate Scientist, BiomarkerLocation: Exton, PAFull-timeFrontage Laboratories Inc. is an award winning, full-service, CRO/Contract Research...

  • Associate Scientist

    12 hours ago

    Exton, United States Frontage Laboratories Full time

    Job Title: Associate Scientist, Drug Metabolism and Pharmacokinetics (DMPK) Location: Exton, PA Reports To: Vivarium Manager / Study DirectorCompany Frontage Laboratories Inc. is an award winning, publicly listed, full-service CRO/Contract Research Organization operating over 25 state-of-the-art laboratories across the US, Canada, and China, growing...

  • Quality Control Analytical Scientist

    19 hours ago

    Exton, United States Piper Companies Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (qPCR) to join a growing biopharmaceutical organization pioneering gene therapies for rare genetic disorders. This onsite position in Exton, PA provides the opportunity to perform advanced molecular testing and DNA-based assays that directly support GMP manufacturing and product quality...

  • Quality Control Analytical Scientist

    2 days ago

    Exton, United States Piper Companies Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (qPCR) to join a growing biopharmaceutical organization pioneering gene therapies for rare genetic disorders. This onsite position in Exton, PA provides the opportunity to perform advanced molecular testing and DNA-based assays that directly support GMP manufacturing and product quality...

  • Quality Control Analytical Scientist

    5 days ago

    Exton, United States Piper Companies Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (qPCR) to join a growing biopharmaceutical organization pioneering gene therapies for rare genetic disorders. This onsite position in Exton, PA provides the opportunity to perform advanced molecular testing and DNA-based assays that directly support GMP manufacturing and product quality...

  • Quality Control Analytical Scientist

    2 weeks ago

    Exton, United States Piper Companies Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (Flow Cytometry) to support GMP analytical testing for a late-stage biopharmaceutical organization advancing gene therapies for rare genetic disorders. This onsite role in Exton, PA offers hands-on experience with flow cytometry and related cell-based assays supporting clinical...

  • Quality Control Analytical Scientist

    2 days ago

    Exton, United States Piper Companies Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (Flow Cytometry) to support GMP analytical testing for a late-stage biopharmaceutical organization advancing gene therapies for rare genetic disorders. This onsite role in Exton, PA offers hands‑on experience with flow cytometry and related cell‑based assays supporting clinical...

  • Quality Control Analytical Scientist

    5 days ago

    Exton, United States Piper Companies Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (Flow Cytometry) to support GMP analytical testing for a late-stage biopharmaceutical organization advancing gene therapies for rare genetic disorders. This onsite role in Exton, PA offers hands‑on experience with flow cytometry and related cell‑based assays supporting clinical...

  • Quality Control Analytical Scientist

    21 hours ago

    Exton, United States Zachary Piper Solutions Full time

    Piper Companies is seeking a Quality Control Analytical Scientist (Flow Cytometry) to support GMP analytical testing for a late-stage biopharmaceutical organization advancing gene therapies for rare genetic disorders. This onsite role in Exton, PA offers hands-on experience with flow cytometry and related cell-based assays supporting clinical...