Lead Software Engineer, Internal Systems

Are you ready to join Connecticut Innovation's vibrant community of innovators? Connecticut Innovations ("CI") is Connecticut's strategic venture capital arm, and we are passionate about serving our portfolio of 220+ companies across various industries, with strengths in life sciences, technology, and climate tech.

Come join Bexorg, Decode the Brain. Reinvent Drug Discovery

Recent funding news: Bexorg Raises $42.5M to Transform CNS Drug Development with World's First Integrated AI and Whole-Human Brain Platform

About Bexorg

Bexorg develops systems that plan and execute human brain perfusion experiments and manage a growing biobank (10,000+ samples and growing rapidly) with zero tolerance for data failures.

Since Bexorg was founded by Dr. Zvonimir Vrselja and Dr. Nenad Sestan at Yale University in 2021, the company has rapidly advanced its whole-human brain drug discovery platform.

The company's foundational research, which demonstrated that cellular and metabolic activity could be restored to postmortem brains hours after death, was published in Nature (Nature
568
, 336– In 2024, Bexorg partnered with the University of Oxford and the UK Medical Research Council as part of a collaborative effort to advance translational gene therapy development for neurological diseases. In mid-2025, the company announced a research collaboration with pharmaceutical company Biohaven Ltd. to advance two of Biohaven's preclinical development programs. In the last 18 months, Bexorg has expanded its proprietary dataset to include hundreds of whole-brain experiments spanning Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions, establishing one of the world's largest repositories of human CNS data.

Building on continuous growth of its proprietary human brain dataset, Bexorg is now training foundation models on petabyte-scale human brain molecular data, creating the first AI system grounded in experimentally measured human neurobiology.

Role Summary

We are seeking a Lead Full Stack Architect to spearhead the architecture, development, and

continuous improvement of our internal data applications and platform services. In this senior

role you will design end‑to‑end web solutions that integrate proprietary data pipelines, AI

services, and visualization layers, driving our mission to revolutionize treatments for neurological

disorders.

Own the next generation of our data application. You will lead green‑field, full‑stack efforts to build a secure,
cloud‑native web app that lets scientists schedule brain perfusion runs
, capture petabyte‑scale data in real time, and explore insights through rich interactive dashboards. You will chart the technical vision, select the stack, and guide implementation from proof‑of‑concept to production.

Key Responsibilities:

Product & Architecture Leadership –
Define the technical vision and system design

for internal data applications; translate business requirements into scalable, maintainable

architectures.

Full‑Stack Development –
Build and maintain front‑end (e.g., React/TypeScript) and

back‑end services (Python/FastAPI, , or Go) that integrate seamlessly with

Google Cloud services and proprietary code.

Data & API Integration –
Collaborate with data engineering to expose curated datasets

via REST/GraphQL APIs; design efficient data‑access layers and caching strategies for

high‑throughput analytics.

Cloud Infrastructure & DevOps –
Own CI/CD, container orchestration

(GKE/Cloud Run), infrastructure‑as‑code (Terraform), observability, and cost

management.

Security & Compliance –
Implement authentication/authorization, encryption in

transit/at rest, and least‑privilege IAM; partner with IT to meet HIPAA and SOC 2 goals.

Performance & Reliability Engineering –
Optimize latency and throughput; design for

fault tolerance, auto‑scaling, and zero‑downtime deploys.

Team Mentorship –
Provide technical leadership and mentorship to full‑stack and

data‑engineering teammates; establish coding standards and best practices.

Cross‑Functional Collaboration –
Work closely with neuroscientists, product owners,

AI/ML engineers, and cloud architects to deliver features that unlock scientific insight.

Qualifications

• 7 + years building production‑grade full‑stack applications; 3 + years in an architect or principal engineer role.
• Expertise with modern JavaScript/TypeScript frameworks (React, , or similar) and backend development in Python, , Go, or Java.
• Deep understanding of cloud‑native architectures on Google Cloud Platform (Cloud Functions, Cloud Run, Pub/Sub, BigQuery, Cloud Storage) and experience designing secure VPC networks.
• Proven track record deploying microservices with Docker & Kubernetes; hands‑on with CI/CD tools (GitHub Actions, Cloud Build) and infrastructure‑as‑code (Terraform, Pulumi, or Deployment Manager).
• Strong database design skills across relational (PostgreSQL) and analytical stores (BigQuery); familiarity with NoSQL (Firestore, MongoDB) and graph stores is a plus.
• Experience integrating real‑time or batch data pipelines (Dataflow / Apache Beam, Kafka) into web applications.
• Solid grounding in web security, OAuth/OIDC, and role‑based access control.
• Excellent communication and stakeholder‑management skills; ability to translate complex technical concepts for non‑technical audiences.
• Passion for Bexorg's mission and enthusiasm for working at the intersection of neuroscience, big data, and AI.

Preferences

• Exposure to biology, genomics, or scientific imaging data.
• Experience embedding data‑visualization libraries (Plotly, ) in production apps.
• Familiarity with ML Ops, feature stores, and serving AI models at scale

EQUAL OPPORTUNITY EMPLOYER

Connecticut Innovations and its portfolio companies are an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We have strict wage minimums, generous benefits, and personal leave policies. Our goal is to provide safe, rewarding, and empowering work environments for all who interact with our company and/or portfolio companies.